Brazilian green propolis improves gut microbiota dysbiosis and protects against sarcopenic obesity

Brazilian green propolis is an important honeybee product that is considered beneficial for health. Here, we examined the therapeutic potential of dietary supplementation with propolis against sarcopenic obesity using Db/Db mice.

[1]  A. Coats,et al.  Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2021 , 2021, Journal of cachexia, sarcopenia and muscle.

[2]  M. Fukui,et al.  Trans Fatty Acid Intake Induces Intestinal Inflammation and Impaired Glucose Tolerance , 2021, Frontiers in Immunology.

[3]  K. Fukaya,et al.  Pharmacokinetics and metabolism of cinnamic acid derivatives and flavonoids after oral administration of Brazilian green propolis in humans. , 2021, Food & function.

[4]  H. Kunugi,et al.  Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen , 2020, Foods.

[5]  Heng Tang,et al.  Kaempferide improves glycolipid metabolism disorder by activating PPARγ in high-fat-diet-fed mice. , 2020, Life sciences.

[6]  M. Fukui,et al.  Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model. , 2020, American journal of physiology. Gastrointestinal and liver physiology.

[7]  Huaqi Zhang,et al.  Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  J. Walter,et al.  Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review , 2019, Nutrients.

[9]  M. Fukui,et al.  Shortage of energy intake rather than protein intake is associated with sarcopenia in elderly patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort , 2018, Journal of diabetes.

[10]  Lanlan Chen,et al.  Gut microbiota mediates the anti-obesity effect of calorie restriction in mice , 2018, Scientific Reports.

[11]  C. Sohn,et al.  Relationship between osteosarcopenic obesity and dietary inflammatory index in postmenopausal Korean women: 2009 to 2011 Korea National Health and Nutrition Examination Surveys , 2018, Journal of clinical biochemistry and nutrition.

[12]  Frank B. Hu,et al.  Global aetiology and epidemiology of type 2 diabetes mellitus and its complications , 2018, Nature Reviews Endocrinology.

[13]  Visweswara Rao Pasupuleti,et al.  Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits , 2017, Oxidative medicine and cellular longevity.

[14]  T. Spector,et al.  Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain , 2017, International Journal of Obesity.

[15]  K. Yamazaki,et al.  Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice , 2016, BMC Complementary and Alternative Medicine.

[16]  G. Milligan,et al.  Metabolism meets immunity: The role of free fatty acid receptors in the immune system. , 2016, Biochemical pharmacology.

[17]  M. Fukui,et al.  The relationship between hepatic steatosis and skeletal muscle mass index in men with type 2 diabetes. , 2016, Endocrine journal.

[18]  J. Amaya-Farfan,et al.  Green propolis modulates gut microbiota, reduces endotoxemia and expression of TLR4 pathway in mice fed a high-fat diet. , 2015, Food research international.

[19]  H. Kitamura,et al.  Brazilian propolis extract increases leptin expression in mouse adipocytes. , 2015, Biomedical research.

[20]  Na-Ri Shin,et al.  Proteobacteria: microbial signature of dysbiosis in gut microbiota. , 2015, Trends in biotechnology.

[21]  N. Nakamura,et al.  Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study. , 2015, Biomedical reports.

[22]  T. van de Wiele,et al.  Butyricicoccus pullicaecorum, a butyrate producer with probiotic potential, is intrinsically tolerant to stomach and small intestine conditions. , 2014, Anaerobe.

[23]  S. Price,et al.  Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes. , 2014, The Journal of nutritional biochemistry.

[24]  N. Chandel,et al.  ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.

[25]  M. Colonna,et al.  Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. , 2013, Immunity.

[26]  M. Funaki,et al.  Mitochondrial dysfunction caused by saturated fatty acid loading induces myocardial insulin-resistance in differentiated H9c2 myocytes: a novel ex vivo myocardial insulin-resistance model. , 2013, Experimental cell research.

[27]  Dorothy D. Sears,et al.  Macrophage Glucose-6-Phosphate Dehydrogenase Stimulates Proinflammatory Responses with Oxidative Stress , 2013, Molecular and Cellular Biology.

[28]  A. M. James,et al.  Mitochondrial oxidative stress and the metabolic syndrome , 2012, Trends in Endocrinology & Metabolism.

[29]  K. Park,et al.  Sarcopenic Obesity: Prevalence and Association With Metabolic Syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA) , 2010, Diabetes Care.

[30]  D. Foureau,et al.  Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis1 , 2009, The Journal of Immunology.

[31]  Jerrold R. Turner,et al.  Intestinal mucosal barrier function in health and disease , 2009, Nature Reviews Immunology.

[32]  B. Morio,et al.  Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. , 2008, The Journal of clinical investigation.

[33]  Herbert Tilg,et al.  Adipocytokines: mediators linking adipose tissue, inflammation and immunity , 2006, Nature Reviews Immunology.

[34]  D. Nicholls.  The physiological regulation of uncoupling proteins. , 2006, Biochimica et biophysica acta.

[35]  J. E. Silva,et al.  Thermogenic mechanisms and their hormonal regulation. , 2006, Physiological reviews.

[36]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[37]  Kiyoshi Matsumoto,et al.  Strong antihyperglycemic effects of water-soluble fraction of Brazilian propolis and its bioactive constituent, 3,4,5-tri-O-caffeoylquinic acid. , 2004, Biological & pharmaceutical bulletin.

[38]  P. Besnard,et al.  Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP). , 1996, European journal of biochemistry.

[39]  A. A. Farooqui,et al.  Beneficial effects of propolis on human health and neurological diseases. , 2012, Frontiers in bioscience.

[40]  A. Vercesi,et al.  Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. , 2006, Biochimica et biophysica acta.

[41]  M. Micallef,et al.  Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. , 1998, Cancer detection and prevention.

[42]  G. Patel,et al.  Isolation and Characterization of an Anaerobic, Cellulolytic Microorganism, Acetivibrio cellulolyticus gen. nov., sp. nov.† , 1980 .