Rehabilitation and Health Care Robotics

The field of rehabilitation robotics considers robotic systems that 1) provide therapy for persons seeking to recover their physical, social, communication, or cognitive function, and/or that 2) assist persons who have a chronic disability to accomplish activities of daily living. This chapter will discuss these two main domains and provide descriptions of the major achievements of the field over its short history and chart out the challenges to come. Specifically, after providing background information on demographics (Sect. 64.1.2) and history (Sect. 64.1.3) of the field, Sect. 64.2 describes physical therapy and exercise training robots, and Sect. 64.3 describes robotic aids for people with disabilities. Section 64.4 then presents recent advances in smart prostheses and orthoses that are related to rehabilitation robotics. Finally, Sect. 64.5 provides an overview of recent work in diagnosis and monitoring for rehabilitation as well as other health-care issues. The reader is referred to Chap. 73 for cognitive rehabilitation robotics and to Chap. 65 for robotic smart home technologies, which are often considered assistive technologies for persons with disabilities. At the conclusion of the present chapter, the reader will be familiar with the history of rehabilitation robotics and its primary accomplishments, and will understand the challenges the field may face in the future as it seeks to improve health care and the well being of persons with disabilities.

[1]  Vincent S. Huang,et al.  Robotic neurorehabilitation: a computational motor learning perspective , 2009, Journal of NeuroEngineering and Rehabilitation.

[2]  Jaap H. Buurke,et al.  Selective and adaptive robotic support of foot clearance for training stroke survivors with stiff knee gait , 2009, 2009 IEEE International Conference on Rehabilitation Robotics.

[3]  J. Patton,et al.  Evaluation of robotic training forces that either enhance or reduce error in chronic hemiparetic stroke survivors , 2005, Experimental Brain Research.

[4]  D.J. Reinkensmeyer,et al.  Automating Arm Movement Training Following Severe Stroke: Functional Exercises With Quantitative Feedback in a Gravity-Reduced Environment , 2006, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[5]  Iwan Ulrich,et al.  The GuideCane-applying mobile robot technologies to assist the visually impaired , 2001, IEEE Trans. Syst. Man Cybern. Part A.

[6]  S. K. Wee,et al.  Effects of a robot-assisted training of grasp and pronation/supination in chronic stroke: a pilot study , 2011, Journal of NeuroEngineering and Rehabilitation.

[7]  S Hesse,et al.  Repetitive locomotor training and physiotherapy improve walking and basic activities of daily living after stroke: a single-blind, randomized multicentre trial (DEutsche GAngtrainerStudie, DEGAS) , 2007, Clinical rehabilitation.

[8]  S.J. Harkema,et al.  An assistive robotic device that can synchronize to the pelvic motion during human gait training , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[9]  Adam Zoss,et al.  Prototype Medical Exoskeleton for Paraplegic Mobility: First Experimental Results , 2010 .

[10]  L. Sawaki,et al.  Use-dependent plasticity of the human motor cortex in health and disease , 2005, IEEE Engineering in Medicine and Biology Magazine.

[11]  D.J. Reinkensmeyer,et al.  Web-based telerehabilitation for the upper extremity after stroke , 2002, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[12]  M. Betke,et al.  The Camera Mouse: visual tracking of body features to provide computer access for people with severe disabilities , 2002, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[13]  J. Mehrholz,et al.  Electromechanical-assisted gait training after stroke: a systematic review comparing end-effector and exoskeleton devices. , 2012, Journal of rehabilitation medicine.

[14]  Kazuyoshi Wada,et al.  Special Issue on Assistive Robotics [From the Guest Editors] , 2013, IEEE Robotics Autom. Mag..

[15]  Lei Zhang,et al.  Twenty-year trends in the prevalence of disability in China. , 2011, Bulletin of the World Health Organization.

[16]  R. Stein,et al.  Reanimating limbs after injury or disease , 2005, Trends in Neurosciences.

[17]  D.J. Reinkensmeyer,et al.  Robot-enhanced motor learning: accelerating internal model formation during locomotion by transient dynamic amplification , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[18]  Z. Zenn Bien,et al.  Advances in Rehabilitation Robotics: Human-friendly Technologies on Movement Assistance and Restoration for People with Disabilities , 2004 .

[19]  David J. Reinkensmeyer,et al.  Robotic assist devices for bimanual physical therapy: preliminary experiments , 1993 .

[20]  E. Prassler Advances in Human-Robot Interaction , 2005 .

[21]  J. J. Gil,et al.  Lower-Limb Robotic Rehabilitation: Literature Review and Challenges , 2011, J. Robotics.

[22]  H. Harry Asada,et al.  The marionette bed: automated rolling and repositioning of bedridden patients , 2002, Proceedings 2002 IEEE International Conference on Robotics and Automation (Cat. No.02CH37292).

[23]  Loredana Zollo,et al.  Design of a planar robotic machine for neuro-rehabilitation , 2008, 2008 IEEE International Conference on Robotics and Automation.

[24]  M. Maležič,et al.  Treadmill training with partial body weight support compared with physiotherapy in nonambulatory hemiparetic patients. , 1995, Stroke.

[25]  W. Harwin,et al.  Multivariate analysis of the Fugl-Meyer outcome measures assessing the effectiveness of GENTLE/S robot-mediated stroke therapy , 2007, Journal of NeuroEngineering and Rehabilitation.

[26]  Roger Orpwood,et al.  The Weston wheelchair mounted assistive robot - the design story , 2002, Robotica.

[27]  T. Sato,et al.  Environment-type robot system "RoboticRoom" featured by behavior media, behavior contents, and behavior adaptation , 2004, IEEE/ASME Transactions on Mechatronics.

