Exacerbation of Metastatic Disease Shortly after Administration of Tamoxifen in ER Negative Advanced Breast Carcinoma. A Case Report

In a patient with long untreated slow-growing osteoblastic bone metastases from an ER/PgR negative breast carcinoma, new metastatic sites in many lymphnodes pleura and massively in liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug and this unusually rapid spreading of the disease may be considered only as a hypothesis, as it is based wholly on clinical outcome. However, reporting of any exacerbation of breast cancer apparently induced by tamoxifen, even if only anecdotal, is advisable.

[1]  S. Carter.  Predictors of response and their clinical evaluation , 1981, Cancer Chemotherapy and Pharmacology.

[2]  M. Baum.  The role of endocrine therapy in primary breast cancer. , 1990, Journal of steroid biochemistry.

[3]  G. Cocconi,et al.  Neoadjuvant Chemotherapy or Chemotherapy and Endocrine Therapy in Locally Advanced Breast Carcinoma: A Prospective, Randomized Study , 1990, American journal of clinical oncology.

[4]  P. Vassilakos,et al.  Evaluation of estrogen receptors by immunocytochemistry on fine‐needle aspiration biopsy specimens from breast tumors , 1987, Cancer.

[5]  J. Wong,et al.  Response of advanced breast cancer to total endocrine ablation after exacerbation on tamoxifen: Results in seven patients and possible mechanism of action , 1987, Journal of surgical oncology.

[6]  G. Cocconi,et al.  Determination of Estrogen Receptors in Human Breast Cancer: Comparison between Enzyme Immunoassay and Dextran-Coated Charcoal Method , 1986, Tumori.

[7]  L. Cone,et al.  Tumor lysis syndrome after tamoxifen flare. , 1986, The New England journal of medicine.

[8]  E. Gelmann,et al.  Autocrine and paracrine growth regulation of human breast cancer. , 1986 .

[9]  R. Gray,et al.  Postoperative chemotherapy and chemohormonal therapy in women with node-positive breast cancer. , 1986, NCI monographs : a publication of the National Cancer Institute.

[10]  R. Gelber,et al.  Adjuvant treatment for early breast cancer: the Ludwig breast cancer studies. , 1986, NCI monographs : a publication of the National Cancer Institute.

[11]  H. Mouridsen,et al.  Adjuvant tamoxifen in postmenopausal high-risk breast cancer patients: present status of Danish Breast Cancer Cooperative Group trials. , 1986, NCI monographs : a publication of the National Cancer Institute.

[12]  A. Nicolin,et al.  Chemotherapy following estrogen-induced expansion of the growth fraction of human breast cancer. , 1985, Cancer research.

[13]  M. Daidone,et al.  Cell kinetics as a prognostic marker in node‐negative breast cancer , 1985, Cancer.

[14]  G. Sherbet,et al.  EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER , 1985, The Lancet.

[15]  M. Lippman,et al.  Tamoxifen flare in advanced endometrial carcinoma. , 1985, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  C. Osborne,et al.  Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. , 1985, Cancer research.

[17]  R. Sutherland,et al.  Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare. , 1984, European journal of cancer & clinical oncology.

[18]  R. Mehta,et al.  Distribution of antiestrogen-specific binding sites in normal and neoplastic mammary gland. , 1984, Oncology.

[19]  C. Redmond,et al.  Influence of tumor estrogen and progesterone receptor levels on the response to tamoxifen and chemotherapy in primary breast cancer. , 1983, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  I. Nenci.  Estrogen receptor cytochemistry in human breast cancer: Status and prospects , 1981, Cancer.

[21]  W. Whitmore,et al.  The response of metastatic adenocarcinoma of the prostate to exogenous testosterone. , 1981, The Journal of urology.

[22]  L. Zelkowitz,et al.  Bone 'flare,' hypercalcemia, and jaundice after tamoxifen therapy. , 1981, Archives of internal medicine.

[23]  C. Redmond,et al.  Treatment of primary breast cancer with chemotherapy and tamoxifen. , 1981, The New England journal of medicine.

[24]  B. Stoll.  The significance of tumour "stimulation" by tamoxifen. , 1980, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[25]  M. Tattersall,et al.  Hypercalcaemia after tamoxifen for breast cancer: a sign of tumour response? , 1979, British medical journal.

[26]  P. Band,et al.  Tamoxifen-induced tumor stimulation and withdrawal response. , 1979, Cancer treatment reports.

[27]  P. Rosen,et al.  Tamoxifen flare in advanced breast cancer. , 1978, JAMA.

[28]  H. Mouridsen,et al.  Tamoxifen in advanced breast cancer. , 1978, Cancer treatment reviews.

[29]  R. K. Knight,et al.  SAFETY OF TAMOXIFEN , 1978, The Lancet.

[30]  M. Baum,et al.  SAFETY OF TAMOXIFEN , 1978, The Lancet.

[31]  G. Bonadonna.  Tamoxifen: A Review of its Pharmacological Properties and Therapeutic Use in the Treatment of Breast Cancer , 1978 .

[32]  D. Kiang,et al.  Tamoxifen (antiestrogen) therapy in advanced breast cancer. , 1977, Annals of internal medicine.

[33]  G. Thynne,et al.  Tumour stimulation by anti‐oestrogens , 1977, The British journal of surgery.

[34]  A. Paccagnella,et al.  Tamoxifen in Disseminated Breast Cancer , 1977, Tumori.

[35]  E. Ferrazzí,et al.  Oestrogen-like effect of tamoxifen on vaginal epithelium. , 1977, British medical journal.

[36]  R. Simon,et al.  Evaluation of tamoxifen dose in advanced breast cancer: a progress report. , 1976, Cancer treatment reports.

[37]  P. Woolley,et al.  Therapeutic use of tamoxifen in advanced breast cancer: correlation with biochemical parameters. , 1976, Cancer treatment reports.

[38]  P. Band,et al.  Phase II study of tamoxifen: report of 74 patients with stage IV breast cancer. , 1976, Cancer treatment reports.

[39]  K.,et al.  A new derivative of triphenylethylene: effect on implantation and mode of action in rats. , 1967, Journal of reproduction and fertility.