Vasomotion Spectra and Principal Components of Pooled Measures Predict Diabetes in monkeys

Diabetic neuropathy may be a result of disturbed vasomotion, the spontaneous rhythmic oscillations of vessel diameter, flow, or pressure in the microcirculation. To examine the differences in vasomotion prior to overt diabetes and with diagnosed diabetes, metabolic and blood flow measurements were obtained from three metabolically distinct groups of nonhuman primates: normoglycemic, metabolic syndrome/prediabetic, and overtly diabetic. Three of these indices characterize spectral properties of microcirculatory vasomotion: (1) the fraction of spectral power in a band around 2.0 Hz, (2) the ratio of spectral power in a band around 1.0 Hz to that around 2.0 Hz, (3) the Hurst exponent. The rest were more traditional measures including (4) fasting plasma Glucose (FPG), (5) glycosylated hemoglobin level (HbA1c), (6) fasting insulin levels (IRI), (7) average systolic blood pressure, and (8) average diastolic blood pressure. We found that the mean fraction of the spectral power of the vasomotion in the 2 Hz band ...

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