Taste and weight: is there a link?

Investigations of the relations between taste perception and obesity have concentrated largely on sweet and bitter tastes, with little work on the "savory" tastes-salt and glutamate-and very little work on sour taste. This article briefly reviews current understanding of the relations between the ability to taste different tastes (ie, taste threshold for sweet, bitter, sour, salt, and umami) and body mass. Obese children and adolescents show a disturbance in some tastes, with reported reductions in sweet and salt thresholds. Observations on relations between sweet taste threshold and obesity are contradictory; literature discrepancies may depend on the techniques used to evaluate taste. Obese women, however, report higher intensities of monosodium glutamate perception. Taste thresholds have been reported to be raised (bitter and sour), lowered (salt), or unchanged (sweet) in obese adults. Taste perceptual changes (threshold, intensity) in obesity are complex and may be different in obese men and women and in adults and children. Very little is currently known about the relations between savory tastes-salt and umami-and body weight, and these areas merit further study.

[1]  C. Maffeis,et al.  Could the Savory Taste of Snacks Be a Further Risk Factor for Overweight in Children? , 2008, Journal of pediatric gastroenterology and nutrition.

[2]  B. Simmen,et al.  Taste perception in massively obese and in non-obese adolescents. , 2007, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

[3]  Xiaodong Li T1R receptors mediate mammalian sweet and umami taste. , 2009, The American journal of clinical nutrition.

[4]  J. Kaunitz,et al.  Luminal chemosensing and upper gastrointestinal mucosal defenses. , 2009, The American journal of clinical nutrition.

[5]  L. Bartoshuk,et al.  Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. , 2000, Chemical senses.

[6]  C. Sano History of glutamate production. , 2009, The American journal of clinical nutrition.

[7]  R. Hawkins,et al.  The blood-brain barrier and glutamate. , 2009, The American journal of clinical nutrition.

[8]  Pierre J Magistretti,et al.  Role of glutamate in neuron-glia metabolic coupling. , 2009, The American journal of clinical nutrition.

[9]  Derek J Snyder,et al.  Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[10]  A. Obrębowski,et al.  Smell and taste in children with simple obesity. , 2000, International journal of pediatric otorhinolaryngology.

[11]  Y. Ninomiya,et al.  Variation in umami perception and in candidate genes for the umami receptor in mice and humans. , 2009, The American journal of clinical nutrition.

[12]  B. Tepper,et al.  Sweet taste and intake of sweet foods in normal pregnancy and pregnancy complicated by gestational diabetes mellitus. , 1999, The American journal of clinical nutrition.

[13]  A. Drewnowski,et al.  Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. , 2007, Journal of the American Dietetic Association.

[14]  Y. Ninomiya,et al.  Multiple receptors underlie glutamate taste responses in mice. , 2009, The American journal of clinical nutrition.

[15]  M. Inoue,et al.  Glutamate taste and appetite in laboratory mice: physiologic and genetic analyses. , 2009, The American journal of clinical nutrition.

[16]  K. Kurihara Glutamate: from discovery as a food flavor to role as a basic taste (umami). , 2009, The American journal of clinical nutrition.

[17]  Tom R. Gaunt,et al.  TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. , 2005, The American journal of clinical nutrition.

[18]  B. Tepper,et al.  Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. , 2005, Obesity research.

[19]  R. Margolskee,et al.  Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. , 2009, The American journal of clinical nutrition.

[20]  J. Melichar,et al.  Human Taste Thresholds Are Modulated by Serotonin and Noradrenaline , 2006, The Journal of Neuroscience.

[21]  T. Spector,et al.  The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations. , 2008, The American journal of clinical nutrition.

[22]  S. Schiffman,et al.  Elevated and sustained desire for sweet taste in african-americans: a potential factor in the development of obesity. , 2000, Nutrition.

[23]  R. I. Curtis Umami and the foods of classical antiquity. , 2009, The American journal of clinical nutrition.

[24]  M. Brosnan,et al.  Hepatic glutamate metabolism: a tale of 2 hepatocytes. , 2009, The American journal of clinical nutrition.

[25]  J. Lumeng,et al.  Ability to Taste 6‐n‐Propylthiouracil and BMI in Low‐income Preschool‐aged Children , 2008, Obesity.

[26]  G. Beauchamp,et al.  Early milk feeding influences taste acceptance and liking during infancy. , 2009, The American journal of clinical nutrition.

[27]  Adam Drewnowski,et al.  Taste preferences and body weight changes in an obesity-prone population. , 2004, The American journal of clinical nutrition.

[28]  J. Fernstrom Symposium summary. The roles of glutamate in taste, gastrointestinal function, metabolism, and physiology. , 2009, The American journal of clinical nutrition.

[29]  Edmund T Rolls,et al.  Functional neuroimaging of umami taste: what makes umami pleasant? , 2009, The American journal of clinical nutrition.

[30]  Adam Drewnowski,et al.  Sweet tooth reconsidered: Taste responsiveness in human obesity , 1985, Physiology & Behavior.

