Advantages of Autologous Fascia versus Synthetic Patch Abdominal Reconstruction in Experimental Animal Defects
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&NA; Although prosthetic patches (i.e., expanded polytetrafluoroethylene) are commonly used to repair abdominal fascial defects, autologous tissue is preferred in the presence of wound contamination. This study was undertaken to discover (1) whether fascial grafts are revascularized and incorporated as living tissue, and (2) whether fascial grafts are more resistant to bacterial contamination than prosthetic patches. In the first experiment, 18 New Zealand White rabbits underwent full‐thickness resection of the central abdominal wall preserving only panniculus carnosus and skin. Six control animals had only skin repaired, and all developed large ventral hernias. Twelve animals had the defect repaired with thoracodorsal fascia patches. At 3‐ and 6‐week intervals, no hernias were present and all patches were incorporated with minimal contraction. Fluorescein angiography verified revascularization from the surrounding abdominal wall. Next, 36 rabbits underwent similar resection followed by repair with either autologous fascia (n = 18) or expanded polytetrafluoroethylene (n = 17). Six rabbits of each repair group were inoculated with 104 Staphylococcus aureus and twelve rabbits with each repair were inoculated with 109 S. aureus. All rabbits receiving 104 S. aureus were infectionfree survivors. Seven of the twelve expanded polytetrafluoroethylene‐repaired animals receiving 109 S. aureus developed necrotizing wound infections and died. Only 2 of 12 rabbits with autologous fascia repairs died from wound sepsis and 1 died of diarrhea with a healed wound. Differences in wound infection rates achieved statistical significance, whereas survival differences approached significance (Fisher's exact test), suggesting that revascularized fascial grafts may be more resistant to bacterial contamination than expanded polytetrafluoroethylene patches at this concentration (109 S. aureus). (Plast. Reconstr. Surg. 97: 801, 1996.)