THE DEVELOPMENT OF A MINIATURIZED WIRELESS MICRODIALYSIS-MICROCHIP ELECTROPHORESIS SYSTEM FOR IN VIVO MONITORING OF DRUGS AND NEUROTRANSMITTERS IN AWAKE AND FREELY MOVING SHEEP

This paper describes a novel miniaturized on-animal separation-based sensor using microdialysis coupled to microchip electrophoresis (MD-MCE) with electrochemical detection. In contrast to previous studies using MD-MCE in which animals need to be anesthetized or tethered to the microdialysis system, this work describes a miniaturized system employing telemetry that can be placed on-animal, making it possible for them to freely roam. The ultimate goal of this project is to be able to monitor biological analytes and correlate in vivo concentrations with the behavior of the freely roaming animal.