[28]  J. Mount,et al.  Body Weight‐Supported Treadmill Training Versus Conventional Gait Training for People With Chronic Traumatic Brain Injury , 2005, The Journal of head trauma rehabilitation.

[29]  T. Kline,et al.  Control system for pneumatically controlled glove to assist in grasp activities , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[30]  Dragoljub Surdilovic,et al.  STRING-MAN: a new wire robot for gait rehabilitation , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[31]  R. Simpson Smart wheelchairs: A literature review. , 2005, Journal of rehabilitation research and development.

[32]  Hiroshi Yokoi,et al.  Development of hand rehabilitation system using wire-driven link mechanism for paralysis patients , 2009, 2009 IEEE International Conference on Robotics and Biomimetics (ROBIO).

[33]  D.J. Reinkensmeyer,et al.  Optimizing Compliant, Model-Based Robotic Assistance to Promote Neurorehabilitation , 2008, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[34]  N. Hogan,et al.  Movement Smoothness Changes during Stroke Recovery , 2002, The Journal of Neuroscience.

[35]  Nevio Luigi Tagliamonte,et al.  Robomorphism: A Nonanthropomorphic Wearable Robot , 2014, IEEE Robotics & Automation Magazine.

[36]  Martin Buss,et al.  Compliant actuation of rehabilitation robots , 2008, IEEE Robotics & Automation Magazine.

[37]  H. Hok Kwee Integrated control of MANUS manipulator and wheelchair enhanced by environmental docking , 1998, Robotica.

[38]  R.C. Simpson,et al.  The Hephaestus Smart Wheelchair system , 2002, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[39]  Nicola Smania,et al.  Robot-Assisted Gait Training in Patients With Parkinson Disease , 2012, Neurorehabilitation and neural repair.

[40]  D. Khalili,et al.  An intelligent robotic system for rehabilitation of joints and estimation of body segment parameters , 1988, IEEE Transactions on Biomedical Engineering.

[41]  M.J. Mataric,et al.  Hands-off assistive robotics for post-stroke arm rehabilitation , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[42]  Brian Scassellati,et al.  The Grand Challenges in Socially Assistive Robotics , 2007 .

[43]  Floris Ernst,et al.  Medical Robotics , 2015, Springer International Publishing.

[44]  G. Lacey,et al.  User involvement in the design and evaluation of a smart mobility aid. , 2000, Journal of rehabilitation research and development.

[45]  R Jiménez-Fabián,et al.  Review of control algorithms for robotic ankle systems in lower-limb orthoses, prostheses, and exoskeletons. , 2012, Medical engineering & physics.

[46]  M. Micire,et al.  Development of Vision-Based Navigation for a Robotic Wheelchair , 2007, 2007 IEEE 10th International Conference on Rehabilitation Robotics.

[47]  W. Rymer,et al.  Robot-assisted reaching exercise promotes arm movement recovery in chronic hemiparetic stroke: a randomized controlled pilot study , 2006, Journal of NeuroEngineering and Rehabilitation.

[48]  Michael Hillman,et al.  Rehabilitation robotics from past to present - a historical perspective , 2003 .

[49]  Maureen K. Holden,et al.  Virtual Environments for Motor Rehabilitation: Review , 2005, Cyberpsychology Behav. Soc. Netw..

[50]  Haruhisa Kawasaki,et al.  A design of fine motion assist equipment for disabled hand in robotic rehabilitation system , 2011, J. Frankl. Inst..

[51]  M. Morari,et al.  Adaptive robotic rehabilitation of locomotion: a clinical study in spinally injured individuals , 2003, Spinal Cord.

[52]  Takanori Shibata,et al.  Psychophysiological Effects by Interaction with Mental Commit Robot , 2002, J. Robotics Mechatronics.

[53]  J.E. Colgate,et al.  KineAssist: a robotic overground gait and balance training device , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[54]  R.A. Cooper,et al.  Electric powered wheelchairs , 2005, IEEE Control Systems.

[55]  K. Mauritz,et al.  Treadmill training with partial body weight support and physiotherapy in stroke patients: a preliminary comparison , 2002, European journal of neurology.

[56]  T. Demott,et al.  Enhanced Gait-Related Improvements After Therapist- Versus Robotic-Assisted Locomotor Training in Subjects With Chronic Stroke: A Randomized Controlled Study , 2008, Stroke.

[57]  Hermano Igo Krebs,et al.  Characterization and control of a screw-driven robot for neurorehabilitation , 2001, Proceedings of the 2001 IEEE International Conference on Control Applications (CCA'01) (Cat. No.01CH37204).

[58]  H. Barbeau Locomotor Training in Neurorehabilitation: Emerging Rehabilitation Concepts , 2003, Neurorehabilitation and neural repair.

[59]  H. Loos Design and Engineering Ethics Considerations for Neurotechnologies , 2007 .

[60]  Curt Bay David Wu Expanding Tele-rehabilitation of Stroke Through In-home Robot-assisted Therapy , 2013 .

[61]  J. Mehrholz,et al.  Gait training with the newly developed ‘LokoHelp’-system is feasible for non-ambulatory patients after stroke, spinal cord and brain injury. A feasibility study , 2008, Brain injury.

[62]  António Paulo Moreira,et al.  IntellWheels: modular development platform for intelligent wheelchairs. , 2011, Journal of rehabilitation research and development.

[63]  H. Barbeau,et al.  A new approach to retrain gait in stroke patients through body weight support and treadmill stimulation. , 1998, Stroke.

[64]  Stefano Stramigioli,et al.  Lending a helping hand: toward novel assistive robotic arms , 2013, IEEE Robotics & Automation Magazine.

