Metabolomics of AS‐5 RBC supernatants following routine storage

The safety and efficacy of stored red blood cells (RBCs) transfusion has been long debated due to retrospective clinical evidence and laboratory results, indicating a potential correlation between increased morbidity and mortality following transfusion of RBC units stored longer than 14 days. We hypothesize that storage in Optisol additive solution‐5 leads to a unique metabolomics profile in the supernatant of stored RBCs.

[1]  A. D’Alessandro,et al.  An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies , 2015, Transfusion.

[2]  J. Hess Measures of stored red blood cell quality , 2014, Vox sanguinis.

[3]  A. Spisni,et al.  Biochemical assessment of red blood cells during storage by (1)H nuclear magnetic resonance spectroscopy. Identification of a biomarker of their level of protection against oxidative stress. , 2014, Blood transfusion = Trasfusione del sangue.

[4]  T. Shlomi,et al.  Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.

[5]  James L. Newman,et al.  Metabolomics of ADSOL (AS-1) red blood cell storage. , 2014, Transfusion medicine reviews.

[6]  C. Natanson,et al.  Does prolonged storage of red blood cells cause harm? , 2014, British journal of haematology.

[7]  R. Sparrow,et al.  Longer storage of red blood cells is associated with increased in vitro erythrophagocytosis , 2014, Vox sanguinis.

[8]  P. Norris,et al.  In vitro measures of membrane changes reveal differences between red blood cells stored in saline‐adenine‐glucose‐mannitol and AS‐1 additive solutions: a paired study , 2014, Transfusion.

[9]  S. Sowemimo-Coker Evaluation of an experimental filter designed for improving the quality of red blood cells (RBCs) during storage by simultaneously removing white blood cells and immunomodulators and improving RBC viscoelasticity and Band 3 proteins , 2014, Transfusion.

[10]  H. Lutz,et al.  Mechanisms tagging senescent red blood cells for clearance in healthy humans , 2013, Front. Physiol..

[11]  E. Moore,et al.  Proteomic analysis of the supernatant of red blood cell units: the effects of storage and leucoreduction , 2013, Vox sanguinis.

[12]  Masaru Tomita,et al.  Dynamic Simulation and Metabolome Analysis of Long-Term Erythrocyte Storage in Adenine–Guanosine Solution , 2013, PloS one.

[13]  N. Lion,et al.  Red blood cell–derived microparticles isolated from blood units initiate and propagate thrombin generation , 2013, Transfusion.

[14]  A. D’Alessandro,et al.  Haemoglobin glycation (Hb1Ac) increases during red blood cell storage: a MALDI‐TOF mass‐spectrometry‐based investigation , 2013, Vox sanguinis.

[15]  A. D’Alessandro,et al.  Native protein complexes in the cytoplasm of red blood cells. , 2013, Journal of proteome research.

[16]  A. D’Alessandro,et al.  Red blood cell metabolism under prolonged anaerobic storage. , 2013, Molecular bioSystems.

[17]  O. Daescu,et al.  The proteomics and interactomics of human erythrocytes , 2013, Experimental biology and medicine.

[18]  J. Acker,et al.  Phospholipidomics reveals differences in glycerophosphoserine profiles of hypothermically stored red blood cells and microvesicles. , 2013, Biochimica et biophysica acta.

[19]  C. Silliman,et al.  Biological response modifiers in photochemically pathogen‐reduced versus untreated apheresis platelet concentrates , 2013, Transfusion.

[20]  A. D’Alessandro,et al.  Alterations of red blood cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM. , 2012, Journal of proteomics.

[21]  N. Lion,et al.  Subcellular fractionation of stored red blood cells reveals a compartment-based protein carbonylation evolution. , 2012, Journal of proteomics.

[22]  E. Lasonder,et al.  The proteome of erythrocyte-derived microparticles from plasma: new clues for erythrocyte aging and vesiculation. , 2012, Journal of proteomics.

[23]  Athanassios D. Velentzas,et al.  Effects of pre-storage leukoreduction on stored red blood cells signaling: a time-course evaluation from shape to proteome. , 2012, Journal of proteomics.

[24]  Karen Blyth,et al.  Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells , 2012, Nature.

[25]  R. Sparrow Time to revisit red blood cell additive solutions and storage conditions: a role for "omics" analyses. , 2012, Blood transfusion = Trasfusione del sangue.

[26]  L. Zolla,et al.  Red blood cell storage and cell morphology , 2012, Transfusion medicine.

[27]  A. D’Alessandro,et al.  Time-course investigation of SAGM-stored leukocyte-filtered red bood cell concentrates: from metabolism to proteomics , 2012, Haematologica.

[28]  C. Silliman,et al.  Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury , 2011, Transfusion.

[29]  C. Zinner,et al.  A mathematical model for lactate transport to red blood cells , 2011, The Journal of Physiological Sciences.

[30]  A. Verhoeven,et al.  An improved red blood cell additive solution maintains 2,3‐diphosphoglycerate and adenosine triphosphate levels by an enhancing effect on phosphofructokinase activity during cold storage , 2010, Transfusion.

[31]  Masaru Tomita,et al.  In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods. , 2009, Journal of biotechnology.

[32]  J. Vincent,et al.  Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality? , 2009, Transfusion.

[33]  L. Margaritis,et al.  Storage‐dependent remodeling of the red blood cell membrane is associated with increased immunoglobulin G binding, lipid raft rearrangement, and caspase activation , 2007, Transfusion.

[34]  R. Sparrow,et al.  Red blood cell (RBC) age at collection and storage influences RBC membrane‐associated carbohydrates and lectin binding , 2007, Transfusion.

[35]  I. Hassinen,et al.  Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates , 2007, Journal of Biological Chemistry.

[36]  Philip S Low,et al.  Mapping of glycolytic enzyme-binding sites on human erythrocyte band 3. , 2006, The Biochemical journal.

[37]  R. Sparrow,et al.  Reduced expression of CD47 on stored red blood cells , 2006, Transfusion.

[38]  T. Arai,et al.  Activities of Enzymes Related to the Malate–Aspartate Shuttle in the Blood Cells of Thoroughbred Horses Undergoing Training Exercise , 2001, Veterinary Research Communications.

[39]  I. Messana,et al.  Blood bank conditions and RBCs: the progressive loss of metabolic modulation , 2000, Transfusion.

[40]  G. Hankey,et al.  Homocysteine and vascular disease , 1999, The Lancet.

[41]  L. Zolla,et al.  Biochemistry of red cell aging in vivo and storage lesions , 2013 .

[42]  D. Böning,et al.  An optimized method for the assay of the red blood cell--age-related enzyme aspartate aminotransferase. , 2004, Laboratory hematology : official publication of the International Society for Laboratory Hematology.

[43]  V. Wiwanitkit Combined osmotic fragility and dichlorophenol-indolphenol test for hemoglobin disorder screening in Thai pregnant subjects: an appraisal. , 2004, Laboratory hematology : official publication of the International Society for Laboratory Hematology.

[44]  R. Farese,et al.  The in vitro red blood cell uptake of C-14-cortisol; studies of plasma protein binding of cortisol in normal and abnormal states. , 1962, The Journal of clinical investigation.