Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

[1]  A. Prokesch,et al.  Regulation of thermogenic adipocytes during fasting and cold , 2020, Molecular and Cellular Endocrinology.

[2]  Alexander S. Banks,et al.  A big-data approach to understanding metabolic rate and response to obesity in laboratory mice , 2019, bioRxiv.

[3]  Estifanos N. Habtemichael,et al.  GLUT4 Storage Vesicles: Specialized Organelles for Regulated Trafficking , 2019, The Yale journal of biology and medicine.

[4]  E. Wanker,et al.  Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1. , 2019, Structure.

[5]  A. Varshavsky N-degron and C-degron pathways of protein degradation , 2019, Proceedings of the National Academy of Sciences.

[6]  R. Hajjar,et al.  Enhancing atrial‐specific gene expression using a calsequestrin cis‐regulatory module 4 with a sarcolipin promoter , 2018, The journal of gene medicine.

[7]  C. Woodcock,et al.  The Role of Sarcolipin in Muscle Non-shivering Thermogenesis , 2018, Front. Physiol..

[8]  J. Wolenski,et al.  Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes , 2018, The Journal of Biological Chemistry.

[9]  K. Petersen,et al.  Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice , 2017, Proceedings of the National Academy of Sciences.

[10]  H. Meyer,et al.  VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. , 2017, Molecular cell.

[11]  D. Accili,et al.  Biochemical and cellular properties of insulin receptor signalling , 2017, Nature Reviews Molecular Cell Biology.

[12]  S. Kajimura,et al.  UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis , 2017, Nature Medicine.

[13]  M. Czech Insulin action and resistance in obesity and type 2 diabetes , 2017, Nature Medicine.

[14]  Wanqing Sun,et al.  Sestrin2 prevents age‐related intolerance to ischemia and reperfusion injury by modulating substrate metabolism , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[15]  S. Kuang,et al.  Muscle Histology Characterization Using H&E Staining and Muscle Fiber Type Classification Using Immunofluorescence Staining. , 2017, Bio-protocol.

[16]  Jian-Dong Huang,et al.  Adipose‐specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet‐induced obesity , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  S. Farmer,et al.  Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. , 2016, Cell metabolism.

[18]  Yingke Xu,et al.  Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action , 2016, Journal of Cell Science.

[19]  Estifanos N. Habtemichael,et al.  Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle* , 2015, The Journal of Biological Chemistry.

[20]  G. Shulman,et al.  Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-responsive Intracellular Compartment* , 2015, The Journal of Biological Chemistry.

[21]  B. Cannon,et al.  The browning of white adipose tissue: some burning issues. , 2014, Cell metabolism.

[22]  Estifanos N. Habtemichael,et al.  A proteolytic pathway that controls glucose uptake in fat and muscle , 2014, Reviews in Endocrine and Metabolic Disorders.

[23]  Kyung-A Hwang,et al.  Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation , 2013, Cell Death and Differentiation.

[24]  G. Shulman,et al.  Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. , 2013, American journal of physiology. Endocrinology and metabolism.

[25]  G. Shulman,et al.  Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle* , 2013, The Journal of Biological Chemistry.

[26]  B. Spiegelman,et al.  The Protein Level of PGC-1α, a Key Metabolic Regulator, Is Controlled by NADH-NQO1 , 2013, Molecular and Cellular Biology.

[27]  K. Petersen,et al.  Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. , 2013, Endocrinology.

[28]  Yuval Hart,et al.  The utility of paradoxical components in biological circuits. , 2013, Molecular cell.

[29]  C. Handschin,et al.  PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner , 2012, Diabetes.

[30]  Yan Wang,et al.  Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes , 2012, The Journal of cell biology.

[31]  J. Bogan Regulation of glucose transporter translocation in health and diabetes. , 2012, Annual review of biochemistry.

[32]  Alan R. Saltiel,et al.  Regulation of glucose transport by insulin: traffic control of GLUT4 , 2012, Nature Reviews Molecular Cell Biology.

[33]  C. Orme,et al.  Endoproteolytic Cleavage of TUG Protein Regulates GLUT4 Glucose Transporter Translocation* , 2012, The Journal of Biological Chemistry.

[34]  J. Quadrilatero,et al.  Rapid Determination of Myosin Heavy Chain Expression in Rat, Mouse, and Human Skeletal Muscle Using Multicolor Immunofluorescence Analysis , 2012, PloS one.

[35]  C. Orme,et al.  The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment* , 2011, The Journal of Biological Chemistry.

[36]  Robert V Farese,et al.  A guide to analysis of mouse energy metabolism , 2011, Nature Methods.

[37]  K. Kandror,et al.  The Sugar Is sIRVed: Sorting Glut4 and Its Fellow Travelers , 2011, Traffic.

[38]  Yingke Xu,et al.  Dual-mode of insulin action controls GLUT4 vesicle exocytosis , 2011, The Journal of cell biology.

[39]  D. Wasserman,et al.  The physiological regulation of glucose flux into muscle in vivo , 2011, Journal of Experimental Biology.

[40]  H. Hoppeler,et al.  Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Promotes Skeletal Muscle Lipid Refueling in Vivo by Activating de Novo Lipogenesis and the Pentose Phosphate Pathway* , 2010, The Journal of Biological Chemistry.