[65]  Jerry E. Pratt,et al.  Stiffness Isn't Everything , 1995, ISER.

[66]  Cordula Werner,et al.  Treadmill training with partial body-weight support after total hip arthroplasty: a randomized controlled trial. , 2003, Archives of physical medicine and rehabilitation.

[67]  David A. Bell,et al.  NavChair: An Assistive Wheelchair Navigation System with Automatic Adaptation , 1998, Assistive Technology and Artificial Intelligence.

[68]  P. Rossini,et al.  Double nerve intraneural interface implant on a human amputee for robotic hand control , 2010, Clinical Neurophysiology.

[69]  J. Edward Colgate,et al.  Cobot implementation of virtual paths and 3D virtual surfaces , 2003, IEEE Trans. Robotics Autom..

[70]  Eugenio Guglielmelli,et al.  Dynamic Characterization and Interaction Control of the CBM-Motus Robot for Upper-Limb Rehabilitation , 2013 .

[71]  U. Lindemann,et al.  Robotic-assisted rehabilitation of proximal humerus fractures in virtual environments , 2011, Zeitschrift für Gerontologie und Geriatrie.

[72]  T. Hornby,et al.  Clinical and Quantitative Evaluation of Robotic-Assisted Treadmill Walking to Retrain Ambulation After Spinal Cord Injury , 2005 .

[73]  Jose L Pons,et al.  Rehabilitation Exoskeletal Robotics , 2010, IEEE Engineering in Medicine and Biology Magazine.

[74]  David M. Walsh,et al.  Telemedicine, dementia and Down syndrome: Implications for Alzheimer disease , 2006, Alzheimer's & Dementia.

[75]  B. W. van Dijk,et al.  MEG-compatible force sensor , 2005, Journal of Neuroscience Methods.

[76]  J. Wolpaw,et al.  Activity-dependent spinal cord plasticity in health and disease. , 2001, Annual review of neuroscience.

[77]  H. Krebs,et al.  Effects of Robot-Assisted Therapy on Upper Limb Recovery After Stroke: A Systematic Review , 2008, Neurorehabilitation and neural repair.

[78]  J. Patton,et al.  Custom-designed haptic training for restoring reaching ability to individuals with poststroke hemiparesis. , 2006, Journal of rehabilitation research and development.

[79]  Grant D. Huang,et al.  Robot-assisted therapy for long-term upper-limb impairment after stroke. , 2010, The New England journal of medicine.

[80]  S Hesse,et al.  Electromechanical gait training with functional electrical stimulation: case studies in spinal cord injury , 2004, Spinal Cord.

[81]  Anson B. Rosenfeldt,et al.  Improving Quality of Life and Depression After Stroke Through Telerehabilitation. , 2015, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[82]  Jane Smith,et al.  The development of Handy 1, a rehabilitation robotic system to assist the severely disabled , 1998 .

[83]  Bruce H Dobkin,et al.  Body-weight-supported treadmill rehabilitation after stroke. , 2011, The New England journal of medicine.

[84]  W Seamone,et al.  Early clinical evaluation of a robot arm/worktable system for spinal-cord-injured persons. , 1985, Journal of rehabilitation research and development.

[85]  C. Mavroidis,et al.  MR_CHIROD v.2: Magnetic Resonance Compatible Smart Hand Rehabilitation Device for Brain Imaging , 2008, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[86]  S. Sugano,et al.  Design of an MRI compatible robot for finger rehabilitation , 2012, 2012 IEEE International Conference on Mechatronics and Automation.

[87]  Roger Weber,et al.  Tools for understanding and optimizing robotic gait training. , 2006, Journal of rehabilitation research and development.

[88]  Aude Billard,et al.  Robotic assistants in therapy and education of children with autism: can a small humanoid robot help encourage social interaction skills? , 2005, Universal Access in the Information Society.

[89]  Jon A. Mukand,et al.  Neuronal ensemble control of prosthetic devices by a human with tetraplegia , 2006, Nature.

[90]  Noriyuki Tejima Risk reduction mechanisms for safe rehabilitation robots , 2004 .

[91]  Chantal Ammi,et al.  27 Great Expectations for Rehabilitation Mechatronics in the Coming Decade , 2004 .

[92]  Paolo Bonato,et al.  A robotic hand rehabilitation system with interactive gaming using novel Electro-Rheological Fluid based actuators , 2010, 2010 IEEE International Conference on Robotics and Automation.

[93]  R. Riener,et al.  ARMin - design of a novel arm rehabilitation robot , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[94]  S. Micera,et al.  Robotic techniques for upper limb evaluation and rehabilitation of stroke patients , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[95]  Jörg Krüger,et al.  HapticWalker---a novel haptic foot device , 2005, TAP.

[96]  J. E. Colgate,et al.  Cobots: Robots for Collaboration With Human Operators , 1996, Dynamic Systems and Control.

[97]  D. Reinkensmeyer,et al.  Emerging Technologies for Improving Access to Movement Therapy following Neurologic Injury , 2002 .

[98]  Nevio Luigi Tagliamonte,et al.  Design and Characterization of a Novel High-Power Series Elastic Actuator for a Lower Limb Robotic Orthosis , 2013 .

[99]  Y. Matsuoka,et al.  Perceptual limits for a robotic rehabilitation environment using visual feedback distortion , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[100]  Hisato Kobayashi,et al.  Development of Sensate and Robotic Bed Technologies for Vital Signs Monitoring and Sleep Quality Improvement , 2003, Auton. Robots.

