Hepatoprotective effect of Carica Papaya and Ficus Bengalensis Latex in Isoniazid as an antituberculosis drug Induced liver injury in Rats

: Hepatotoxicity is one of the major side effects of anti-tubercular drug like Isoniazid. The aim of Study was designed to evaluate the hepatoprotective activity of Carica Papaya Latex at the dose 400mg/k.g. and Ficus Bengalensis Latex at the dose 300mg/k.g. per oral induced by isoniazid at the dose 50mg/k.g. per oral. Group -I serve as a normal control received Saline 1ml/Kg. Group-II were received Isoniazid (50mg/kg.)per oral. Group-III were received Carica Papaya Latex 400mg/Kg. b.w./oral 30 min, prior to Isoniazid (50mg/kg .). Group-IV were received Ficus Bengalensis Latex 300mg/Kg./oral 30 min, prior to Isoniazid (50mg/kg .). Group-V were received Silymarin suspended in 1% of CMC 100mg/Kg./oral 30 min, prior to Isoniazid (50mg/kg .) in sterile saline once daily for 30 days. Animals were sacrificed on 30 days. Blood were collected by Cardiac puncture. Hepatoprotective activity was observed by using biochemical parameters such as Serum-Glutamate Pyruvate Transaminase and Serum-Glutamate Oxalate Transaminase (SGPT and SGOT), total protein, Bilirubin, Alkaline Phosphate (ALP). Carica papaya Latex and Ficus Bengalensis Latex formed major hepatoprotective effect by decreasing the activity of serum enzyme as SGPT, SGOT, Bilirubin, ALP, and prominent total protein level. Both plant latex were observed to prevent the toxic effect of Isoniazid on above serum parameters.

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