Defective IL‐12 production in mitogen‐activated protein (MAP) kinase kinase 3 (Mkk3)‐deficient mice
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I. Mellman | R. Flavell | Roger J. Davis | Hong-tao Lu | Derek D. Yang | M. Wysk | E. Gatti | R. Davis
[1] R. Flavell,et al. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[2] R. Flavell,et al. Defective T cell differentiation in the absence of Jnk1. , 1998, Science.
[3] P. Ricciardi-Castagnoli,et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.
[4] M. Rothe,et al. Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide , 1998, The Journal of experimental medicine.
[5] W. Lesslauer,et al. RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)* , 1998, The Journal of Biological Chemistry.
[6] P. Kalinski,et al. High-level IL-12 production by human dendritic cells requires two signals. , 1998, International immunology.
[7] E. Krebs,et al. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. , 1998, Journal of immunology.
[8] E. Nishida,et al. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. , 1998, Immunity.
[9] R. Flavell,et al. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. , 1998, Immunity.
[10] A. Gurney,et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling , 1998, Nature.
[11] R. Flavell,et al. The regulation of CD4 T cell differentiation. , 1998, European cytokine network.
[12] D. Alessi,et al. Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB , 1998, The EMBO journal.
[13] Yong Jiang,et al. PRAK, a novel protein kinase regulated by the p38 MAP kinase , 1998, The EMBO journal.
[14] L. Zon,et al. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[15] Y. Ip,et al. A Conserved p38 Mitogen-Activated Protein Kinase Pathway Regulates Drosophila Immunity Gene Expression , 1998, Molecular and Cellular Biology.
[16] M. Su,et al. Interferon‐γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway , 1998, The EMBO journal.
[17] E. Nishida,et al. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. , 1998, Science.
[18] A. Clerk,et al. The p38‐MAPK inhibitor, SB203580, inhibits cardiac stress‐activated protein kinases/c‐Jun N‐terminal kinases (SAPKs/JNKs) , 1998, FEBS letters.
[19] Anita B. Roberts,et al. REGULATION OF IMMUNE RESPONSES BY TGF-β* , 1998 .
[20] Y. Ip,et al. Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. , 1998, Current opinion in cell biology.
[21] G. Trinchieri,et al. Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages* , 1998, The Journal of Biological Chemistry.
[22] A. O’Garra,et al. Cytokines induce the development of functionally heterogeneous T helper cell subsets. , 1998, Immunity.
[23] G. Haegeman,et al. p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor* , 1998, The Journal of Biological Chemistry.
[24] J Ross,et al. Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family* , 1998, The Journal of Biological Chemistry.
[25] Roger J. Davis,et al. Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6* , 1998, The Journal of Biological Chemistry.
[26] W. Lesslauer,et al. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). , 1998, The Journal of biological chemistry.
[27] R. Flavell,et al. CD40 and CD154 in cell-mediated immunity. , 1998, Annual review of immunology.
[28] L Adorini,et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. , 1998, Annual review of immunology.
[29] G. Trinchieri. Interleukin-12: a cytokine at the interface of inflammation and immunity. , 1998, Advances in immunology.
[30] P. Young,et al. The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors. , 1997, Journal of immunology.
[31] Yong Jiang,et al. Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ* , 1997, The Journal of Biological Chemistry.
[32] N. Giese,et al. Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression , 1997, The Journal of experimental medicine.
[33] A. Sher,et al. Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction , 1997, The Journal of experimental medicine.
[34] R. Flavell,et al. T-cell subsets: transcriptional control in the Th1/Th2 decision. , 1997, Current biology : CB.
[35] J. Swantek,et al. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK , 1997, Molecular and cellular biology.
[36] M. Karin,et al. Regulation and function of the JNK subgroup of MAP kinases. , 1997, Biochimica et biophysica acta.
[37] P. Rakic,et al. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene , 1997, Nature.
[38] H. Nariuchi,et al. Differential effects of LPS and CD40 ligand stimulations on the induction of IL-12 production by dendritic cells and macrophages. , 1997, Cellular immunology.
[39] C. Manthey,et al. Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase* , 1997, The Journal of Biological Chemistry.
[40] P. Cohen,et al. The search for physiological substrates of MAP and SAP kinases in mammalian cells. , 1997, Trends in cell biology.
[41] R. Steinman,et al. Developmental regulation of MHC class II transport in mouse dendritic cells , 1997, Nature.
[42] M. Gately,et al. Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor. , 1997, Journal of immunology.
[43] S. Smale,et al. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins , 1997, Molecular and cellular biology.
[44] M E Greenberg,et al. A cytoplasmic inhibitor of the JNK signal transduction pathway. , 1997, Science.
[45] T. Hunter,et al. p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties* , 1997, The Journal of Biological Chemistry.
[46] Philip R. Cohen,et al. Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases , 1997, The EMBO journal.
[47] L. Rawlinson,et al. T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation* , 1997, The Journal of Biological Chemistry.
[48] T. Taniguchi,et al. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. , 1997, Immunity.
[49] G. Nemerow,et al. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. , 1997, Immunity.
[50] G. Bemis,et al. The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. , 1997, Chemistry & biology.
[51] T. Mak,et al. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. , 1997, Immunity.
[52] C. Zhang,et al. Mitogen-activated Protein (MAP) Kinase Regulates Production of Tumor Necrosis Factor-α and Release of Arachidonic Acid in Mast Cells , 1997, The Journal of Biological Chemistry.
[53] C. Zhang,et al. Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases. , 1997, The Journal of biological chemistry.
