Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

[1]  G. Carter,et al.  The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice , 2022, Frontiers in Aging Neuroscience.

[2]  Takashi D. Y. Kozai,et al.  Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease , 2021, Nature Communications.

[3]  William T. Ralvenius,et al.  APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia , 2021, Science Translational Medicine.

[4]  D. Hilt,et al.  A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator , 2021, British journal of clinical pharmacology.

[5]  Xiaojian Shi,et al.  ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism , 2021, Cell reports.

[6]  Sheina Emrani,et al.  APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review , 2020, Alzheimer's Research & Therapy.

[7]  J. Smiley,et al.  Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. , 2020, Cell reports.

[8]  M. Mann,et al.  Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. , 2020, Cell reports.

[9]  Jie Zan,et al.  Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice , 2020, Scientific Reports.

[10]  D. Holtzman,et al.  Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol , 2020, Proceedings of the National Academy of Sciences.

[11]  G. Perea,et al.  Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice , 2020, Molecular Neurodegeneration.

[12]  A. Fagan,et al.  APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline , 2020, Nature.

[13]  M. Wenk,et al.  Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning. , 2020, Cell reports.

[14]  Y. Asmann,et al.  Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways , 2020, Neuron.

[15]  Y. Asmann,et al.  APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid , 2020, Science Translational Medicine.

[16]  Steve Lianoglou,et al.  TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge , 2019, Neuron.

[17]  J. Gruenberg Life in the lumen: The multivesicular endosome , 2019, Traffic.

[18]  Xianlin Han,et al.  APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain , 2019, Alzheimer's Research & Therapy.

[19]  Jinsoo Seo,et al.  ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer’s Disease , 2019, Molecules and cells.

[20]  G. Bu,et al.  Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies , 2019, Nature Reviews Neurology.

[21]  D. Holtzman,et al.  Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia , 2019, bioRxiv.

[22]  W. Annaert,et al.  Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors , 2019, Molecular Neurodegeneration.

[23]  N. Sousa,et al.  Differential lipid composition and regulation along the hippocampal longitudinal axis , 2019, Translational Psychiatry.

[24]  Warren D. Smith,et al.  The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions , 2019, Health psychology and behavioral medicine.

[25]  D. Michaelson,et al.  ApoE4: an emerging therapeutic target for Alzheimer’s disease , 2019, BMC Medicine.

[26]  L. Goldstein,et al.  Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons , 2019, Cell stem cell.

[27]  E. Fraenkel,et al.  APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice , 2018, Scientific Reports.

[28]  P. Mathews,et al.  Apolipoprotein E4 genotype compromises brain exosome production , 2018, Brain : a journal of neurology.

[29]  Alexandre P. Blanchard,et al.  Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models , 2018, Journal of neurochemistry.

[30]  T. Südhof,et al.  Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease Risk , 2018, bioRxiv.

[31]  Siegfried Kasper,et al.  Spatial analysis and high resolution mapping of the human whole-brain transcriptome for integrative analysis in neuroimaging , 2018, NeuroImage.

[32]  R. Rao,et al.  Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH , 2018, Proceedings of the National Academy of Sciences.

[33]  L. Tsai,et al.  APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types , 2018, Neuron.

[34]  P. Hiesinger,et al.  Rab GTPases and Membrane Trafficking in Neurodegeneration , 2018, Current Biology.

[35]  R. Chan,et al.  Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model , 2018, Scientific Reports.

[36]  H. Riezman,et al.  Understanding the diversity of membrane lipid composition , 2018, Nature Reviews Molecular Cell Biology.

[37]  S. Small,et al.  Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures , 2018, Nature Communications.

[38]  M. Cookson,et al.  The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo , 2017, Front. Neurosci..

[39]  Yusuf A. Hannun,et al.  Sphingolipids and their metabolism in physiology and disease , 2017, Nature Reviews Molecular Cell Biology.

[40]  Geoffrey M. Barrett,et al.  Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology , 2017, Nature Communications.

[41]  Robert V Farese,et al.  Lipid Droplet Biogenesis. , 2017, Annual review of cell and developmental biology.

[42]  Irina Florina Tudorache,et al.  Apolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features , 2017, Computational and structural biotechnology journal.

[43]  I. Lodhi,et al.  Structural and functional roles of ether lipids , 2017, Protein & Cell.

[44]  A. Gitler,et al.  Defects in trafficking bridge Parkinson's disease pathology and genetics , 2016, Nature.

[45]  D. Krainc,et al.  Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons , 2016, The Journal of Neuroscience.

[46]  S. Gujja,et al.  Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation. , 2016, Cell reports.

[47]  E. Schon,et al.  ApoE4 upregulates the activity of mitochondria‐associated ER membranes , 2015, EMBO reports.

[48]  Bin Zhou,et al.  Molecular Substrates of Schizophrenia: Homeostatic Signaling to Connectivity , 2015, Molecular Psychiatry.

[49]  T. Eichmann,et al.  DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling , 2015, Cellular and Molecular Life Sciences.

[50]  S. Pääbo,et al.  Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues , 2015, Neuron.

[51]  Arthur W. Toga,et al.  Blood-Brain Barrier Breakdown in the Aging Human Hippocampus , 2015, Neuron.

