Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia

Jak2 inhibitors are commonly used in the treatment of patients with myeloproliferative neoplasms, in particular patients with primary myelofibrosis and splenomegaly.[1][1] The currently available Jak2 inhibitors do not distinguish between wild-type (WT) Jak2 and mutant Jak2-V617F. Although a modest

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