Calmodulin and protein kinases A/G mediate ciliary beat response in the human nasal epithelium

Mucociliary clearance of the airway epithelium is an essential function for mucosal defense. We recently proposed a hypothetical mechanism of ciliary beat regulation, in which the pannexin‐1 (Panx1)‐P2X7 unit serves as an oscillator generating a periodic increase in intracellular Ca2+ ([Ca2+]i). In the present study, we examined the localization of Panx1 and P2X7 at the ultrastructural level, and investigated the regulatory pathway subsequent to [Ca2+]i increase.

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