[54] L. Zon,et al. Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK* , 1997, The Journal of Biological Chemistry.
[55] Richard A Flavell,et al. The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.
[56] Steven A. Carr,et al. Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site* , 1997, The Journal of Biological Chemistry.
[57] M. Su,et al. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors , 1997, Molecular and cellular biology.
[58] G. Trinchieri,et al. Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter* , 1997, The Journal of Biological Chemistry.
[59] Jonathan A. Cooper,et al. Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 , 1997, The EMBO journal.
[60] Tony Hunter,et al. MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates , 1997, The EMBO journal.
[61] R. Flavell,et al. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[62] Jiahuai Han,et al. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation , 1997, Nature.
[63] Shengcai Lin,et al. Identification and characterization of a predominant isoform of human MKK3 , 1997, FEBS letters.
[64] C. Widmann,et al. MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? , 1997, Current opinion in genetics & development.
[65] C. Janeway,et al. Innate immunity: impact on the adaptive immune response. , 1997, Current opinion in immunology.
[66] T. Mak,et al. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3 , 1997, Nature.
[67] Philip R. Cohen,et al. Activation of stress‐activated protein kinase‐3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38) , 1997, The EMBO journal.
[68] C. Kuo,et al. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases , 1997, Molecular and cellular biology.
[69] M. Arkwysk,et al. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity , 1997 .
[70] U. Boehm,et al. Cellular responses to interferon-gamma. , 1997, Annual review of immunology.
[71] M. Gaestel,et al. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways , 1996, Molecular and cellular biology.
[72] Jiahuai Han,et al. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. , 1996, Biochemical and biophysical research communications.
[73] Y. Ip,et al. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. , 1996, Genes & development.
[74] Kenneth M. Murphy,et al. Functional diversity of helper T lymphocytes , 1996, Nature.
[75] R. Davis,et al. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways , 1996, Journal of Molecular Medicine.
[76] R. Dziarski,et al. Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan. , 1996, The Journal of infectious diseases.
[77] P. Cohen,et al. Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress‐ and cytokine‐stimulated monocytes and epithelial cells. , 1996, The EMBO journal.
[78] G. Schuler,et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10 [published erratum appears in J Exp Med 1996 Oct 1;184(4):following 1590] , 1996, The Journal of experimental medicine.
[79] A. Lanzavecchia,et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation , 1996, The Journal of experimental medicine.
[80] Wei Guo,et al. Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)* , 1996, The Journal of Biological Chemistry.
[81] M. Kaplan,et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.
[82] P. Doherty,et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells , 1996, Nature.
[83] D. Hume,et al. Endotoxin signal transduction in macrophages , 1996, Journal of leukocyte biology.
[84] L. Zon,et al. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. , 1996, Journal of immunology.
[85] K. Irie,et al. A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3* , 1996, The Journal of Biological Chemistry.
[86] Xiaozhong Wang,et al. Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase , 1996, Science.
[87] D. Young,et al. Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade (*) , 1996, The Journal of Biological Chemistry.
[88] D. Carvajal,et al. IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses , 1996 .
[89] John C. Lee,et al. Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase (*) , 1996, The Journal of Biological Chemistry.
[90] M. Goedert,et al. SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases , 1996, FEBS letters.
[91] W. Fiers,et al. The p38/RK mitogen‐activated protein kinase pathway regulates interleukin‐6 synthesis response to tumor necrosis factor. , 1996, The EMBO journal.
[92] P. Lehmann,et al. Induction of TH1 and TH2 Immunity in Neonatal Mice , 1996, Science.
[93] R. Davis,et al. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway , 1996, Molecular and cellular biology.
[94] Jiahuai Han,et al. Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6) (*) , 1996, The Journal of Biological Chemistry.
[95] M. Miller,et al. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. , 1996, Journal of immunology.
[96] John C. Lee,et al. Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms , 1996, Journal of leukocyte biology.
[97] G. Trinchieri,et al. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells , 1996, The Journal of experimental medicine.
[98] D. Carvajal,et al. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. , 1996, Immunity.
[99] Michael E. Greenberg,et al. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.
[100] K. Murphy,et al. Regulation of interleukin 12 p40 expression through an NF-kappa B half-site , 1995, Molecular and cellular biology.
[101] M. Karin,et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. , 1995, Science.
[102] Jiahuai Han,et al. Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*) , 1995, The Journal of Biological Chemistry.
[103] Jiahuai Han,et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms , 1995, Science.
[104] I. Herskowitz. MAP kinase pathways in yeast: For mating and more , 1995, Cell.
[105] R. Ulevitch,et al. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. , 1995, Annual review of immunology.
[106] G. Trinchieri. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. , 1995, Annual review of immunology.
[107] Jerry L. Adams,et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis , 1994, Nature.
[108] Michel Morange,et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins , 1994, Cell.
[109] J. Hsuan,et al. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27 , 1994, Cell.
[110] L Bibbs,et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. , 1994, Science.
[111] Masahiko Hibi,et al. JNK is involved in signal integration during costimulation of T lymphocytes , 1994, Cell.
[112] C. Hsieh,et al. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. , 1993, Science.
[113] M. Gately,et al. Regulation of human cytolytic lymphocyte responses by interleukin-12. , 1992, Cellular immunology.
[114] E. Unanue,et al. Interleukin 1 is processed and released during apoptosis. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[115] R. Hewick,et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. , 1991, Journal of immunology.
[116] T. Hunter,et al. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. , 1988, Science.