Characteristics and function of the UL34 gene and its encoding protein in herpesvirus

The herpesvirus UL34 gene is highly conserved in the Herpesviridae family. The nucleotide sequence has the characteristic of comparatively high content of G + C and the gene product is a tail-anchored type II membrane protein involved in the primary envelopment of capsid in the endoplasmic reticulum, profiting the virion maturation and nucleocapsid budding, regulating the proper location of the UL31 protein and lamin in infected cells. In this work, we summarize the research progress on characteristic and function of the UL34 gene and its encoding protein to provide some new insights into the molecular biology of herpesvirus and its mechanism of replication.

[1]  Thomas Forest,et al.  US3 of Herpes Simplex Virus Type 1 Encodes a Promiscuous Protein Kinase That Phosphorylates and Alters Localization of Lamin A/C in Infected Cells , 2007, Journal of Virology.

[2]  S. Finke,et al.  Vesicle formation from the nuclear membrane is induced by coexpression of two conserved herpesvirus proteins , 2007, Proceedings of the National Academy of Sciences.

[3]  C. Mannella,et al.  Electron Tomography of Nascent Herpes Simplex Virus Virions , 2007, Journal of Virology.

[4]  U. Koszinowski,et al.  Common and Specific Properties of Herpesvirus UL34/UL31 Protein Family Members Revealed by Protein ComplementationAssay , 2006, Journal of Virology.

[5]  R. Roller,et al.  Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress. , 2006, Virology.

[6]  T. Mettenleiter,et al.  Egress of Alphaherpesviruses , 2006, Journal of Virology.

[7]  U. Koszinowski,et al.  Functional Domains of Murine Cytomegalovirus Nuclear Egress Protein M53/p38 , 2006, Journal of Virology.

[8]  Cheng An-chun.  Studies on Morphogenesis of Duck Enteritis Virus CH Virulent Isolate in Infected Duck Embryo Fibroblasts , 2006 .

[9]  J. Baines,et al.  Identification of an Essential Domain in the Herpes Simplex Virus 1 UL34 Protein That Is Necessary and Sufficient To Interact with UL31 Protein , 2005, Journal of Virology.

[10]  T. Mettenleiter.  Budding events in herpesvirus morphogenesis. , 2004, Virus research.

[11]  Y. Kawaguchi,et al.  Cell lines that support replication of a novel herpes simplex virus 1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31. , 2004, Virology.

[12]  B. Biegalke,et al.  Characterization of the Human Cytomegalovirus UL34 Gene , 2004, Journal of Virology.

[13]  U. Koszinowski,et al.  Comprehensive Mutational Analysis of a Herpesvirus Gene in the Viral Genome Context Reveals a Region Essential for Virus Replication , 2004, Journal of Virology.

[14]  K. Byth,et al.  Herpes Simplex Virus Type 1 Capsid Protein VP26 Interacts with Dynein Light Chains RP3 and Tctex1 and Plays a Role in Retrograde Cellular Transport* , 2004, Journal of Biological Chemistry.

[15]  D. Knipe,et al.  Herpes Simplex Virus 1 UL31 and UL34 Gene Products Promote the Late Maturation of Viral Replication Compartments to the Nuclear Periphery , 2004, Journal of Virology.

[16]  J. Baines,et al.  Conformational Changes in the Nuclear Lamina Induced by Herpes Simplex Virus Type 1 Require Genes UL31 and UL34 , 2004, Journal of Virology.

[17]  Brent J. Ryckman,et al.  Herpes Simplex Virus Type 1 Primary Envelopment: UL34 Protein Modification and the US3-UL34 Catalytic Relationship , 2004, Journal of Virology.

[18]  Y. Nishiyama.  Herpes simplex virus gene products: the accessories reflect her lifestyle well , 2004, Reviews in medical virology.

[19]  R. Roller,et al.  Effects of Charged Cluster Mutations on the Function of Herpes Simplex Virus Type 1 UL34 Protein , 2003, Journal of Virology.

[20]  Brent J. Ryckman,et al.  Ultrastructural Localization of the Herpes Simplex Virus Type 1 UL31, UL34, and US3 Proteins Suggests Specific Roles in Primary Envelopment and Egress of Nucleocapsids , 2002, Journal of Virology.

[21]  T. Mettenleiter.  Herpesvirus Assembly and Egress , 2002, Journal of Virology.

[22]  B. Klupp,et al.  The Interacting UL31 and UL34 Gene Products of Pseudorabies Virus Are Involved in Egress from the Host-Cell Nucleus and Represent Components of Primary Enveloped but Not Mature Virions , 2002, Journal of Virology.

[23]  Brent J. Ryckman,et al.  UL31 and UL34 Proteins of Herpes Simplex Virus Type 1 Form a Complex That Accumulates at the Nuclear Rim and Is Required for Envelopment of Nucleocapsids , 2001, Journal of Virology.

[24]  Y. Yamauchi,et al.  Herpes simplex virus type 2 UL34 protein requires UL31 protein for its relocation to the internal nuclear membrane in transfected cells. , 2001, The Journal of general virology.

[25]  Chen Huan-chun.  Cloning and Sequence Analysis of the Us9 Gene of Pseudorabies Virus Ea Strain , 2001 .

[26]  B. Klupp,et al.  Primary Envelopment of Pseudorabies Virus at the Nuclear Membrane Requires the UL34 Gene Product , 2000, Journal of Virology.

[27]  Y. Yamauchi,et al.  The UL34 gene product of herpes simplex virus type 2 is a tail-anchored type II membrane protein that is significant for virus envelopment. , 2000, The Journal of general virology.

[28]  R. Vallee,et al.  The Herpes Simplex Virus 1 UL34 Protein Interacts with a Cytoplasmic Dynein Intermediate Chain and Targets Nuclear Membrane , 2000, Journal of Virology.

[29]  R. Roller,et al.  Herpes Simplex Virus Type 1 UL34 Gene Product Is Required for Viral Envelopment , 2000, Journal of Virology.

[30]  C. Van Sant,et al.  The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[31]  B. Roizman,et al.  UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins , 1992, Journal of virology.

[32]  B. Roizman,et al.  The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene , 1991, Journal of virology.

[33]  L. J. Perry,et al.  The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. , 1988, The Journal of general virology.

[34]  Y. Nishizuka,et al.  Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. , 1985, The Journal of biological chemistry.