[31]  A. Drewnowski,et al.  Obesity and flavor perception: Multidimensional scaling of soft drinks , 1982, Appetite.

[32]  B. Tepper,et al.  Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children , 2002, Appetite.

[33]  D. Tomé,et al.  Protein, amino acids, vagus nerve signaling, and the brain. , 2009, The American journal of clinical nutrition.

[34]  P. Breslin,et al.  Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. , 2009, The American journal of clinical nutrition.

[35]  B. Tepper,et al.  Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women , 2002, Physiology & Behavior.

[36]  S. Kinnamon Umami taste transduction mechanisms. , 2009, The American journal of clinical nutrition.

[37]  J. Guinard,et al.  Relation between PROP (6-n-propylthiouracil) taster status, taste anatomy and dietary intake measures for young men and women , 2002, Appetite.

[38]  J. Grinker Obesity and sweet taste. , 1978, The American journal of clinical nutrition.

[39]  P. Gasparini,et al.  Variation in the Bitter‐taste Receptor Gene TAS2R38, and Adiposity in a Genetically Isolated Population in Southern Italy , 2008, Obesity.

[40]  M. Westerterp-Plantenga,et al.  Taste sensitivity for monosodium glutamate and an increased liking of dietary protein , 2008, British Journal of Nutrition.

[41]  G. Anderson Sugars, sweetness, and food intake. , 1995, The American journal of clinical nutrition.

[42]  B. Simmen,et al.  Taste acuity of obese adolescents and changes in food neophobia and food preferences during a weight reduction session , 2008, Appetite.

[43]  H. Uneyama,et al.  Can dietary supplementation of monosodium glutamate improve the health of the elderly? , 2009, The American journal of clinical nutrition.

[44]  J. Fernstrom Introduction to the symposium. The roles of glutamate in taste, gastrointestinal function, metabolism, and physiology. , 2009, The American journal of clinical nutrition.

[45]  A. Drewnowski,et al.  Taste preferences and food intake. , 1997, Annual review of nutrition.

[46]  J. Finsterer,et al.  Loss of taste is loss of weight , 2002, The Lancet.

[47]  B. Stoll,et al.  Metabolic fate and function of dietary glutamate in the gut. , 2009, The American journal of clinical nutrition.

[48]  P. O'Neil,et al.  Taste hedonics and thresholds in obesity. , 1980, International journal of obesity.

[49]  J. Frijters,et al.  Sensory discrimination, intensity perception, and affective judgment of sucrose-sweetness in the overweight. , 1982, The Journal of general psychology.

[50]  C. Stanley Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children. , 2009, The American journal of clinical nutrition.

[51]  A. Drewnowski,et al.  Cream and sugar: Human preferences for high-fat foods , 1983, Physiology & Behavior.

[52]  B. Tepper Does Genetic Taste Sensitivity to PROP Influence Food Preferences and Body Weight? , 1999, Appetite.

[53]  L. Bartoshuk,et al.  The psychophysics of taste. , 1978, The American journal of clinical nutrition.

[54]  G. Beauchamp Sensory and receptor responses to umami: an overview of pioneering work. , 2009, The American journal of clinical nutrition.

[55]  Gordon H. Sellon Symposium Summary , 2022 .

[56]  A. Faurion,et al.  Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate. , 2009, The American journal of clinical nutrition.

[57]  K. Torii,et al.  Metabotropic glutamate receptor type 1 in taste tissue 1 – 3 , 2009 .

[58]  J. Krebs,et al.  The gourmet ape: evolution and human food preferences. , 2009, The American journal of clinical nutrition.

[59]  C L Rock,et al.  The influence of genetic taste markers on food acceptance. , 1995, The American journal of clinical nutrition.

[60]  D. Reed,et al.  Genetic and Environmental Determinants of Bitter Perception and Sweet Preferences , 2005, Pediatrics.

[61]  B. Tepper,et al.  Influence of PROP taster status and maternal variables on energy intake and body weight of pre-adolescents , 2007, Physiology & Behavior.

[62]  N. Chaudhari,et al.  Taste receptors for umami: the case for multiple receptors. , 2009, The American journal of clinical nutrition.

[63]  A. Drewnowski,et al.  Young women's food preferences and taste responsiveness to 6-n-propylthiouracil (PROP) , 2000, Physiology & Behavior.

[64]  C. Koebnick,et al.  Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight , 2006, European Journal of Clinical Nutrition.

[65]  H. Mallick,et al.  Activation of the gut-brain axis by dietary glutamate and physiologic significance in energy homeostasis. , 2009, The American journal of clinical nutrition.

[66]  B. Tepper,et al.  Inherited taste sensitivity to 6-n-propylthiouracil in diet and body weight in children. , 2004, Obesity research.

[67]  L Perry,et al.  Sensory and hedonic associations with macronutrient and energy intakes of lean and obese consumers , 1999, International Journal of Obesity.

[68]  D. Tomé,et al.  Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines. , 2009, The American journal of clinical nutrition.