Breve historia de la bioinformática

Bioinformatics appears as the result of the indissoluble marriage between informatics technology and life sciences. Although it was conceived in principle to resolve questions such as the following: How to store and organize DNA sequences? How to find introns and exons in genomic DNA sequences? What conditions are required for the transcription of a specific gene? How learn more about the structure of a protein? How does it compare sequences of proteins or predict their structures?, currently the acquisition of new and improved computational tools has made it possible that bioinformatics will be key piece in applications such as genetic screening, molecular diagnosis, drug discovery and crop genetic improvement.

[1]  P. Bork,et al.  Bioinformatics in the post-sequence era , 2003, Nature Genetics.

[2]  S M Brown.  Get your bioinformatics on the Web! , 2000, BioTechniques.

[3]  R S LEDLEY,et al.  Digital electronic computers in biomedical science. , 1959, Science.

[4]  F. Sanger,et al.  The amino-acid sequence in the glycyl chain of insulin. , 1952, The Biochemical journal.

[5]  R. Britten,et al.  Gene regulation for higher cells: a theory. , 1969, Science.

[6]  L. Pauling,et al.  The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain. , 1951, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Joel B. Hagen,et al.  The origins of bioinformatics , 2000, Nature Reviews Genetics.

[8]  Richard J. Roberts.  The early days of bioinformatics publishing , 2000, Bioinform..

[9]  A. Turing.  The chemical basis of morphogenesis , 1952, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

[10]  Irena Kustrzeba − Wójcicka.  Bioinformatics: From arduous beginnings to molecular databases , 2007 .

[11]  M. O. Dayhoff,et al.  Atlas of protein sequence and structure , 1965 .

[12]  Robert S. Ledley,et al.  The Protein Information Resource , 2003, Nucleic Acids Res..

[13]  G. Gamow,et al.  The problem of information transfer from the nucleic acids to proteins. , 1956, Advances in biological and medical physics.

[14]  A. Szent-Gyorgyi,et al.  Role of proline in polypeptide chain configuration of proteins. , 1957, Science.

[15]  F. Sanger.  Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes. , 1959, Science.

[16]  N H Horowitz,et al.  On the Evolution of Biochemical Syntheses. , 1945, Proceedings of the National Academy of Sciences of the United States of America.

[17]  La bioinformática como herramienta para la investigación en salud humana , 2007 .