论文信息 - r-2,c-6-Bis(4-chlorophenyl)-c-3,t-3-dimethylpiperidin-4-one

r-2,c-6-Bis(4-chlorophenyl)-c-3,t-3-dimethylpiperidin-4-one

In the title molecule, C19H19Cl2NO, the piperidine ring adopts a chair conformation and the dihedral angle between the two benzene rings is 77.23 (7)°. In the crystal structure, molecules are linked by N—H⋯O and C—H⋯O hydrogen bonds, and a weak C—H⋯π interaction is also observed.

[1] G. G. Stokes. "J." , 1890, The New Yale Book of Quotations.

[2] 良二上田. J. Appl. Cryst.の発刊に際して , 1970 .

[3] G. Sheldrick. A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[4] P. Gayathri,et al. r-2,c-6-Bis(4-chlorophenyl)-t-3-isopropyl-1-nitrosopiperidin-4-one , 2008, Acta crystallographica. Section E, Structure reports online.

[5] C. Noller,et al. The preparation of some piperidine derivatives by the Mannich reaction. , 1948, Journal of the American Chemical Society.

[6] Anthony L. Spek,et al. Journal of , 1993 .

[7] M. N. Ponnuswamy,et al. Fast N-CO rotational equilibria in twist-boat conformations of N -ethoxycarbonyl- r- 2 , c -6-diphenylpiperidin-4-ones and N -ethoxycarbonyl- r -2, c -6-diphenylpiperidines , 2002 .

[8] E. De Clercq,et al. A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues. , 2001, Journal of medicinal chemistry.

[9] Louis J. Farrugia,et al. ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) , 1997 .

[10] H. Flack,et al. On enantiomorph‐polarity estimation , 1983 .