A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Citation for published version (APA): Nikpay, M., Goel, A., Won, H-H., Hall, L. M., Willenborg, C., Kanoni, S., Saleheen, D., Kyriakou, T., Nelson, C. P., Hopewell, J. C., Webb, T. R., Zeng, L., Dehghan, A., Elver, M., Armasu, S. M., Auro, K., Bjonnes, A., Chasman, D. I., Chen, S., ... Farrall, M. (2015). A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nature Genetics, 47(10), 1121-1130. https://doi.org/10.1038/ng.3396

[1]  David M. Herrington,et al.  Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction , 2014, Nature.

[2]  He Zhang,et al.  Loss-of-function mutations in APOC3, triglycerides, and coronary disease. , 2014, The New England journal of medicine.

[3]  R. Andrews,et al.  Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression , 2014, Science.

[4]  Jennifer G. Robinson,et al.  Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. , 2014, American journal of human genetics.

[5]  Pankaj Sharma,et al.  Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants , 2014, Stroke.

[6]  Peggy Hall,et al.  The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..

[7]  M. Nöthen,et al.  Dysfunctional nitric oxide signalling increases risk of myocardial infarction , 2013, Nature.

[8]  D. Barford,et al.  KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation , 2013, Cell.

[9]  Tanya M. Teslovich,et al.  Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.

[10]  M. Peters,et al.  Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.

[11]  R. Jessberger,et al.  The Switch-associated Protein 70 (SWAP-70) Bundles Actin Filaments and Contributes to the Regulation of F-actin Dynamics* , 2013, The Journal of Biological Chemistry.

[12]  Liming Liang,et al.  A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines , 2013, Genome research.

[13]  Andreas Ziegler,et al.  Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes , 2013, PLoS genetics.

[14]  J. Danesh,et al.  Large-scale association analysis identifies new risk loci for coronary artery disease , 2013 .

[15]  David C. Nickle,et al.  Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma , 2012, PLoS genetics.

[16]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[17]  Shane J. Neph,et al.  Systematic Localization of Common Disease-Associated Variation in Regulatory DNA , 2012, Science.

[18]  Simon C. Potter,et al.  Mapping cis- and trans-regulatory effects across multiple tissues in twins , 2012, Nature Genetics.

[19]  Tanya M. Teslovich,et al.  Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways , 2012, Nature Genetics.

[20]  Tanya M. Teslovich,et al.  The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits , 2012, PLoS genetics.

[21]  Tanya M. Teslovich,et al.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.

[22]  J. Marchini,et al.  Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.

[23]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[24]  Nilesh J Samani,et al.  A Genome-Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex , 2012, Circulation. Cardiovascular genetics.

[25]  K. VijayRaghavan,et al.  Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. , 2012, Experimental cell research.

[26]  C. Hoggart,et al.  Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase , 2012, Hypertension.

[27]  E. Nabel,et al.  Genomics of cardiovascular disease. , 2011, The New England journal of medicine.

[28]  Christian Gieger,et al.  Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure , 2011, Nature Genetics.

[29]  Tom R. Gaunt,et al.  Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk , 2011, Nature.

[30]  A. Matsuda,et al.  Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation , 2011, Apoptosis.

[31]  Simon C. Potter,et al.  Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease , 2011, PLoS genetics.

[32]  Jingyuan Fu,et al.  Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA , 2011, PLoS genetics.

[33]  P. Sham,et al.  Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases , 2011, Genetic epidemiology.

[34]  Mark I McCarthy,et al.  Genomic inflation factors under polygenic inheritance , 2011, European Journal of Human Genetics.

[35]  N. Mehta.  Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. , 2011, Circulation. Cardiovascular genetics.

[36]  P. Libby,et al.  Progress and challenges in translating the biology of atherosclerosis , 2011, Nature.

[37]  Qing Yang,et al.  Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population , 2011, Nature Genetics.

[38]  T. Assimes,et al.  Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies , 2011, The Lancet.

[39]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[40]  Muhammad Ashraf,et al.  Skeletal myoblasts for cardiac repair. , 2010, Regenerative medicine.

