Induced pluripotent stem cells (iPS) derived disease models: In vivo to in vitro gaps

Induced pluripotent stem (iPS) cells are one of the most soughtafter tools of regenerative medicine created by extra-physiological endeavours of reprogramming which help not only as promising avenues for therapy but also for recapitulating the disease pathology in a dish and also as modelling systems for studying organ/tissue behaviours. iPS cell based clinical trials having been started for treating age -related macular degeneration and recently for Parkinson’s though seem promising, several hurdles such as genetic mutations in the cells and adverse effects remain obstacles to further progress.