[101]  Vicky Chan,et al.  Robot-assisted Guitar Hero for finger rehabilitation after stroke , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[102]  Robert D. Lipschutz,et al.  The use of targeted muscle reinnervation for improved myoelectric prosthesis control in a bilateral shoulder disarticulation amputee , 2004, Prosthetics and orthotics international.

[103]  Paolo Dario,et al.  Effects of proximal and distal robot-assisted upper limb rehabilitation on chronic stroke recovery. , 2013, NeuroRehabilitation.

[104]  Gregory D. Abowd,et al.  Context-aware computing , 2002 .

[105]  Jan F. Veneman,et al.  The Effects on Kinematics and Muscle Activity of Walking in a Robotic Gait Trainer During Zero-Force Control , 2008, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[106]  S. Harkema,et al.  Locomotor training after human spinal cord injury: a series of case studies. , 2000, Physical therapy.

[107]  T. Milner,et al.  HandCARE: A Cable-Actuated Rehabilitation System to Train Hand Function After Stroke , 2008, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[108]  Holly A. Yanco,et al.  Wheelesley: A Robotic Wheelchair System: Indoor Navigation and User Interface , 1998, Assistive Technology and Artificial Intelligence.

[109]  B. Sjölund,et al.  Walking training of patients with hemiparesis at an early stage after stroke: a comparison of walking training on a treadmill with body weight support and walking training on the ground , 2001, Clinical rehabilitation.

[110]  Loredana Zollo,et al.  Patient-tailored adaptive robotic system for upper-limb rehabilitation , 2013, 2013 IEEE International Conference on Robotics and Automation.

[111]  N. Hogan,et al.  Robot-aided neurorehabilitation. , 1998, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[112]  Adam Zoss,et al.  Control and Experimental Results for Post Stroke Gait Rehabilitation With a Prototype Mobile Medical Exoskeleton , 2010 .

[113]  M Busnel,et al.  The robotized workstation "MASTER" for users with tetraplegia: description and evaluation. , 1999, Journal of rehabilitation research and development.

[114]  J. Edward Colgate,et al.  Cobot architecture , 2001, IEEE Trans. Robotics Autom..

[115]  Gianmarco Veruggio,et al.  The EURON Roboethics Roadmap , 2006, 2006 6th IEEE-RAS International Conference on Humanoid Robots.

[116]  Carl Helmers Robotics age, in the beginning : selected from Robotics age magazine , 1983 .

[117]  R. Andersen,et al.  Cognitive neural prosthetics. , 2010, Annual review of psychology.

[118]  F.A. Mussa-Ivaldi,et al.  Robotics and virtual reality: the development of a life-sized 3-D system for the rehabilitation of motor function , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[119]  Hermano Igo Krebs,et al.  Predicting efficacy of robot-aided rehabilitation in chronic stroke patients using an MRI-compatible robotic device , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[120]  Li-Chen Fu,et al.  An articulated rehabilitation robot for upper limb physiotherapy and training , 2010, 2010 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[121]  Manfred Morari,et al.  Automatic gait-pattern adaptation algorithms for rehabilitation with a 4-DOF robotic orthosis , 2004, IEEE Transactions on Robotics and Automation.

[122]  S.K. Agrawal,et al.  Theory and design of an orthotic device for full or partial gravity-balancing of a human leg during motion , 2004, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[123]  K. Wada,et al.  Effects of three months robot assisted activity to depression of elderly people who stay at a health service facility for the aged , 2004, SICE 2004 Annual Conference.

[124]  Dong-Soo Kwon,et al.  Integration of a Rehabilitation Robotic System (KARES II) with Human-Friendly Man-Machine Interaction Units , 2004, Auton. Robots.

[125]  W. Harwin,et al.  Effects of the Gentle/s Robot Mediated Therapy on the Outcome of Upper Limb Rehabilitation Post-Stroke: Analysis of the Battle Hospital Data , 2003 .

[126]  G. Gini,et al.  An EMG-controlled exoskeleton for hand rehabilitation , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[127]  C. Burgar,et al.  Robot-assisted movement training compared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke. , 2002, Archives of physical medicine and rehabilitation.

[128]  C. Burgar,et al.  Robot-assisted upper-limb therapy in acute rehabilitation setting following stroke: Department of Veterans Affairs multisite clinical trial. , 2011, Journal of rehabilitation research and development.

[129]  Hugh Herr,et al.  Exoskeletons and orthoses: classification, design challenges and future directions , 2009, Journal of NeuroEngineering and Rehabilitation.

[130]  S. P. Lum,et al.  The bimanual lifting rehabilitator: an adaptive machine for therapy of stroke patients , 1995 .

[131]  Judith E. Deutsch,et al.  Post-Stroke Rehabilitation with the Rutgers Ankle System: A Case Study , 2001, Presence: Teleoperators & Virtual Environments.

[132]  Iwan Ulrich,et al.  The GuideCane-a computerized travel aid for the active guidance of blind pedestrians , 1997, Proceedings of International Conference on Robotics and Automation.

[133]  Yoshiyuki Sankai,et al.  Power Assist System HAL-3 for Gait Disorder Person , 2002, ICCHP.

[134]  N. Hogan,et al.  Response to upper-limb robotics and functional neuromuscular stimulation following stroke. , 2005, Journal of rehabilitation research and development.

[135]  Paolo Dario,et al.  GIVING-A-HAND system: The development of a task-specific robot appliance , 2004 .

[136]  David Geer,et al.  Patient and staff acceptance of robotic technology in occupational therapy: a pilot study. , 1991, Journal of rehabilitation research and development.

[137]  C. Burgar,et al.  MIME robotic device for upper-limb neurorehabilitation in subacute stroke subjects: A follow-up study. , 2006, Journal of rehabilitation research and development.

