Noninvasive photoacoustic measurement of the composite indicator dilution curve for cardiac output estimation.

Recently, the measurement of indicator dilution curves using a photoacoustic (PA) technology was reported, which showed promising results on the noninvasive estimation of cardiac output (CO) that is an important hemodynamic parameter useful in various clinical situations. However, in clinical practice, measuring PA indicator dilution curves from an arterial blood vessel requires an ultrasound transducer array capable of focusing on the targeted artery. This causes several challenges on the clinical translation of the PA indicator dilution method, such as high sensor cost and complexity. In this paper, we theoretically derived that a composite PA indicator dilution curve simultaneously measured from both arterial and venous blood vessels can be used to estimate CO correctly. The ex-vivo and in-vivo experimental results with a flat ultrasound transducer verified the developed theory. We believe this new concept would overcome the main challenges on the clinical translation of the noninvasive PA indicator dilution technology.

[1]  F. Grodins,et al.  Basic Concepts in the Determination of vascular Volumes by Indicator‐Dilution Methods , 1962, Circulation research.

[2]  J. Menke.  Carotid MR angiography with traditional bolus timing: clinical observations and Fourier-based modelling of contrast kinetics , 2009, European Radiology.

[3]  I. Y. Petrov,et al.  Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood , 2011, Biomedical optics express.

[4]  E. Rubinstein,et al.  Transcutaneous Fluorescence Dilution Cardiac Output and Circulating Blood Volume during Hemorrhagic Hypovolemia , 2005, Anesthesiology.

[5]  H. V. van Beusekom,et al.  Intravascular photoacoustic imaging of human coronary atherosclerosis. , 2011, Optics letters.

[6]  T. Edrich,et al.  Cardiac Output Monitoring Using Indicator-Dilution Techniques: Basics, Limits, and Perspectives , 2010, Anesthesia and analgesia.

[7]  K. Zierler,et al.  On the theory of the indicator-dilution method for measurement of blood flow and volume. , 1954, Journal of applied physiology.

[8]  P. Marik,et al.  Noninvasive cardiac output monitors: a state-of the-art review. , 2013, Journal of cardiothoracic and vascular anesthesia.

[9]  B. Reichart,et al.  Continuous cardiac output by femoral arterial thermodilution calibrated pulse contour analysis: comparison with pulmonary arterial thermodilution. , 1999, Critical care medicine.

[10]  Avishay Eyal,et al.  Photoacoustic thermal diffusion flowmetry , 2012, Biomedical optics express.

[11]  Andreas Mandelis,et al.  Frequency-domain photoacoustic phased array probe for biomedical imaging applications. , 2011, Optics letters.

[12]  Da Xing,et al.  In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy. , 2012, Optics letters.

[13]  Kanu Chatterjee,et al.  The Swan-Ganz Catheters: Past, Present, and Future: A Viewpoint , 2009, Circulation.

[14]  J. Hopman,et al.  Cardiac Output Measurement Using a Modified Carbon Dioxide Fick Method: A Validation Study in Ventilated Lambs , 2007, Pediatric Research.

[15]  M. Cecconi,et al.  A Systematic Review and Meta-Analysis on the Use of Preemptive Hemodynamic Intervention to Improve Postoperative Outcomes in Moderate and High-Risk Surgical Patients , 2011, Anesthesia and analgesia.

[16]  D. Higgins,et al.  Haemodynamic monitoring with pulse-induced contour cardiac output (PiCCO) in critical care. , 2003, Intensive & critical care nursing.

[17]  Kenichi Sato,et al.  Angiographic Circulation Time and Cerebral Blood Flow during Balloon Test Occlusion of the Internal Carotid Artery , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  Youzhi Li,et al.  Measurement of cardiac output by use of noninvasively measured transient hemodilution curves with photoacoustic technology. , 2014, Biomedical optics express.

[19]  Paul C Beard,et al.  Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imaging. , 2006, Optics letters.