Imaging cortical association tracts in the human brain using diffusion‐tensor‐based axonal tracking

Diffusion‐tensor fiber tracking was used to identify the cores of several long‐association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto‐occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X‐linked adrenoleukodystrophy) was demonstrated. Magn Reson Med 47:215–223, 2002. © 2002 Wiley‐Liss, Inc.

[1]  E. Crosby,et al.  Correlative Anatomy of the Nervous System , 1962 .

[2]  Walle J. H. Nauta,et al.  Connections of the Cerebral Cortex , 1964 .

[3]  Leslie G. Ungerleider,et al.  The inferior longitudinal fasciculus: A reexamination in humans and monkeys , 1985, Annals of neurology.

[4]  J. Tsuruda,et al.  Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. , 1990, Radiology.

[5]  R M Henkelman,et al.  Quantitative interpretation of magnetization transfer , 1993, Magnetic resonance in medicine.

[6]  C. Beaulieu,et al.  Determinants of anisotropic water diffusion in nerves , 1994, Magnetic resonance in medicine.

[7]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.

[8]  M. Bronskill,et al.  Anisotropy of NMR properties of tissues , 1994, Magnetic resonance in medicine.

[9]  P. Basser,et al.  Toward a quantitative assessment of diffusion anisotropy , 1996, Magnetic resonance in medicine.

[10]  P. Basser,et al.  Diffusion tensor MR imaging of the human brain. , 1996, Radiology.

[11]  M. Yașargil,et al.  Is there a superior occipitofrontal fasciculus? A microsurgical anatomic study. , 1997, Neurosurgery.

[12]  T. L. Davis,et al.  Morphometry of in vivo human white matter association pathways with diffusion‐weighted magnetic resonance imaging , 1997, Annals of neurology.

[13]  C Davatzikos,et al.  Mapping image data to stereotaxic spaces: Applications to brain mapping , 1998, Human brain mapping.

[14]  M. Horsfield,et al.  Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging , 1999, Magnetic resonance in medicine.

[15]  S C Williams,et al.  Non‐invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI , 1999, Magnetic resonance in medicine.

[16]  Alan C. Evans,et al.  Structural maturation of neural pathways in children and adolescents: in vivo study. , 1999, Science.

[17]  M. Solaiyappan,et al.  In vivo three‐dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging , 1999, Magnetic resonance in medicine.

[18]  P. V. van Zijl,et al.  Orientation‐independent diffusion imaging without tensor diagonalization: Anisotropy definitions based on physical attributes of the diffusion ellipsoid , 1999, Journal of magnetic resonance imaging : JMRI.

[19]  David N. Kennedy,et al.  MRI-Based Topographic Parcellation of Human Cerebral White Matter I. Technical Foundations , 1999, NeuroImage.

[20]  P. V. van Zijl,et al.  Three‐dimensional tracking of axonal projections in the brain by magnetic resonance imaging , 1999, Annals of neurology.

[21]  M. Raichle,et al.  Tracking neuronal fiber pathways in the living human brain. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  C. Westin,et al.  Multi‐component apparent diffusion coefficients in human brain † , 1999, NMR in biomedicine.

[23]  S Skare,et al.  Condition number as a measure of noise performance of diffusion tensor data acquisition schemes with MRI. , 2000, Journal of magnetic resonance.

[24]  Gjm. Parker,et al.  Tracing fibre tracts using fast marching. , 2000 .

[25]  V. Wedeen,et al.  Mapping fiber orientation spectra in cerebral white matter with Fourier-transform diffusion MRI , 2000 .

[26]  V. Wedeen,et al.  Fiber crossing in human brain depicted with diffusion tensor MR imaging. , 2000, Radiology.

[27]  P. Basser,et al.  In vivo fiber tractography using DT‐MRI data , 2000, Magnetic resonance in medicine.

[28]  Van J. Wedeen,et al.  A path inte-gral approach to white matter tractography , 2000 .

[29]  C. Poupon,et al.  Regularization of Diffusion-Based Direction Maps for the Tracking of Brain White Matter Fascicles , 2000, NeuroImage.

[30]  G. Pearlson,et al.  In vivo visualization of human neural pathways by magnetic resonance imaging , 2000, Annals of neurology.

[31]  G. Pearlson,et al.  Diffusion Tensor Imaging and Axonal Tracking in the Human Brainstem , 2001, NeuroImage.