The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.

[1]  C. Lehmann,et al.  Short Communication: Tracking Tregs: Translocation of CD49b/LAG-3+ Type 1 T Regulatory Cells to the Gut-Associated Lymphoid Tissue of HIV+ Patients. , 2019, AIDS research and human retroviruses.

[2]  R. Flavell,et al.  Intestinal IFN‐&ggr;–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL‐10 in the inflamed guts of patients with inflammatory bowel disease , 2018, The Journal of allergy and clinical immunology.

[3]  M. Akdiş,et al.  Mechanisms of allergen-specific immunotherapy: Diverse mechanisms of immune tolerance to allergens. , 2018, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[4]  L. Jouneau,et al.  LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells , 2018, Immunity.

[5]  Ying Tang,et al.  Tr1 responses are elevated in asymptomatic H. pylori‐infected individuals and are functionally impaired in H. pylori‐gastric cancer patients , 2018, Experimental cell research.

[6]  M. Battaglia,et al.  Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction in mice and is safe and effective during acute viral infection , 2018, European journal of immunology.

[7]  Yu Huang,et al.  Function of T regulatory type 1 cells is down-regulated and is associated with the clinical presentation of coronary artery disease. , 2018, Human immunology.

[8]  J. Krueger,et al.  Proportion of CD4+CD49b+LAG-3+ Type 1 Regulatory T Cells in the Blood of Psoriasis Patients Inversely Correlates with Psoriasis Area and Severity Index. , 2018, The Journal of investigative dermatology.

[9]  M. Roncarolo,et al.  From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation , 2018, Annals of the New York Academy of Sciences.

[10]  Asli Korkmaz,et al.  Bacterially activated B‐cells drive T cell differentiation towards Tr1 through PD‐1/PD‐L1 expression , 2018, Molecular immunology.

[11]  Emma L. Smith,et al.  Peptide Immunotherapy for Type 1 Diabetes—Clinical Advances , 2018, Front. Immunol..

[12]  M. Roncarolo,et al.  Engineered T Regulatory Type 1 Cells for Clinical Application , 2018, Front. Immunol..

[13]  K. Davis,et al.  Identity and Diversity of Human Peripheral Th and T Regulatory Cells Defined by Single-Cell Mass Cytometry , 2018, The Journal of Immunology.

[14]  S. Howie,et al.  TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells , 2017, Science Signaling.

[15]  L. Wen,et al.  Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development , 2017, Proceedings of the National Academy of Sciences.

[16]  C. Beam,et al.  Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes , 2017, Science Translational Medicine.

[17]  M. Roncarolo,et al.  IL-10-Engineered Human CD4+ Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  S. Zheng,et al.  ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells , 2017, Nature Communications.

[19]  D. Ganea,et al.  Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf , 2017, PloS one.

[20]  Robert L. Tanguay,et al.  Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices. , 2017, Nature nanotechnology.

[21]  B. Chiang,et al.  Characterization of c-Maf+Foxp3− Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells , 2017, Scientific Reports.

[22]  S. McColl,et al.  Eomesodermin promotes the development of type 1 regulatory T (TR1) cells , 2017, Science Immunology.

[23]  Ping Zhang,et al.  Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[24]  K. Samitas,et al.  Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses , 2017, Proceedings of the National Academy of Sciences.

[25]  Neil D. Lawrence,et al.  Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria , 2017, Science Immunology.

[26]  A. Secchi,et al.  Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression , 2017, Journal of Translational Medicine.

[27]  Richard Bonneau,et al.  Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation , 2017, Nature Immunology.

[28]  Francis J. Huber,et al.  IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo , 2017, The Journal of Immunology.

[29]  D. Wraith,et al.  Tr1-Like T Cells – An Enigmatic Regulatory T Cell Lineage , 2016, Front. Immunol..

[30]  V. Kuchroo,et al.  Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. , 2016, Immunity.

[31]  A. Moore,et al.  Expanding antigen-specific regulatory networks to treat autoimmunity , 2016, Nature.

[32]  R. Kumar,et al.  Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology , 2016, PLoS pathogens.

[33]  C. Jorgensen,et al.  Nonclassical CD4+CD49b+ Regulatory T Cells as a Better Alternative to Conventional CD4+CD25+ T Cells To Dampen Arthritis Severity , 2016, The Journal of Immunology.

