论文信息 - Inhibition of bone formation during space flight.

Inhibition of bone formation during space flight.

Parameters of bone formation and resorption were measured in rats orbited for 19.5 days aboard the Soviet Cosmos 782 biological satellite. The most striking effects were on bone formation. During flight, rats formed significantly less periosteal bone than did control rats on the ground. An arrest line at both the periosteum and the endosteum of flight animals suggest that a complete cessation of bone growth occurred. During a 26-day postflight period, the defect in bone formation was corrected. No significant changes in bone resorption were observed.

E R Morey | D J Baylink | D. Baylink | E. Morey

[1] D. Feldman,et al. Cytoplasmic glucocorticoid binding proteins in bone cells. , 1975, Endocrinology.

[2] J. Wergedal,et al. Decreased bone formation, mineralization, and enhanced resorption in calcium-deficient rats. , 1973, The American journal of physiology.

[3] D. Feldman,et al. Glucocorticoid receptors and inhibition of bone cell growth in primary culture. , 1977, Endocrinology.

[4] C. Rich,et al. Effect of calcitonin on the rates of bone formation and resorption in the rat. , 1969, Endocrinology.

[5] J. Burkhart,et al. Parathyroid and thyroid hormones in the development of immobilization osteoporosis. , 1967, Endocrinology.

[6] J M Vogel,et al. Effect of prolonged bed rest on bone mineral. , 1970, Metabolism: clinical and experimental.

[7] Yagodovsky Vs,et al. Space flight effects on skeletal bones of rats (light and electron microscopic examination). , 1976 .

[8] D. Rall,et al. Bone localization of the tetracyclines. , 1957, Journal of the National Cancer Institute.

[9] HighWire Press,et al. The journal of bone and joint surgery - British volume , 1948 .