An Economical Access to 3,4‐Diaryl‐2(5H)‐furanones and 4‐Aryl‐6‐methyl‐2(2H)‐pyranones by Pd‐Catalyzed Suzuki‐Type Arylation of 3‐Aryl‐4‐tosyloxy‐2(5H)‐furanones and 6‐Methyl‐4‐tosyloxy‐2(2H)‐pyranones, Respectively

Both symmetrical and unsymmetrical 3,4-diaryl-substituted 2(5H)-furanones have been efficiently synthesized using an inexpensive procedure involving the Pd(OAc)2/PCy3-catalyzed Suzuki-type arylation of readily available 3-aryl-4-tosyloxy-2(5H)-furanones as the key step. The mild conditions of this arylation protocol have also been used for the high yielding synthesis of 4-aryl-6-methyl-2(2H)-pyranones from 6-methyl-4-tosyloxy-2(2H)-pyranone. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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