[34]  H. Ueno,et al.  Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. , 2015, Clinical immunology.

[35]  F. Romerio,et al.  Increased Frequency of CD49b/LAG-3(+) Type 1 Regulatory T Cells in HIV-Infected Individuals. , 2015, AIDS research and human retroviruses.

[36]  J. Correale,et al.  Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses , 2015, Cell.

[37]  A. Secchi,et al.  Generation of Donor-specific T Regulatory Type 1 Cells From Patients on Dialysis for Cell Therapy After Kidney Transplantation , 2015, Transplantation.

[38]  M. Levings,et al.  Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism , 2015, The Journal of Immunology.

[39]  C. Clish,et al.  Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α , 2015, Nature Medicine.

[40]  B. Bernstein,et al.  Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation , 2015, Nature.

[41]  R. Rizzo,et al.  HLA-G expression levels influence the tolerogenic activity of human DC-10 , 2015, Haematologica.

[42]  J. Ijzermans,et al.  Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors , 2015, Oncoimmunology.

[43]  D. Scott‐Algara,et al.  Phenotype alterations in regulatory T-cell subsets in primary HIV infection and identification of Tr1-like cells as the main interleukin 10-producing CD4+ T cells. , 2015, The Journal of infectious diseases.

[44]  J. Miyazaki,et al.  TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses , 2015, Nature Communications.

[45]  M. Roncarolo,et al.  Mixed chimerism evolution is associated with T regulatory type 1 (Tr1) cells in a β-thalassemic patient after haploidentical haematopoietic stem cell transplantation , 2014, Chimerism.

[46]  S. Rutz,et al.  Role of Blimp-1 in programing Th effector cells into IL-10 producers , 2014, The Journal of experimental medicine.

[47]  A. Foussat,et al.  Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis , 2014, Arthritis Research & Therapy.

[48]  B. Hemmer,et al.  IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1 , 2014, Nature Communications.

[49]  Ian Spendlove,et al.  CD55 Costimulation Induces Differentiation of a Discrete T Regulatory Type 1 Cell Population with a Stable Phenotype , 2013, The Journal of Immunology.

[50]  M. Roncarolo,et al.  Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells , 2013, Front. Immunol..

[51]  F. Gounari,et al.  Current status of interleukin-10 and regulatory T-cells in cancer , 2013, Current opinion in oncology.

[52]  R. Sun,et al.  Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice , 2013, Proceedings of the National Academy of Sciences.

[53]  K. Ladell,et al.  Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3− T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells , 2013, Mucosal Immunology.

[54]  R. Flavell,et al.  Transplant Tolerance to Pancreatic Islets Is Initiated in the Graft and Sustained in the Spleen , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[55]  S. Pellegrini,et al.  Type I interferon potentiates T‐cell receptor mediated induction of IL‐10‐producing CD4+ T cells , 2013, European journal of immunology.

[56]  T. Tamura,et al.  Egr‐2 transcription factor is required for Blimp‐1‐mediated IL‐10 production in IL‐27‐stimulated CD4+ T cells , 2013, European journal of immunology.

[57]  A. Rudensky,et al.  Regulatory T cells: recommendations to simplify the nomenclature , 2013, Nature Immunology.

[58]  Xiaozhe Han,et al.  Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. , 2013, Journal of autoimmunity.

[59]  Kumar Kuna,et al.  Research Highlights and Editors’ Picks , 2013 .

[60]  A. Foussat,et al.  Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease. , 2012, Gastroenterology.

[61]  S. Gregori,et al.  Human tolerogenic DC-10: perspectives for clinical applications , 2012, Transplantation research.

[62]  M. Roncarolo,et al.  Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[63]  H. Kiyono,et al.  Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon , 2012, PLoS pathogens.

[64]  A. Amirzargar,et al.  Regulatory T-cell subset analysis and profile of interleukin (IL)-10, IL-17 and interferon-gamma cytokine-producing cells in kidney allograft recipients with donor cells infusion , 2012, Clinical and Experimental Nephrology.

[65]  M. Atkinson,et al.  Rapamycin Combined with Anti-CD45RB mAb and IL-10 or with G-CSF Induces Tolerance in a Stringent Mouse Model of Islet Transplantation , 2011, PloS one.