[138]  G.A. Pratt,et al.  Series elastic actuator development for a biomimetic walking robot , 1999, 1999 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (Cat. No.99TH8399).

[139]  Matjaz Mihelj,et al.  Human arm kinematics for robot based rehabilitation , 2005, Robotica.

[140]  R. J. Gregor,et al.  Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat , 1986, Experimental Neurology.

[141]  Alin Albu-Schäffer,et al.  DLR's torque-controlled light weight robot III-are we reaching the technological limits now? , 2002, Proceedings 2002 IEEE International Conference on Robotics and Automation (Cat. No.02CH37292).

[142]  N. Hogan,et al.  Comparison of Two Techniques of Robot-Aided Upper Limb Exercise Training After Stroke , 2004, American journal of physical medicine & rehabilitation.

[143]  Loredana Zollo,et al.  Quantitative evaluation of upper-limb motor control in robot-aided rehabilitation , 2011, Medical & Biological Engineering & Computing.

[144]  Sunil K. Agrawal,et al.  Gait Rehabilitation With an Active Leg Orthosis , 2005 .

[145]  Frans C. T. van der Helm,et al.  A Series Elastic- and Bowden-Cable-Based Actuation System for Use as Torque Actuator in Exoskeleton-Type Robots , 2006, Int. J. Robotics Res..

[146]  L.J. Leifer,et al.  User testing and design iteration of the ProVAR user interface , 1999, 8th IEEE International Workshop on Robot and Human Interaction. RO-MAN '99 (Cat. No.99TH8483).

[147]  Nicola Smania,et al.  controlled trial instability in patients with mild to moderate Parkinson's disease: a single-blind randomized Robot-assisted gait training is not superior to balance training for improving postural , 2014 .

[148]  Anna D. Lockerd,et al.  Design evolution of an interactive robot for therapy. , 2004, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[149]  Elizabeth A. Croft,et al.  Independent ankle motion control improves robotic balance simulator , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[150]  N. Hogan,et al.  Robotic devices as therapeutic and diagnostic tools for stroke recovery. , 2009, Archives of neurology.

[151]  K. Dautenhahn,et al.  Towards interactive robots in autism therapy: background, motivation and challenges , 2004 .

[152]  Ian M. Mitchell,et al.  Design and use of assistive technology , 2010 .

[153]  William D. Smart,et al.  Robots for humanity: using assistive robotics to empower people with disabilities , 2013, IEEE Robotics & Automation Magazine.

[154]  H. F. Machiel Van der Loos,et al.  Construction of social relationships between user and robot , 2000, Robotics Auton. Syst..

[155]  Gabor Fazekas,et al.  A novel robot training system designed to supplement upper limb physiotherapy of patients with spastic hemiparesis , 2006, International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation.

[156]  F. H. Wilhelm,et al.  Ambulatory assessment of clinical anxiety , 1996 .

[157]  Rahsaan J. Holley,et al.  Development and pilot testing of HEXORR: Hand EXOskeleton Rehabilitation Robot , 2010, Journal of NeuroEngineering and Rehabilitation.

[158]  Michelle J. Johnson,et al.  Advances in upper limb stroke rehabilitation: a technology push , 2011, Medical & Biological Engineering & Computing.

[159]  J. M. Hammel The role of assessment and evaluation in rehabilitation robotics research and development: moving from concept to clinic to context , 1995 .

[160]  J. Hidler,et al.  Multicenter Randomized Clinical Trial Evaluating the Effectiveness of the Lokomat in Subacute Stroke , 2009, Neurorehabilitation and neural repair.

[161]  G.S. Dhillon,et al.  Direct neural sensory feedback and control of a prosthetic arm , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[162]  H. van der Kooij,et al.  Design and Evaluation of the LOPES Exoskeleton Robot for Interactive Gait Rehabilitation , 2007, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[163]  E. Guglielmelli,et al.  An inverse kinematics algorithm for upper-limb joint reconstruction during robot-aided motor therapy , 2012, 2012 4th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob).

[164]  K Corker,et al.  A preliminary evaluation of remote medical manipulators. , 1979, Bulletin of prosthetics research.

[165]  Huosheng Hu,et al.  Human motion tracking for rehabilitation - A survey , 2008, Biomed. Signal Process. Control..

[166]  G. Dudley,et al.  Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI , 2006, Neurology.

[167]  Hermano Igo Krebs,et al.  Rehabilitation Robotics: Performance-Based Progressive Robot-Assisted Therapy , 2003, Auton. Robots.

[168]  S. Micera,et al.  New technologies in manufacturing of different implantable microelectrodes as an interface to the peripheral nervous system , 2006, The First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006. BioRob 2006..

[169]  Fadia Haddad,et al.  Skeletal Muscle Plasticity: Cellular and Molecular Responses to Altered Physical Activity Paradigms , 2002, American journal of physical medicine & rehabilitation.

[170]  Joseph F. Engelberger,et al.  Health-care robotics goes commercial: the 'HelpMate' experience , 1993, Robotica.

[171]  S.C. Cramer,et al.  A robotic device for hand motor therapy after stroke , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[172]  J. Liu,et al.  Monitoring functional arm movement for home-based therapy after stroke , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[173]  N. Hogan,et al.  The effect of robot-assisted therapy and rehabilitative training on motor recovery following stroke. , 1997, Archives of neurology.

[174]  Robert Riener,et al.  Special section on rehabilitation via bio-cooperative control. , 2010, IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[175]  Luca Citi,et al.  Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses , 2014, Science Translational Medicine.

