Non-invasive estimation of thermal tissue properties by high-intensity focused ultrasound

Magnetic Resonance guided High-intensity Focused Ultrasound (MR-HIFU) can be used to locally heat tissue while non-invasively monitoring tissue temperature via MR-based thermometry. The goal of this study was to investigate the use of a computational technique based on inverse heat-transfer modeling for the non-invasive measurement of thermal tissue properties from data collected using an MR-HIFU system.

[1]  H. Arkin,et al.  Recent developments in modeling heat transfer in blood perfused tissues , 1994, IEEE Transactions on Biomedical Engineering.

[2]  Bruno Quesson,et al.  Non‐invasive determination of tissue thermal parameters from high intensity focused ultrasound treatment monitored by volumetric MRI thermometry , 2009, NMR in biomedicine.

[3]  Kim Butts Pauly,et al.  MR thermometry , 2008, Journal of magnetic resonance imaging : JMRI.

[4]  Raja Muthupillai,et al.  Volumetric MRI‐guided high‐intensity focused ultrasound for noninvasive, in vivo determination of tissue thermal conductivity: Initial experience in a pig model , 2013, Journal of magnetic resonance imaging : JMRI.

[5]  David L. Woods,et al.  Mild hyperthermia with magnetic resonance-guided high-intensity focused ultrasound for applications in drug delivery , 2012, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[6]  R C Eberhart,et al.  THERMAL DILUTION METHODS: ESTIMATION OF TISSUE BLOOD FLOW AND METABOLISM * , 1980, Annals of the New York Academy of Sciences.

[7]  H. H. Penns Analysis of tissue and arterial blood temperatures in the resting human forearm , 1948 .

[8]  Jun Aoki,et al.  Quantitative perfusion map of malignant liver tumors, created from dynamic computed tomography data. , 2004, Academic radiology.

[9]  P Hofman,et al.  Perfusion analyses in advanced breast carcinoma during hyperthermia. , 1988, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[10]  K. Kuroda,et al.  A precise and fast temperature mapping using water proton chemical shift , 1995, Magnetic resonance in medicine.

[11]  David L. Woods,et al.  Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes : Computational modelling and preliminary in vivo validation , 2012 .

[12]  Charles Mougenot,et al.  Feasibility of Agar‐Silica Phantoms in Quality Assurance of MRgHIFU , 2009 .

[13]  K. Hynynen,et al.  MRI-Controlled Ultrasound Thermal Therapy , 2011, IEEE Pulse.

[14]  Azeem Saleem,et al.  Early Tumor Drug Pharmacokinetics Is Influenced by Tumor Perfusion but not Plasma Drug Exposure , 2008, Clinical Cancer Research.

[15]  Ashish Ranjan,et al.  Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Frank Rattay,et al.  Mathematical spatio-temporal model of drug delivery from low temperature sensitive liposomes during radiofrequency tumour ablation , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[17]  Kim Butts Pauly,et al.  Echo combination to reduce proton resonance frequency (PRF) thermometry errors from fat , 2008, Journal of magnetic resonance imaging : JMRI.