[66]  C. Akdis,et al.  Immunological mechanisms of allergen‐specific immunotherapy , 2011, Allergy.

[67]  Changyou Wu,et al.  IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3. , 2011, Immunology letters.

[68]  A. Preisinger,et al.  ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors , 2011, Proceedings of the National Academy of Sciences.

[69]  Francis J. Huber,et al.  Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. , 2011, Immunity.

[70]  S. Cobbold Faculty Opinions recommendation of Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells. , 2011 .

[71]  L. Guidi,et al.  Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome , 2011, European journal of immunology.

[72]  C. Paties,et al.  Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy , 2010, Haematologica.

[73]  N. Delhem,et al.  Regulatory T cells in HBV and HCV liver diseases: implication of regulatory T lymphocytes in the control of immune response , 2010, Expert opinion on biological therapy.

[74]  D. Wraith,et al.  Antigen-specific immunotherapy of autoimmune and allergic diseases , 2010, Current opinion in immunology.

[75]  Graham M Lord,et al.  Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells , 2010, Nature Immunology.

[76]  E. Hauben,et al.  Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. , 2010, Blood.

[77]  S. Sehrawat,et al.  Immunity and immunopathology to viruses: what decides the outcome? , 2010, Nature Reviews Immunology.

[78]  T. Whiteside,et al.  Adenosine and Prostaglandin E2 Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells* , 2010, The Journal of Biological Chemistry.

[79]  G. Parmiani,et al.  LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites , 2010, The Journal of Immunology.

[80]  W. Guo,et al.  A Defect of CD4+CD25+ Regulatory T Cells in Inducing Interleukin-10 Production From CD4+ T Cells Under CD46 Costimulation in Asthma Patients , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[81]  S. Sumitomo,et al.  CD4+CD25-LAG-3+ T cells in mouse and human. , 2010, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

[82]  F. Wong,et al.  IFN-γ and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes , 2010, Diabetologia.

[83]  A. Skowera,et al.  Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression , 2010, Diabetes.

[84]  M. Roncarolo,et al.  Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites. , 2010, The Journal of allergy and clinical immunology.

[85]  A. Rudensky,et al.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate , 2010, Nature.

[86]  F. Fåk,et al.  A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells , 2010, PloS one.

[87]  M. Atkinson,et al.  Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant , 2009, Diabetes.

[88]  M. Roncarolo,et al.  Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia , 2009, Haematologica.

[89]  S. Sakaguchi,et al.  CD4+CD25−LAG3+ regulatory T cells controlled by the transcription factor Egr-2 , 2009, Proceedings of the National Academy of Sciences.

[90]  David E. Anderson,et al.  IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells1 , 2009, The Journal of Immunology.

[91]  V. Kuchroo,et al.  Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells1 , 2009, The Journal of Immunology.

[92]  A. Foussat,et al.  Clinical grade production of IL-10 producing regulatory Tr1 lymphocytes for cell therapy of chronic inflammatory diseases. , 2009, International immunopharmacology.

[93]  R. Anunu,et al.  CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells , 2008, The Journal of experimental medicine.

[94]  T. Whiteside,et al.  T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease , 2008, Clinical Cancer Research.

[95]  Yong‐jun Liu,et al.  Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. , 2008, Immunity.

[96]  H. Weiner,et al.  Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor , 2008, Nature.

[97]  M. V. von Herrath,et al.  Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. , 2008, Clinical immunology.

[98]  M. Batten,et al.  Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells , 2008, The Journal of Immunology.

[99]  H. Weiner,et al.  A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells , 2007, Nature Immunology.

[100]  Mohamed El-behi,et al.  Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells , 2007, Nature Immunology.

[101]  Christopher A Hunter,et al.  Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 , 2007, Nature Immunology.

[102]  A. Rudensky,et al.  Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10 , 2007, Nature Immunology.

[103]  M. Battaglia,et al.  Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 , 2006, The Journal of Immunology.

[104]  F. Sutterwala,et al.  Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. , 2006, Immunity.

[105]  G. Meiffren,et al.  Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. , 2006, The Journal of clinical investigation.

[106]  D. Roelen,et al.  The ratio of interferon-γ and interleukin-10 producing donor-specific cells as an in vitro monitoring tool for renal transplant patients , 2006 .