[176]  D. Reinkensmeyer,et al.  Arm-Training with T-WREX After Chronic Stroke: Preliminary Results of a Randomized Controlled Trial , 2007, 2007 IEEE 10th International Conference on Rehabilitation Robotics.

[177]  Rodolphe Gelin,et al.  The first moves of the AFMASTER workstation , 2001, Adv. Robotics.

[178]  Nevio Luigi Tagliamonte,et al.  Kinematic synthesis, optimization and analysis of a non-anthropomorphic 2-DOFs wearable orthosis for gait assistance , 2012, 2012 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[179]  Luís Paulo Reis,et al.  Adapted Control Methods for Cerebral Palsy Users of an Intelligent Wheelchair , 2015, J. Intell. Robotic Syst..

[180]  L. Zollo,et al.  Inter-hemispheric coupling changes associate with motor improvements after robotic stroke rehabilitation. , 2012, Restorative neurology and neuroscience.

[181]  D. Reinkensmeyer,et al.  Robotics for Gait Training After Spinal Cord Injury , 2005 .

[182]  Paolo Dario,et al.  Guest Editorial: Special Issue on Rehabilitation Robotics , 2003, Auton. Robots.

[183]  W. Rymer,et al.  Guidance-based quantification of arm impairment following brain injury: a pilot study. , 1999, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[184]  Grant D. Huang,et al.  An Economic Analysis of Robot-Assisted Therapy for Long-Term Upper-Limb Impairment After Stroke , 2011, Stroke.

[185]  J Guittet,et al.  The Spartacus telethesis: manipulator control studies. , 1979, Bulletin of prosthetics research.

[186]  J Kawamura,et al.  Automatic suspension device for gait training , 1993, Prosthetics and orthotics international.

[187]  I. Perkash,et al.  Evaluation of a vocational robot with a quadriplegic employee. , 1992, Archives of physical medicine and rehabilitation.

[188]  Steven C Cramer,et al.  Robotics, motor learning, and neurologic recovery. , 2004, Annual review of biomedical engineering.

[189]  S. Hesse,et al.  A mechanized gait trainer for restoration of gait. , 2000, Journal of rehabilitation research and development.

[190]  Sarah J. Housman,et al.  A Randomized Controlled Trial of Gravity-Supported, Computer-Enhanced Arm Exercise for Individuals With Severe Hemiparesis , 2009, Neurorehabilitation and neural repair.

[191]  Ethan R. Buch,et al.  Think to Move: a Neuromagnetic Brain-Computer Interface (BCI) System for Chronic Stroke , 2008, Stroke.

[192]  Maja J Matarić,et al.  Socially Assistive Robotics for Post-stroke Rehabilitation Journal of Neuroengineering and Rehabilitation Socially Assistive Robotics for Post-stroke Rehabilitation , 2007 .

[193]  Joseph F. Engelberger,et al.  Robotics in Service , 1989 .

[194]  C. Mathers,et al.  Stroke incidence and prevalence in Europe: a review of available data , 2006, European journal of neurology.

[195]  S C Jacobsen,et al.  Extended physiologic taction: design and evaluation of a proportional force feedback system. , 1989, Journal of rehabilitation research and development.

[196]  Gregory D. Abowd,et al.  Securing context-aware applications using environment roles , 2001, SACMAT '01.

[197]  H.J.A. Stuyt,et al.  Cost-savings and economic benefits due to the assistive robotic manipulator (ARM) , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[198]  Rolf Dieter Schraft,et al.  Care-O-bot II—Development of a Next Generation Robotic Home Assistant , 2004, Auton. Robots.

[199]  Alex Mihailidis,et al.  The development of an upper limb stroke rehabilitation robot: identification of clinical practices and design requirements through a survey of therapists , 2011, Disability and rehabilitation. Assistive technology.

[200]  Brian Scassellati,et al.  Socially assistive robotics [Grand Challenges of Robotics] , 2007, IEEE Robotics & Automation Magazine.

[201]  D.J. Reinkensmeyer,et al.  Control of a Pneumatic Orthosis for Upper Extremity Stroke Rehabilitation , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[202]  Paolo Dario,et al.  Design and experiments on a personal robotic assistant , 1998, Adv. Robotics.

[203]  Myer Kutz,et al.  Standard Handbook of Biomedical Engineering and Design , 2002 .

[204]  R Willms,et al.  Feasibility and efficacy of upper limb robotic rehabilitation in a subacute cervical spinal cord injury population , 2011, Spinal Cord.

[205]  Takanori Shibata,et al.  Subjective Evaluation of Seal Robot: Paro -Tabulation and Analysis of Questionnaire Results , 2002, J. Robotics Mechatronics.

[206]  Michael Kassler Introduction to the special issue on robotics for health care , 1993, Robotica.

[207]  L. Leifer,et al.  Clinical evaluation of a desktop robotic assistant. , 1989, Journal of rehabilitation research and development.

[208]  E. Burdet,et al.  Robot-assisted rehabilitation of hand function. , 2010, Current opinion in neurology.

[209]  N. Dechev,et al.  Design of a continuous passive and active motion device for hand rehabilitation , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[210]  Nevio Luigi Tagliamonte,et al.  A systematic graph-based method for the kinematic synthesis of non-anthropomorphic wearable robots for the lower limbs , 2010 .

[211]  S. Hesse,et al.  Treadmill Training With Partial Body Weight Support and an Electromechanical Gait Trainer for Restoration of Gait in Subacute Stroke Patients: A Randomized Crossover Study , 2002, Stroke.

[212]  G. Loeb,et al.  The BION devices: injectable interfaces with peripheral nerves and muscles. , 2006, Neurosurgical focus.

