The molecular basis of eukaryotic transcription (Nobel Lecture).

I am deeply grateful for the honor bestowed on me by the Nobel Committee for Chemistry and the Royal Swedish Academy of Sciences. It is an honor I share with my collaborators. It is also recognition of the many who have contributed over the past quarter century to the study of transcription.

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[22]  D. Bushnell,et al.  Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II , 2004, Science.

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[24]  Michael R. Green,et al.  Yeast TAFII145 Functions as a Core Promoter Selectivity Factor, Not a General Coactivator , 1997, Cell.

[25]  K. Severinov,et al.  Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution , 1999, Cell.

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[28]  Joan W Conaway,et al.  The mammalian Mediator complex and its role in transcriptional regulation. , 2005, Trends in biochemical sciences.

[29]  K. Murakami,et al.  Structural Basis of Transcription Initiation: RNA Polymerase Holoenzyme at 4 Å Resolution , 2002, Science.

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[32]  Kevin Struhl,et al.  A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. , 2004, Molecular cell.

[33]  Grant J. Jensen,et al.  Yeast RNA Polymerase II at 5 Å Resolution , 1999, Cell.

[34]  R. Conaway,et al.  Transcription initiated by RNA polymerase II and purified transcription factors from liver. Cooperative action of transcription factors tau and epsilon in initial complex formation. , 1990, The Journal of biological chemistry.

[35]  R. Kornberg,et al.  Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones , 1987, Cell.

[36]  M. Grunstein,et al.  Nucleosome loss activates yeast downstream promoters in vivo , 1988, Cell.

[37]  Yang Li,et al.  A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II , 1994, Cell.