The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design.

AIM This study examines the association between childhood physical abuse (CPA) and sexual abuse (CSA) and the development of cannabis abuse and dependence among adolescents and young adults while controlling for genetic and environmental risk factors. DESIGN To control for familial risk differences related to paternal drug dependence that might confound the relationship between CSA and CPA and cannabis abuse/dependence, we created four groups based on father's and uncle's substance use dependence (SUD) status reflecting different degrees of genetic and environmental risks to offspring: (i) high genetic, high environmental risk; (ii) high genetic, low environmental risk; (iii) medium genetic, low environmental risk; and (iv) low genetic, low environmental risk. PARTICIPANTS Adolescent and young adult offspring of monozygotic and dizygotic US military veteran twin fathers (n = 819). MEASUREMENTS Data on CPA and CSA, DSM-IV offspring cannabis abuse/dependence, other SUD and psychopathology and maternal and paternal SUD and psychopathology were collected via semi-structured telephone interview. FINDINGS Twenty-three per cent of the offspring sample met life-time criteria for cannabis abuse/dependence and 8.55% and 12.82% reported CSA and CPA, respectively. Offspring exposed to CSA, but not CPA, were at significantly greater risk of developing cannabis abuse/dependence compared to those who had not experienced CSA (hazard ratio = 2.16; 95% confidence interval = 1.48-3.16) after controlling for genetic and familial environmental risk and offspring gender, alcohol abuse and dependence and conduct disorder. CONCLUSIONS These results indicate that there are effects of CSA on development of cannabis abuse/dependence in addition to the genetic and familial environmental risk imparted by having a drug-dependent father.

[1]  Gail M. Williams,et al.  Does childhood sexual abuse have an effect on young adults' nicotine disorder (dependence or withdrawal)? Evidence from a birth cohort study. , 2007, Addiction.

[2]  N. Martin,et al.  Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study , 2006, Psychological Medicine.

[3]  D. Fergusson,et al.  Illicit Drug use and Dependence in a New Zealand Birth Cohort , 2006 .

[4]  S. Vuchinich,et al.  Associations between types of maltreatment and substance use during adolescence. , 2004, Child abuse & neglect.

[5]  H. MacMillan,et al.  The relationship between parental substance abuse and child maltreatment: findings from the Ontario Health Supplement. , 2003, Child abuse & neglect.

[6]  K. Bucholz,et al.  Genetic and environmental effects on offspring alcoholism: new insights using an offspring-of-twins design. , 2003, Archives of general psychiatry.

[7]  D. Chapman,et al.  Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the adverse childhood experiences study. , 2003, Pediatrics.

[8]  N. Breslau,et al.  Posttraumatic stress disorder and the incidence of nicotine, alcohol, and other drug disorders in persons who have experienced trauma. , 2003, Archives of general psychiatry.

[9]  D. Chapman,et al.  Adverse childhood experiences, alcoholic parents, and later risk of alcoholism and depression. , 2002, Psychiatric services.

[10]  V. Rickert,et al.  Effect of abuse on health: results of a national survey. , 2002, Archives of pediatrics & adolescent medicine.

[11]  W. Miller,et al.  Concomitance between childhood sexual and physical abuse and substance use problems. A review. , 2002, Clinical psychology review.

[12]  N. Martin,et al.  Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. , 2002, Archives of general psychiatry.

[13]  M Y Wong,et al.  Childhood abuse and lifetime psychopathology in a community sample. , 2001, The American journal of psychiatry.

[14]  Beth E. Molnar,et al.  Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey. , 2001, American journal of public health.

[15]  K. Kendler,et al.  Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. , 2000, Archives of general psychiatry.

[16]  K. Edgardh,et al.  Prevalence and characteristics of sexual abuse in a national sample of Swedish seventeen‐year‐old boys and girls , 2000, Acta paediatrica.

[17]  P. Schnurr,et al.  Risk factors for adolescent substance abuse and dependence: data from a national sample. , 2000, Journal of consulting and clinical psychology.

[18]  L. Bierut,et al.  Early sexual abuse and lifetime psychopathology: a co-twin–control study , 2000, Psychological Medicine.

[19]  S. Wonderlich,et al.  Prevalence and risk factors for childhood sexual abuse in women: national survey findings. , 1999, Child abuse & neglect.

[20]  K. Bucholz,et al.  Resiliency factors protecting against teenage alcohol use and smoking: influences of religion, religious involvement and values, and ethnicity in the Missouri Adolescent Female Twin Study , 1999, Twin Research.

[21]  M. Gissler,et al.  Boys have more health problems in childhood than girls: follow‐up of the 1987 Finnish birth cohort , 1999, Acta paediatrica.

[22]  S. Spieker,et al.  Self-reported abuse history and adolescent problem behaviors. II. Alcohol and drug use. , 1999, Journal of Adolescent Health.

[23]  J. Moncrieff,et al.  Sexual abuse and the subsequent development of alcohol problems. , 1998, Alcohol and alcoholism.

[24]  H. Resnick,et al.  PTSD as a mediator between childhood rape and alcohol use in adult women. , 1998, Child abuse & neglect.

[25]  T. Beebe,et al.  Multiple substance use among adolescent physical and sexual abuse victims. , 1997, Child abuse & neglect.

[26]  D. Fergusson,et al.  Childhood sexual abuse and psychiatric disorder in young adulthood: I. Prevalence of sexual abuse and factors associated with sexual abuse. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[27]  L J Horwood,et al.  Childhood sexual abuse and psychiatric disorder in young adulthood: II. Psychiatric outcomes of childhood sexual abuse. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[28]  R. Kessler,et al.  Posttraumatic stress disorder in the National Comorbidity Survey. , 1995, Archives of general psychiatry.

[29]  P. Grambsch,et al.  Proportional hazards tests and diagnostics based on weighted residuals , 1994 .

[30]  J. Nurnberger,et al.  A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. , 1994, Journal of studies on alcohol.

[31]  John P. Rice,et al.  Determining zygosity in the Vietnam Era Twin Registry: an approach using questionnaires , 1989, Clinical genetics.

[32]  S Greenland,et al.  Modeling and variable selection in epidemiologic analysis. , 1989, American journal of public health.

[33]  A. Scott,et al.  On Chi-Squared Tests for Multiway Contingency Tables with Cell Proportions Estimated from Survey Data , 1984 .

[34]  J. Stockman.  Child Maltreatment in the United States: Prevalence, Risk Factors, and Adolescent Health Consequences , 2008 .

[35]  D. Fergusson,et al.  Illicit drug use and dependence in a New Zealand birth cohort. , 2006, The Australian and New Zealand journal of psychiatry.

[36]  D G Kilpatrick,et al.  Risk factors for adolescent substance abuse and dependence: data from a national sample. , 2000, Journal of consulting and clinical psychology.

[37]  W R True,et al.  The Vietnam Era Twin Registry: a resource for medical research. , 1990, Public health reports.

[38]  J Goldberg,et al.  The Vietnam Era Twin (VET) Registry: method of construction. , 1987, Acta geneticae medicae et gemellologiae.

[39]  D. Cox.  Regression Models and Life-Tables , 1972 .

[40]  D.,et al.  Regression Models and Life-Tables , 2022 .