[213]  R. Gassert,et al.  MRI/fMRI-compatible robotic system with force feedback for interaction with human motion , 2006, IEEE/ASME Transactions on Mechatronics.

[214]  M. Goldfarb,et al.  Preliminary Evaluation of a Powered Lower Limb Orthosis to Aid Walking in Paraplegic Individuals , 2011, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[215]  C. A. Stanger,et al.  Demographics of rehabilitation robotics users , 1996 .

[216]  R. Andersen,et al.  Cognitive neural prosthetics. , 2010, Annual review of psychology.

[217]  B. Volpe,et al.  Kinematic Robot-Based Evaluation Scales and Clinical Counterparts to Measure Upper Limb Motor Performance in Patients With Chronic Stroke , 2010, Neurorehabilitation and neural repair.

[218]  M.J. Johnson,et al.  Experimental results using force-feedback cueing in robot-assisted stroke therapy , 2005, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[219]  D. Reinkensmeyer,et al.  Human-robot cooperative movement training: Learning a novel sensory motor transformation during walking with robotic assistance-as-needed , 2007, Journal of NeuroEngineering and Rehabilitation.

[220]  Loredana Zollo,et al.  Patient-Tailored Assistance: A New Concept of Assistive Robotic Device That Adapts to Individual Users , 2014, IEEE Robotics & Automation Magazine.

[221]  V. Sanguineti,et al.  Learning, Retention, and Slacking: A Model of the Dynamics of Recovery in Robot Therapy , 2012, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[222]  Katherine M. Tsui,et al.  Survey of domain-specific performance measures in assistive robotic technology , 2008, PerMIS.

[223]  Daniel P. Ferris,et al.  Powered lower limb orthoses for gait rehabilitation. , 2005, Topics in spinal cord injury rehabilitation.

[224]  Aaron M. Dollar,et al.  Lower Extremity Exoskeletons and Active Orthoses: Challenges and State-of-the-Art , 2008, IEEE Transactions on Robotics.

[225]  Eric Dishman,et al.  Inventing wellness systems for aging in place , 2004, Computer.

[226]  V. Dietz,et al.  Treadmill training of paraplegic patients using a robotic orthosis. , 2000, Journal of rehabilitation research and development.

[227]  M. Guadagnoli,et al.  Challenge Point: A Framework for Conceptualizing the Effects of Various Practice Conditions in Motor Learning , 2004, Journal of motor behavior.

[228]  Kelly P Westlake,et al.  Pilot study of Lokomat versus manual-assisted treadmill training for locomotor recovery post-stroke , 2009, Journal of NeuroEngineering and Rehabilitation.

[229]  P. Langhorne,et al.  Motor recovery after stroke: a systematic review , 2009, The Lancet Neurology.

[230]  V. Dietz,et al.  Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial , 2014, The Lancet Neurology.

[231]  Hermano Igo Krebs,et al.  A robot for wrist rehabilitation , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[232]  V. Dietz,et al.  Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. , 2005, Archives of physical medicine and rehabilitation.

[233]  N. Hogan,et al.  Effects of robotic therapy on motor impairment and recovery in chronic stroke. , 2003, Archives of physical medicine and rehabilitation.

[234]  J. Mehrholz,et al.  Computerized Arm Training Improves the Motor Control of the Severely Affected Arm After Stroke: A Single-Blinded Randomized Trial in Two Centers , 2005, Stroke.

[235]  Eugenio Guglielmelli,et al.  Multimodal Interfaces to Improve Therapeutic Outcomes in Robot-Assisted Rehabilitation , 2014, Technology Transfer Experiments from the ECHORD Project.

[236]  S P Levine,et al.  The NavChair Assistive Wheelchair Navigation System. , 1999, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[237]  Mark Huang,et al.  Advances in amputee care. , 2006, Archives of physical medicine and rehabilitation.

[238]  Antoinette Domingo,et al.  Reliability and validity of using the Lokomat to assess lower limb joint position sense in people with incomplete spinal cord injury , 2014, Journal of NeuroEngineering and Rehabilitation.

[239]  J. Wolpaw Chapter 64 Brain-computer interfaces (BCIs) for communication and control: a mini-review , 2004 .

[240]  S. Kirker,et al.  A new electromechanical trainer for sensorimotor rehabilitation of paralysed fingers: A case series in chronic and acute stroke patients , 2008, Journal of NeuroEngineering and Rehabilitation.

[241]  Hermano I Krebs,et al.  Robotic Measurement of Arm Movements After Stroke Establishes Biomarkers of Motor Recovery , 2014, Stroke.

[242]  P. Kennedy,et al.  Restoration of neural output from a paralyzed patient by a direct brain connection , 1998, Neuroreport.

[243]  Kazuo Kiguchi,et al.  SUEFUL-7: A 7DOF upper-limb exoskeleton robot with muscle-model-oriented EMG-based control , 2009, 2009 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[244]  Francois Routhier,et al.  Evaluation of the JACO robotic arm: Clinico-economic study for powered wheelchair users with upper-extremity disabilities , 2011, 2011 IEEE International Conference on Rehabilitation Robotics.

[245]  Alex Mihailidis,et al.  Evaluation of an intelligent wheelchair system for older adults with cognitive impairments , 2013, Journal of NeuroEngineering and Rehabilitation.

[246]  A Roby-Brami,et al.  A Methodology to Quantify Alterations in Human Upper Limb Movement During Co-Manipulation With an Exoskeleton , 2010, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[247]  David J. Reinkensmeyer,et al.  Optimization of a Parallel Shoulder Mechanism to Achieve a High-Force, Low-Mass, Robotic-Arm Exoskeleton , 2010, IEEE Transactions on Robotics.