[41]  A. Schwartz,et al.  Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway* , 2010, The Journal of Biological Chemistry.

[42]  Cole Trapnell,et al.  Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.

[43]  C. S. Brower,et al.  Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations , 2009, PloS one.

[44]  Lior Pachter,et al.  Sequence Analysis , 2020, Definitions.

[45]  R. Hipskind,et al.  TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin , 2009, Journal of Cell Science.

[46]  Xudong Huang,et al.  A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle. , 2009, Endocrinology.

[47]  Israel Steinfeld,et al.  BMC Bioinformatics BioMed Central , 2008 .

[48]  Jiandie D. Lin,et al.  Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism , 2008, Proceedings of the National Academy of Sciences.

[49]  J. Ivy,et al.  Exercise training increases components of the c-Cbl-associated protein/c-Cbl signaling cascade in muscle of obese Zucker rats. , 2008, Metabolism: clinical and experimental.

[50]  S. Wakil,et al.  Continuous fat oxidation in acetyl–CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity , 2007, Proceedings of the National Academy of Sciences.

[51]  S. Yuasa,et al.  Intramolecular Control of Protein Stability, Subnuclear Compartmentalization, and Coactivator Function of Peroxisome Proliferator-activated Receptor γ Coactivator 1α* , 2007, Journal of Biological Chemistry.

[52]  J. Bogan,et al.  The Glucose Transporter 4-regulating Protein TUG Is Essential for Highly Insulin-responsive Glucose Uptake in 3T3-L1 Adipocytes* , 2007, Journal of Biological Chemistry.

[53]  J. Yates,et al.  Arginylation of ß-Actin Regulates Actin Cytoskeleton and Cell Motility , 2006, Science.

[54]  A. Gupte,et al.  Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes. , 2006, Biochemical and biophysical research communications.

[55]  D. Kelly,et al.  PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. , 2006, The Journal of clinical investigation.

[56]  D. Rivas,et al.  High-fat feeding effects on components of the CAP/Cbl signaling cascade in Sprague-Dawley rat skeletal muscle. , 2006, Metabolism: clinical and experimental.

[57]  A. Varshavsky,et al.  The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators , 2005, Nature.

[58]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[59]  D. James,et al.  Insulin Increases Cell Surface GLUT4 Levels by Dose Dependently Discharging GLUT4 into a Cell Surface Recycling Pathway , 2004, Molecular and Cellular Biology.

[60]  Xudong Huang,et al.  Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling. , 2004, Molecular endocrinology.

[61]  H. Lodish,et al.  Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking , 2003, Nature.

[62]  Jiandie D. Lin,et al.  Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells* , 2003, Journal of Biological Chemistry.

[63]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[64]  A. Butte,et al.  Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[65]  J. G. Park,et al.  Conventional kinesin KIF5B mediates insulin‐stimulated GLUT4 movements on microtubules , 2003, The EMBO journal.

[66]  G. Bray,et al.  The thermic effect of food is reduced in obesity. , 2002, Nutrition reviews.

[67]  Jiandie D. Lin,et al.  Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor* , 2002, The Journal of Biological Chemistry.

[68]  S. Keller,et al.  Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking. , 2001, The Journal of clinical endocrinology and metabolism.

[69]  H. Lodish,et al.  Insulin-Responsive Compartments Containing GLUT4 in 3T3-L1 and CHO Cells: Regulation by Amino Acid Concentrations , 2001, Molecular and Cellular Biology.

[70]  Makoto Kanzaki,et al.  Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 , 2001, Nature.

[71]  M. Kanzaki,et al.  CAP defines a second signalling pathway required for insulin-stimulated glucose transport , 2000, Nature.

[72]  Eric S. Lander,et al.  The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes , 2000, Nature Genetics.

[73]  P. Puigserver,et al.  Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. , 2000, Molecular cell.

[74]  B. Spiegelman,et al.  Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation* , 2000, The Journal of Biological Chemistry.

[75]  R. Weinberg,et al.  Generation of mammalian cells stably expressing multiple genes at predetermined levels. , 2000, Analytical biochemistry.

[76]  Bruce M. Spiegelman,et al.  Towards a molecular understanding of adaptive thermogenesis , 2000, Nature.

[77]  Guillaume Adelmant,et al.  Activation of PPARγ coactivator-1 through transcription factor docking , 1999 .

[78]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[79]  R. Prywes,et al.  Serum-Induced Expression of the cdc25AGene by Relief of E2F-Mediated Repression , 1999, Molecular and Cellular Biology.

[80]  A. Baron,et al.  Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. , 1998, The Journal of clinical investigation.

[81]  E. Yeh,et al.  Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein* , 1997, The Journal of Biological Chemistry.

[82]  J. Hill,et al.  Measuring the thermic effect of food. , 1996, The American journal of clinical nutrition.

[83]  A. Renold,et al.  Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice. , 1976, The Journal of clinical investigation.

[84]  I. Chaudry,et al.  Kinetics of glucose uptake in isolated soleus muscle. , 1969, Biochimica et Biophysica Acta.

[85]  Estifanos N. Habtemichael,et al.  Vasopressin inactivation: Role of insulin-regulated aminopeptidase. , 2020, Vitamins and hormones.

[86]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[87]  A. Saltiel,et al.  TC10α Is Required for Insulin-Stimulated Glucose Uptake in Adipocytes , 2006 .