VEGF-A isoforms differentially regulate ATF-2–dependent VCAM-1 gene expression and endothelial–leukocyte interactions

VEGF-A isoforms differentially stimulate endothelial VCAM-1 gene expression via an ERK1/2 protein kinase and ATF-2 transcription factor–dependent mechanism. Such signal transduction enables VEGF-A isoform–specific stimulation of leukocyte binding to endothelial cells, explaining how inflammation could be differentially regulated.

[1]  P. Berger,et al.  Coordination of VEGF receptor trafficking and signaling by coreceptors. , 2013, Experimental cell research.

[2]  A. Noël,et al.  New prospects in the roles of the C-terminal domains of VEGF-A and their cooperation for ligand binding, cellular signaling and vessels formation , 2013, Angiogenesis.

[3]  M Luisa Iruela-Arispe,et al.  Cellular and molecular regulation of vascular permeability , 2013, Thrombosis and Haemostasis.

[4]  H. Hurwitz,et al.  Anti-VEGF therapies in the clinic. , 2012, Cold Spring Harbor perspectives in medicine.

[5]  H. Seerapu,et al.  Regulation of VEGF signaling by membrane traffic. , 2012, Cellular signalling.

[6]  S. Koch,et al.  Signal transduction by vascular endothelial growth factor receptors. , 2012, Cold Spring Harbor perspectives in medicine.

[7]  Eric Lau,et al.  ATF2 – at the crossroad of nuclear and cytosolic functions , 2012, Journal of Cell Science.

[8]  J. Millán,et al.  Endothelial membrane reorganization during leukocyte extravasation , 2012, Cellular and Molecular Life Sciences.

[9]  B. Vojnovic,et al.  Use of the mouse aortic ring assay to study angiogenesis , 2011, Nature Protocols.

[10]  Napoleone Ferrara,et al.  Developmental and pathological angiogenesis. , 2011, Annual review of cell and developmental biology.

[11]  Corban G. Rivera,et al.  Analysis of VEGF-A Regulated Gene Expression in Endothelial Cells to Identify Genes Linked to Angiogenesis , 2011, PloS one.

[12]  R. Seger,et al.  The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. , 2011, Biochimica et biophysica acta.

[13]  C. Pellet-Many,et al.  VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation , 2011, Molecular biology of the cell.

[14]  L. Claesson‐Welsh,et al.  Signal transduction by vascular endothelial growth factor receptors. , 2011, The Biochemical journal.

[15]  N. Gamper,et al.  The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling. , 2011, Biochemical and biophysical research communications.

[16]  R. Krams,et al.  Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1: A Novel Mode of NF-&kgr;B Regulation That Promotes Arterial Inflammation , 2011, Circulation research.

[17]  H. Augustin,et al.  The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. , 2011, Blood.

[18]  J. Esko,et al.  Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability* , 2010, The Journal of Biological Chemistry.

[19]  Zev Rosenwaks,et al.  Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration , 2010, Nature.

[20]  A. Salameh,et al.  Growth Factor Stimulation Induces Cell Survival by c-Jun·ATF2-dependent Activation of Bcl-XL* , 2010, The Journal of Biological Chemistry.

[21]  Michael Sixt,et al.  Breaching multiple barriers: leukocyte motility through venular walls and the interstitium , 2010, Nature Reviews Molecular Cell Biology.

[22]  Tatiana Segura,et al.  Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells , 2010, The Journal of cell biology.

[23]  Shahin Rafii,et al.  Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors , 2010, Nature Reviews Cancer.

[24]  S. P. Herbert,et al.  Ligand‐Stimulated VEGFR2 Signaling is Regulated by Co‐Ordinated Trafficking and Proteolysis , 2010, Traffic.

[25]  S. Ponnambalam,et al.  VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis. , 2009, Biochemical Society transactions.

[26]  O. Wagner,et al.  The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation , 2009, Thrombosis and Haemostasis.

[27]  N. Hooper,et al.  Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[28]  Steven J. Harper,et al.  VEGF-A splicing: the key to anti-angiogenic therapeutics? , 2008, Nature Reviews Cancer.

[29]  W. Aird,et al.  Hepatocyte Growth Factor Inhibits VEGF-Forkhead–Dependent Gene Expression in Endothelial Cells , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[30]  U. Moens,et al.  Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility. , 2008, Cellular signalling.

[31]  Arthur Js.  MSK activation and physiological roles. , 2008 .

[32]  E. Morita,et al.  Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165 , 2008, Growth factors.

[33]  E. Dejana,et al.  Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis. , 2007, Biochimica et biophysica acta.

[34]  I. Evans,et al.  Vascular Endothelial Growth Factor Synergistically Enhances Induction of E-Selectin by Tumor Necrosis Factor-α , 2007 .

