Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
暂无分享,去创建一个
T. Kodama | Y. Yazaki | Y. Terauchi | T. Kadowaki | Y. Akanuma | K. Yasuda | K. Tobe | H. Tamemoto | Y. Kanazawa | K. Komeda | C. Ishii | T. Aizawa | K. Iwamoto | N. Asanuma
[1] Y. Yazaki,et al. Analysis of the Pancreatic β Cell in the Mouse with Targeted Disruption of the Pancreatic β Cell-Specific Glucokinase Gene , 1996 .
[2] M. McCarthy,et al. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families , 1996, Nature Genetics.
[3] N. Sonenberg,et al. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice , 1996, Molecular and cellular biology.
[4] R. S. Spielman,et al. A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 , 1996, Nature Genetics.
[5] J. Sturis,et al. Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. , 1996, The New England journal of medicine.
[6] T. Utsugi,et al. Beta-cell replication in insulin-induced remission of IDDM in BB/Wor//Tky rats , 1996 .
[7] Philippe Froguel,et al. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat , 1996, Nature Genetics.
[8] E. Lander,et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat , 1996, Nature Genetics.
[9] H. Kasai,et al. Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. , 1995, The Journal of biological chemistry.
[10] S. Haffner,et al. Decreased Insulin Secretion and Increased Insulin Resistance Are Independently Related to the 7-Year Risk of NIDDM in Mexican-Americans , 1995, Diabetes.
[11] C. Kahn,et al. Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (Nature (1994) 372 (186-190)) , 1994 .
[12] T. Yagi,et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.
[13] C. Kahn,et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.
[14] L. Bouwens,et al. Cytokeratins as Markers of Ductal Cell Differentiation and Islet Neogenesis in the Neonatal Rat Pancreas , 1994, Diabetes.
[15] D. Accili,et al. Insulin Resistance or Insulin Deficiency: Which Is the Primary Cause of NIDDM? , 1994, Diabetes.
[16] M. Komatsu,et al. ATP-sensitive K+ channel-independent glucose action in rat pancreatic beta-cell. , 1994, The American journal of physiology.
[17] E. Ravussin,et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.
[18] K. Kawano,et al. Spontaneous Long-Term Hyperglycemic Rat With Diabetic Complications: Otsuka Long-Evans Tokushima Fatty (OLETF) Strain , 1992, Diabetes.
[19] R. N. Bergman,et al. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study , 1992, The Lancet.
[20] M. Komatsu,et al. Dual Functional Role of Membrane Depolarization/Ca2+ Influx in Rat Pancreatic B-Cell , 1992, Diabetes.
[21] D. Porte,et al. Islet Function and Insulin Sensitivity in the Non‐diabetic Offspring of Conjugal Type 2 Diabetic Patients , 1990, Diabetic medicine : a journal of the British Diabetic Association.
[22] T. Toyota,et al. Impaired insulin secretion in the spontaneous diabetes rats. , 1982, The Tohoku journal of experimental medicine.