[52]  M. Plourde,et al.  Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease? , 2014, Nutrients.

[53]  F. Hsieh,et al.  Di-22:6-bis(monoacylglycerol)phosphate: A clinical biomarker of drug-induced phospholipidosis for drug development and safety assessment. , 2014, Toxicology and applied pharmacology.

[54]  Derick R. Peterson,et al.  Plasma phospholipids identify antecedent memory impairment in older adults , 2014, Nature Medicine.

[55]  E. Reiman,et al.  Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease , 2013, Alzheimer's Research & Therapy.

[56]  R. Martins,et al.  Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ɛ3 and ɛ4 knock-in mice , 2013, Neurobiology of Aging.

[57]  S. Small,et al.  Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system , 2013, Nature Communications.

[58]  S. Niida,et al.  Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease , 2013, Lipids in Health and Disease.

[59]  Juan Antonio Vizcaíno,et al.  Shorthand notation for lipid structures derived from mass spectrometry , 2013, Journal of Lipid Research.

[60]  Daniel Weintraub,et al.  APOE ε4 increases risk for dementia in pure synucleinopathies. , 2013, JAMA neurology.

[61]  Berislav V. Zlokovic,et al.  Apolipoprotein E controls cerebrovascular integrity via cyclophilin A , 2012, Nature.

[62]  Markus R Wenk,et al.  Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease* , 2011, The Journal of Biological Chemistry.

[63]  G. Landreth,et al.  Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels* , 2011, The Journal of Biological Chemistry.

[64]  Lothar Willmitzer,et al.  Elemental formula annotation of polar and lipophilic metabolites using (13) C, (15) N and (34) S isotope labelling, in combination with high-resolution mass spectrometry. , 2011, The Plant journal : for cell and molecular biology.

[65]  J. Wuu,et al.  Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease , 2011, Journal of Chemical Neuroanatomy.

[66]  G. D. Paolo,et al.  Linking lipids to Alzheimer's disease: cholesterol and beyond , 2011, Nature Reviews Cancer.

[67]  David M Holtzman,et al.  Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance , 2011, Science Translational Medicine.

[68]  C. Catania,et al.  Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits , 2011, The Journal of Neuroscience.

[69]  G. D. Paolo,et al.  Linking lipids to Alzheimer's disease: cholesterol and beyond , 2011, Nature Reviews Neuroscience.

[70]  K. Wada,et al.  Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies , 2011, Journal of neuropathology and experimental neurology.

[71]  O. Arancio,et al.  Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits , 2010, The Journal of Neuroscience.

[72]  R. Martins,et al.  The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2, ε3 and ε4 knock-in mice , 2010, Neuroscience.

[73]  Yadong Huang,et al.  Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease. , 2010, Trends in molecular medicine.

[74]  Tiago Gil Oliveira,et al.  Phospholipase D in brain function and Alzheimer's disease. , 2010, Biochimica et biophysica acta.

[75]  L. Mucke,et al.  Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease , 2008, Nature Neuroscience.

[76]  A. Shevchenko,et al.  Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. , 2008, Journal of lipid research.

[77]  P. Meikle,et al.  Effect of lysosomal storage on bis(monoacylglycero)phosphate. , 2008, The Biochemical journal.

[78]  A. Fagan,et al.  Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β , 2005, Neurobiology of Disease.

[79]  D. Schmechel,et al.  Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice , 2004, Neuroscience.

[80]  Matthew P. Frosch,et al.  The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease , 2004, Neuron.

[81]  Xianlin Han,et al.  The role of apolipoprotein E in lipid metabolism in the central nervous system , 2004, Cellular and Molecular Life Sciences.

[82]  Xianlin Han,et al.  Novel Role for Apolipoprotein E in the Central Nervous System , 2003, The Journal of Biological Chemistry.

[83]  J. Touchon,et al.  The Relationship between Apolipoprotein E4 and Lipid Metabolism Is Impaired in Alzheimer’s Disease , 2001, Gerontology.

[84]  A. Fagan,et al.  Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[85]  A. Takeshita,et al.  Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. , 2000, Human molecular genetics.

[86]  S. Paul,et al.  Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition , 1997, Nature Genetics.

[87]  N. Maeda,et al.  Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis* , 1997, The Journal of Biological Chemistry.

[88]  T. Wisniewski,et al.  Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. , 1995, The Biochemical journal.

[89]  H. Brewer,et al.  Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments , 1994, Nature.

[90]  A D Roses,et al.  Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[91]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[92]  Hana L. Goldschmidt,et al.  Diacylglycerol, phosphatidic acid, and their metabolic enzymes in synaptic vesicle recycling. , 2015, Advances in biological regulation.

[93]  D. Michaelson,et al.  The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. , 2012, Journal of Alzheimer's disease : JAD.

[94]  J. Buxbaum,et al.  Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry. , 2010, Journal of Alzheimer's disease : JAD.

[95]  A. Fagan,et al.  Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. , 2005, Neurobiology of disease.

[96]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.

[97]  R. Mahley,et al.  Apolipoprotein E: far more than a lipid transport protein. , 2000, Annual review of genomics and human genetics.

[98]  S. Paul,et al.  Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. , 1997, Nature genetics.

[99]  J. Ma,et al.  Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. , 1994, Nature.