[35]  H. Otu,et al.  A Novel Class of Vascular Endothelial Growth Factor-responsive Genes That Require Forkhead Activity for Expression* , 2006, Journal of Biological Chemistry.

[36]  P. Hordijk.  Endothelial signalling events during leukocyte transmigration , 2006, The FEBS journal.

[37]  M. Sixt,et al.  Beta1 integrins: zip codes and signaling relay for blood cells. , 2006, Current opinion in cell biology.

[38]  Gareth Howell,et al.  Intrinsic Tyrosine Kinase Activity is Required for Vascular Endothelial Growth Factor Receptor 2 Ubiquitination, Sorting and Degradation in Endothelial Cells , 2006, Traffic.

[39]  M. Perrot-Applanat,et al.  VEGF189 stimulates endothelial cells proliferation and migration in vitro and up-regulates the expression of Flk-1/KDR mRNA. , 2005, Experimental cell research.

[40]  L. Cantley,et al.  Vascular Endothelial Growth Factor Induces Branching Morphogenesis/Tubulogenesis in Renal Epithelial Cells in a Neuropilin-Dependent Fashion , 2005, Molecular and Cellular Biology.

[41]  F. Carraro,et al.  Role of inflammatory mediators in angiogenesis. , 2005, Current drug targets. Inflammation and allergy.

[42]  Tom Maniatis,et al.  Crystal structure of ATF‐2/c‐Jun and IRF‐3 bound to the interferon‐β enhancer , 2004 .

[43]  S. P. Herbert,et al.  Endothelial cell confluence regulates Weibel-Palade body formation , 2004, Molecular membrane biology.

[44]  L. Claesson‐Welsh,et al.  The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration* , 2004, Journal of Biological Chemistry.

[45]  Susumu Ishida,et al.  VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. , 2004, Investigative ophthalmology & visual science.

[46]  Christopher C W Hughes,et al.  VEGF121 and VEGF165 Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor 2 in an in vitro Angiogenesis Model , 2003, Laboratory Investigation.

[47]  I. Zachary,et al.  Vascular Endothelial Growth Factor–Regulated Gene Expression in Endothelial Cells: KDR-Mediated Induction of Egr3 and the Related Nuclear Receptors Nur77, Nurr1, and Nor1 , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[48]  M. Bartoli,et al.  VEGF differentially activates STAT3 in microvascular endothelial cells , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  D. Gillatt,et al.  VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. , 2002, Cancer research.

[50]  G. Koh,et al.  Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression , 2001, Circulation research.

[51]  M. Shibuya,et al.  A single autophosphorylation site on KDR/Flk‐1 is essential for VEGF‐A‐dependent activation of PLC‐γ and DNA synthesis in vascular endothelial cells , 2001, The EMBO journal.

[52]  L. Glimcher,et al.  Decreased immediate inflammatory gene induction in activating transcription factor-2 mutant mice. , 2001, International immunology.

[53]  J. Schlessinger.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[54]  R Bicknell,et al.  The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo , 2000, British Journal of Cancer.

[55]  A. Griffioen,et al.  Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. , 2000, Pharmacological reviews.

[56]  Y. Nakatani,et al.  ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation , 2000, Nature.

[57]  Y. Yazaki,et al.  Vascular endothelial growth factor (VEGF) activates Raf‐1, mitogen‐activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes , 1998, Journal of cellular physiology.

[58]  N. Jones,et al.  p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. , 1998, Genes & development.

[59]  R. Jain,et al.  Leukocyte-endothelial adhesion and angiogenesis in tumors , 1996, Cancer and Metastasis Reviews.

[60]  Lieve Moons,et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.

[61]  Hung V. Nguyen,et al.  The Carboxyl-terminal Domain(111165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency (*) , 1996, The Journal of Biological Chemistry.

[62]  Janet Rossant,et al.  Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice , 1995, Nature.

[63]  T. Maniatis,et al.  Transcriptional regulation of endothelial cell adhesion molecules : NF-icB and cytokine-inducible enhancers , 2004 .

[64]  S. Wolfe.  The Biology of the Cell , 1981 .

[65]  D. Tomlinson,et al.  Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells. , 2014, Methods in enzymology.

[66]  Birger Herzoga,et al.  VEGF binding to NRP 1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP 1 and VEGFR 2 , and signaling via FAK Tyr 407 phosphorylation , 2011 .

[67]  J. Arthur.  MSK activation and physiological roles. , 2008, Frontiers in bioscience : a journal and virtual library.

[68]  Franklin Peale,et al.  Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. , 2007, Cancer cell.

[69]  I. Evans,et al.  Vascular endothelial growth factor synergistically enhances induction of E-selectin by tumor necrosis factor-alpha. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[70]  S. Harrison,et al.  Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. , 2004, The EMBO journal.

[71]  R. Jain,et al.  During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. , 1996, Nature medicine.

[72]  C. Weber.  Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction , 1996, Immunologic research.