Cerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip

This work proposes a novel method for quantitative imaging of radioactivity on microfluidic chips by using visible light emission from Čerenkov radiation. Čerenkov radiation is generated when charged particles travel through an optically transparent material with a velocity greater than that of light in that material. It has been observed at UCLA that microfluidic chips used for 18F-related radio-synthesis studies have shown unidentified visible light emissions. In this study, the origin of the light was investigated and its feasibility as a quantitative imaging source was tested.

[1]  An elastomeric grating coupler , 2006 .

[2]  K. Markides,et al.  Radionuclide imaging of miniaturized chemical analysis systems. , 2004, Analytical chemistry.

[3]  G. Whitesides,et al.  Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies , 2003, Electrophoresis.

[4]  L. A. Currie,et al.  LIMITS FOR QUALITATIVE DETECTION AND QUANTITATIVE DETERMINATION. APPLICATION TO RADIOCHEMISTRY. , 1968 .

[5]  M.-A. Duval,et al.  Physical Performance of an Intraoperative Beta Probe Dedicated to Glioma Radioguided Surgery , 2008, IEEE Transactions on Nuclear Science.

[6]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[7]  R. R. Raylmann A solid-state intraoperative beta probe system , 2000 .

[8]  C. D'Orsi,et al.  Methods to calculate the lens efficiency in optically coupled CCD x-ray imaging systems. , 1994, Medical physics.

[9]  Y. Kvinnsland,et al.  A method for measurement of the uptake patterns of two beta-emitting radionuclides in the same tissue section with a digital silicon detector: application to a study of 89SrCl2 and 153Sm-EDTMP in a dog with spontaneous osteosarcoma , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[10]  J. Boone,et al.  Lens coupling efficiency: derivation and application under differing geometrical assumptions. , 1997, Medical physics.

[11]  Optimization of design parameters of a prototype CCD-based lens-coupled imaging system for the detection of beta particles in a microfluidic chip , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[12]  A. Breskin Advances in gas avalanche radiation detectors for biomedical applications , 2000 .

[13]  K. Markides,et al.  Imaging of peptide adsorption to microfluidic channels in a plastic compact disc using a positron emitting radionuclide. , 2005, Lab on a chip.

[14]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[15]  Y.H. Chung,et al.  Direct Detection of Beta Particles on a Microfluidic Chip using Position Sensitive APDs , 2006, 2006 IEEE Nuclear Science Symposium Conference Record.

[16]  E. Hoffman,et al.  Intraoperative beta probe: a device for detecting tissue labeled with positron or electron emitting isotopes during surgery. , 1994, Medical physics.

[17]  G. Knoll Radiation detection and measurement , 1979 .

[18]  H. Andersson,et al.  Microfluidic devices for cellomics: a review , 2003 .

[19]  Kevin Wells,et al.  Digital autoradiography using room temperature CCD and CMOS imaging technology , 2007, Physics in medicine and biology.

[20]  S. Quake,et al.  Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics , 2005, Science.

[21]  E. Hoffman,et al.  Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution. , 1999, Physics in medicine and biology.

[22]  Lloyd A. Currie,et al.  Limits for qualitative detection and quantitative determination , 1968 .

[23]  H. Ross Measurement of .beta.-emitting nuclides using Cerenkov radiation , 1969 .

[24]  H. Tseng,et al.  Performance of an integrated microfluidic chip and position sensitive APD for the detection of beta emitting probes in cell cultures , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.