[248]  He Huang,et al.  Utilization of biomechanical modeling in design of robotic arm for rehabilitation of stroke patients. , 2004, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.

[249]  Etienne Burdet,et al.  Rehabilitation of grasping and forearm pronation/supination with the Haptic Knob , 2009, 2009 IEEE International Conference on Rehabilitation Robotics.

[250]  Yoshihiro Kusuda How Japan sees the robotics for the future: observation at the World Expo 2005 , 2006, Ind. Robot.

[251]  J.C. Perry,et al.  Upper-Limb Powered Exoskeleton Design , 2007, IEEE/ASME Transactions on Mechatronics.

[252]  Jesse Hoey,et al.  NOAH for Wheelchair Users with Cognitive Impairment: Navigation and Obstacle Avoidance Help , 2008, AAAI Fall Symposium: AI in Eldercare: New Solutions to Old Problems.

[253]  Gregory D. Abowd,et al.  Context-aware computing [Guest Editors' Intro.] , 2002, IEEE Pervasive Computing.

[254]  Xin Feng,et al.  UniTherapy: a computer-assisted motivating neurorehabilitation platform for teleassessment and remote therapy , 2005, 9th International Conference on Rehabilitation Robotics, 2005. ICORR 2005..

[255]  Eugenio Guglielmelli,et al.  Guest Editorial Special Issue on Rehabilitation Robotics , 2009, IEEE Trans. Robotics.

[256]  Joseph Tiran,et al.  The Jerusalem TeleRehabilitation System, a New Low-Cost, Haptic Rehabilitation Approach , 2006, Cyberpsychology Behav. Soc. Netw..

[257]  S. Masiero,et al.  Robotic-assisted rehabilitation of the upper limb after acute stroke. , 2007, Archives of physical medicine and rehabilitation.

[258]  C. Braun,et al.  Motor learning elicited by voluntary drive. , 2003, Brain : a journal of neurology.

[259]  Takanori Shibata,et al.  Psychophysiological effects by interaction with mental commit robot , 2001, Proceedings 2001 IEEE/RSJ International Conference on Intelligent Robots and Systems. Expanding the Societal Role of Robotics in the the Next Millennium (Cat. No.01CH37180).

[260]  John Kenneth Salisbury,et al.  A New Actuation Approach for Human Friendly Robot Design , 2004, Int. J. Robotics Res..

[261]  E. van Lunteren,et al.  Improvement of diaphragm and limb muscle isotonic contractile performance by K+ channel blockade , 2010, Journal of NeuroEngineering and Rehabilitation.

[262]  S. Rossignol,et al.  Recovery of locomotion after chronic spinalization in the adult cat , 1987, Brain Research.

[263]  R. Ekkelenkamp,et al.  Selective control of a subtask of walking in a robotic gait trainer(LOPES) , 2007, 2007 IEEE 10th International Conference on Rehabilitation Robotics.

[264]  L. Zollo,et al.  Robotic technologies and rehabilitation: new tools for upper-limb therapy and assessment in chronic stroke. , 2011, European journal of physical and rehabilitation medicine.

[265]  Robert D. Lipschutz,et al.  Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study , 2007, The Lancet.

[266]  Elizabeth A. Croft,et al.  Validation of a Robotic Balance System for Investigations in the Control of Human Standing Balance , 2011, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[267]  G. Romani,et al.  Fundamentals of electroencefalography, magnetoencefalography, and functional magnetic resonance imaging. , 2009, International review of neurobiology.

[268]  Paolo Dario,et al.  MOVAID: a personal robot in everyday life of disabled and elderly people , 1999 .

[269]  Ichiro Sakuma,et al.  Development of a robot to assist patient transfer , 2004, 2004 IEEE International Conference on Systems, Man and Cybernetics (IEEE Cat. No.04CH37583).

[270]  H.F.M. Van der Loos,et al.  VA/Stanford rehabilitation robotics research and development program: lessons learned in the application of robotics technology to the field of rehabilitation , 1995 .

[271]  Hermano I Krebs,et al.  Telerehabilitation robotics: bright lights, big future? , 2006, Journal of rehabilitation research and development.

[272]  V. Dietz,et al.  Driven gait orthosis to do locomotor training of paraplegic patients , 2000, Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143).

[273]  Andrew B Schwartz,et al.  Cortical neural prosthetics. , 2004, Annual review of neuroscience.

[274]  Cordula Werner,et al.  Robot-assisted practice of gait and stair climbing in nonambulatory stroke patients. , 2012, Journal of rehabilitation research and development.

[275]  Toshiyuki Kondo,et al.  MR compatible manipulandum with ultrasonic motor for fMRI studies , 2006, Proceedings 2006 IEEE International Conference on Robotics and Automation, 2006. ICRA 2006..

[276]  A. Wernig,et al.  Maintenance of locomotor abilities following Laufband (treadmill) therapy in para- and tetraplegic persons: follow-up studies , 1998, Spinal Cord.

[277]  S. Adamovich,et al.  Sensorimotor Training in a Virtual Reality Environment: Does It Improve Functional Recovery Poststroke? , 2006, Neurorehabilitation and neural repair.

[278]  P. Feys,et al.  The Armeo Spring as training tool to improve upper limb functionality in multiple sclerosis: a pilot study , 2011, Journal of NeuroEngineering and Rehabilitation.

[279]  J. Mehrholz,et al.  Improved walking ability and reduced therapeutic stress with an electromechanical gait device. , 2009, Journal of rehabilitation medicine.

[280]  H.I. Krebs,et al.  Whole-Arm Rehabilitation Following Stroke: Hand Module , 2006, The First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006. BioRob 2006..