[41]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.

[42]  Ayellet V. Segrè,et al.  Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.

[43]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[44]  Børge G Nordestgaard,et al.  PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses. , 2010, Journal of the American College of Cardiology.

[45]  Reedik Mägi,et al.  GWAMA: software for genome-wide association meta-analysis , 2010, BMC Bioinformatics.

[46]  Silke Szymczak,et al.  Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility , 2010, PloS one.

[47]  Luigi Ferrucci,et al.  Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain , 2010, PLoS genetics.

[48]  David B. Goldstein,et al.  Rare Variants Create Synthetic Genome-Wide Associations , 2010, PLoS biology.

[49]  R. Collins,et al.  Genetic variants associated with Lp(a) lipoprotein level and coronary disease. , 2009, The New England journal of medicine.

[50]  K. Frazer,et al.  Common vs. rare allele hypotheses for complex diseases. , 2009, Current opinion in genetics & development.

[51]  Huilin Zhou,et al.  hNOA1 Interacts with Complex I and DAP3 and Regulates Mitochondrial Respiration and Apoptosis* , 2009, Journal of Biological Chemistry.

[52]  Mark I. McCarthy,et al.  Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies , 2008, PloS one.

[53]  S. Kathiresan.  A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. , 2008, The New England journal of medicine.

[54]  K. Yamamura,et al.  Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. , 2008, Biochemical and biophysical research communications.

[55]  J. Danesh,et al.  Association of apolipoprotein E genotypes with lipid levels and coronary risk. , 2007, JAMA.

[56]  C. Gieger,et al.  Genomewide association analysis of coronary artery disease. , 2007, The New England journal of medicine.

[57]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[58]  J. Hirschhorn,et al.  Genetic model testing and statistical power in population‐based association studies of quantitative traits , 2007, Genetic epidemiology.

[59]  Juan P Casas,et al.  Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. , 2006, American journal of epidemiology.

[60]  AlexBobik.  Transforming Growth Factor-βs and Vascular Disorders , 2006 .

[61]  Jonathan C. Cohen,et al.  Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. , 2006, The New England journal of medicine.

[62]  A. Cheong,et al.  Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. , 2005, Molecular cell.

[63]  B. A. French,et al.  Infarct-Sparing Effect of A2A-Adenosine Receptor Activation Is Due Primarily to Its Action on Lymphocytes , 2005, Circulation.

[64]  Sebastian Amigorena,et al.  Lactadherin promotes VEGF-dependent neovascularization , 2005, Nature Medicine.

[65]  T. Suda,et al.  Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the α/β hydrolase domain containing 2 gene , 2005 .

[66]  K. Suk,et al.  BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1α , 2004, The Journal of experimental medicine.

[67]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[68]  Keiko Miwa,et al.  Identification of a factor that links apoptotic cells to phagocytes , 2002, Nature.

[69]  ZiadMallat,et al.  Inhibition of Transforming Growth Factor-β Signaling Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Mice , 2001 .

[70]  Y. Benjamini,et al.  THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .

[71]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[72]  Anita B. Roberts,et al.  Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response , 1999, Nature Cell Biology.

[73]  Gail Mandel,et al.  REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons , 1995, Cell.

[74]  R. Jackson,et al.  Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CoA reductase gene expression in a human hepatoma cell line, HepG2. , 1990, The Journal of biological chemistry.

[75]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[76]  W. G. Cochran.  The combination of estimates from different experiments. , 1954 .

[77]  Inactivating Mutations in NPC 1 L 1 and Protection from Coronary Heart Disease , 2014 .

[78]  J. Erdmann,et al.  Genetics of Coronary Artery Disease and Myocardial Infarction - 2013 , 2013, Current Cardiology Reports.

[79]  Avner Schlessinger,et al.  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , 2012 .

[80]  R. Newson.  Frequentist q–values for multiple–test procedures , 2010 .

[81]  Tanya M. Teslovich,et al.  Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .

[82]  Yali Zhang,et al.  Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis , 2006, Stem Cell Reviews.