Association of Age With SARS-CoV-2 Antibody Response

Key Points Question Are the quantity and quality of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) different among children, adolescents, and young adults? Findings In this cross-sectional study evaluating 31 426 SARS-CoV-2 antibody tests performed between April 9 and August 31, 2020, immunoglobin G levels were found to vary in different age groups, despite similar seroprevalence in the pediatric and adult patient populations. SARS-CoV-2 immunoglobin G and total antibody levels, neutralizing activity, and avidity exhibited negative correlations with age in patients aged 1 to 24 years. Meaning This analysis revealed distinct antibody responses in different age groups, suggesting that age-targeted strategies for disease screening and management as well as vaccine development may be warranted.

[1]  M. Nussenzweig,et al.  TOP-Plus is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability , 2021, medRxiv.

[2]  John P. Moore,et al.  Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health , 2021, The Journal of clinical endocrinology and metabolism.

[3]  John P. Moore,et al.  Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients , 2021, Biosensors and Bioelectronics.

[4]  G. Malerba,et al.  Cross-Immunization Against Respiratory Coronaviruses May Protect Children From SARS-CoV2: More Than a Simple Hypothesis? , 2021, Frontiers in Pediatrics.

[5]  E. Hod,et al.  Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum , 2020, Nature Immunology.

[6]  J. Tate,et al.  Symptoms and Transmission of SARS-CoV-2 Among Children — Utah and Wisconsin, March–May 2020 , 2020, Pediatrics.

[7]  Sandy F. Price,et al.  COVID-19 Trends Among School-Aged Children — United States, March 1–September 19, 2020 , 2020, MMWR. Morbidity and mortality weekly report.

[8]  K. Lynch,et al.  Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity , 2020, Clinical Infectious Diseases.

[9]  S. Elahi.  Neonatal and Children’s Immune System and COVID-19: Biased Immune Tolerance versus Resistance Strategy , 2020, The Journal of Immunology.

[10]  Simon Li,et al.  Multisystem Inflammatory Syndrome in U.S. Children and Adolescents , 2020, The New England journal of medicine.

[11]  M. Noverr,et al.  Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection? , 2020, mBio.

[12]  P. Davies,et al.  Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. , 2020, JAMA.

[13]  M. Loda,et al.  SARS-CoV-2 antibody characterization in emergency department, hospitalized and convalescent patients by two semi-quantitative immunoassays , 2020, Clinica Chimica Acta.

[14]  R. Lodha,et al.  Pathophysiology of COVID-19: Why Children Fare Better than Adults? , 2020, Indian journal of pediatrics.

[15]  F. Rovida,et al.  Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. , 2020, JAMA pediatrics.

[16]  J. Ludvigsson.  Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults , 2020, Acta paediatrica.

[17]  Zhongyi Jiang,et al.  Epidemiology of COVID-19 Among Children in China , 2020, Pediatrics.

[18]  N. Curtis,et al.  Coronavirus Infections in Children Including COVID-19 , 2020, The Pediatric infectious disease journal.

[19]  Zhongyi Jiang,et al.  Epidemiology of COVID-19 Among Children in China , 2020, Pediatrics.

[20]  Yhu-Chering Huang,et al.  Are children less susceptible to COVID-19? , 2020, Journal of Microbiology, Immunology and Infection.

[21]  Zunyou Wu,et al.  Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. , 2020, JAMA.

[22]  F. Gudé,et al.  Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities , 2007, Clinical and experimental immunology.

[23]  C. E..  WHO Coronavirus Disease (COVID-19) Dashboard , 2020 .