[107]  T. Huizinga,et al.  Immature Dendritic Cells Suppress Collagen-Induced Arthritis by In Vivo Expansion of CD49b+ Regulatory T Cells1 , 2006, The Journal of Immunology.

[108]  A. Camarca,et al.  Gliadin-Specific Type 1 Regulatory T Cells from the Intestinal Mucosa of Treated Celiac Patients Inhibit Pathogenic T Cells , 2006, The Journal of Immunology.

[109]  E. Bonifacio,et al.  Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells , 2006, Diabetes.

[110]  A. Foussat,et al.  Enhanced Frequency of CD18- and CD49b-Expressing T Cells in Peripheral Blood of Asthmatic Patients Correlates with Disease Severity , 2006, International Archives of Allergy and Immunology.

[111]  S. Oshima,et al.  Regulation of murine chronic colitis by CD4+CD25– programmed death‐1+ T cells , 2005, European journal of immunology.

[112]  M. Roncarolo,et al.  Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. , 2005, Blood.

[113]  A. O’Garra,et al.  IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. , 2004, The Journal of clinical investigation.

[114]  C. Akdis,et al.  Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells , 2004, The Journal of experimental medicine.

[115]  T. Banović,et al.  Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. , 2004, Blood.

[116]  Mark Peakman,et al.  Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. , 2004, The Journal of clinical investigation.

[117]  M. Moskowitz,et al.  Nasal Vaccination with Myelin Oligodendrocyte Glycoprotein Reduces Stroke Size by Inducing IL-10-Producing CD4+ T Cells1 , 2003, The Journal of Immunology.

[118]  P. Snow,et al.  Induction of Autoantigen-Specific Th2 and Tr1 Regulatory T Cells and Modulation of Autoimmune Diabetes1 , 2003, The Journal of Immunology.

[119]  M. Roncarolo,et al.  IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function. , 2003, Blood.

[120]  H. Groux,et al.  Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. , 2003, Immunity.

[121]  K. Murphy,et al.  Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype , 2003, Nature.

[122]  N. Netzer,et al.  Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading. , 2002, The Journal of clinical investigation.

[123]  A. Enk,et al.  CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. , 2002, Blood.

[124]  K. Mills,et al.  CD4 T helper type 1 and regulatory T cells induced against the same epitopes on the core protein in hepatitis C virus-infected persons. , 2002, The Journal of infectious diseases.

[125]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[126]  H. Groux,et al.  Differentiation of Regulatory T Cells 1 Is Induced by CD2 Costimulation1 , 2001, The Journal of Immunology.

[127]  R. de Waal Malefyt,et al.  IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells1 , 2001, The Journal of Immunology.

[128]  A. Enk,et al.  Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells , 2000, The Journal of experimental medicine.

[129]  F. Ruscetti,et al.  Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta. , 1999, Journal of immunology.

[130]  M. Roncarolo,et al.  A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. , 1999, Journal of immunology.

[131]  J. D. de Vries,et al.  Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. , 1998, Journal of immunology.

[132]  A. Enk,et al.  Induction of tolerance by IL-10-treated dendritic cells. , 1997, Journal of immunology.

[133]  Hervé Groux,et al.  A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.

[134]  S. Schultz-Cherry,et al.  Influenza virus neuraminidase activates latent transforming growth factor beta , 1996, Journal of virology.

[135]  J. D. de Vries,et al.  Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells , 1996, The Journal of experimental medicine.

[136]  C. Heusser,et al.  In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production. , 1994, Journal of immunology.

[137]  R. de Waal Malefyt,et al.  High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells , 1994, The Journal of experimental medicine.

[138]  C. Figdor,et al.  Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression , 1991, The Journal of experimental medicine.

[139]  T. Mosmann,et al.  Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[140]  J. Abrams,et al.  Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4. , 1990, Journal of immunology.

[141]  J. D. de Vries,et al.  Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera , 1988, The Journal of experimental medicine.

[142]  K. Nadeau,et al.  Peanut‐specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired , 2018, The Journal of allergy and clinical immunology.

[143]  A. Annoni,et al.  IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus. , 2016, The Journal of allergy and clinical immunology.

[144]  M. Battaglia,et al.  Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications. , 2014, Current topics in microbiology and immunology.

[145]  C. Akdis,et al.  In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure , 2008, The Journal of experimental medicine.