A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity

[1]  R. Spang,et al.  T cells become licensed in the lung to enter the central nervous system , 2012, Nature.

[2]  Susana Gordo,et al.  Self-reactive human CD4 T cell clones form unusual immunological synapses , 2012, The Journal of experimental medicine.

[3]  Michael Loran Dustin,et al.  Migration of cytotoxic lymphocytes in cell cycle permits local MHC I–dependent control of division at sites of viral infection , 2011, The Journal of experimental medicine.

[4]  S. Miller,et al.  The role of antigen presenting cells in multiple sclerosis. , 2011, Biochimica et biophysica acta.

[5]  Andrew L Croxford,et al.  Cytokine reporter mice in immunological research: perspectives and lessons learned , 2011, Immunology.

[6]  D. Parker,et al.  Diversity in immunological synapse structure , 2010, Immunology.

[7]  Matthew F. Krummel,et al.  Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics , 2010, The Journal of experimental medicine.

[8]  Philippe Bousso,et al.  Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes , 2010, Proceedings of the National Academy of Sciences.

[9]  H. Wekerle,et al.  Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions , 2009, Nature.

[10]  R. Ransohoff,et al.  Localizing central nervous system immune surveillance: Meningeal antigen‐presenting cells activate T cells during experimental autoimmune encephalomyelitis , 2009, Annals of neurology.

[11]  Michael L. Dustin,et al.  MYELOMONOCYTIC CELL RECRUITMENT CAUSES FATAL CNS VASCULAR INJURY DURING ACUTE VIRAL MENINGITIS , 2008, Nature.

[12]  Rudolf Jaenisch,et al.  Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells , 2009, Nature Biotechnology.

[13]  P. Miccoli,et al.  Perspectives and Lessons Learned after a Decade of Minimally Invasive Video-Assisted Thyroidectomy , 2008, ORL.

[14]  Ian Parker,et al.  Choreography of Cell Motility and Interaction Dynamics Imaged by Two-photon Microscopy in Lymphoid Organs , 2007 .

[15]  Rajat Varma,et al.  Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes , 2007, Nature Immunology.

[16]  H. Lassmann,et al.  Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis , 2007, Proceedings of the National Academy of Sciences.

[17]  Y. Imai,et al.  Visualization of microglia in living tissues using Iba1‐EGFP transgenic mice , 2005, Journal of neuroscience research.

[18]  S. Miller,et al.  Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis , 2005, Nature Medicine.

[19]  B. Becher,et al.  Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis , 2005, Nature Medicine.

[20]  B. Becher,et al.  Experimental autoimmune encephalomyelitis repressed by microglial paralysis , 2005, Nature Medicine.

[21]  Sebastian Amigorena,et al.  Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity , 2004, Nature Immunology.

[22]  D. Brenner,et al.  In Vivo Pattern of Lipopolysaccharide and Anti-CD3-Induced NF-κB Activation Using a Novel Gene-Targeted Enhanced GFP Reporter Gene Mouse1 , 2004, The Journal of Immunology.

[23]  R. Ransohoff,et al.  The Activation Status of Neuroantigen-specific T Cells in the Target Organ Determines the Clinical Outcome of Autoimmune Encephalomyelitis , 2004, The Journal of experimental medicine.

[24]  S. Henrickson,et al.  T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases , 2004, Nature.

[25]  H. Wiśniewski,et al.  Chronic relapsing EAE time course of neurological symptoms and pathology , 1978, Acta Neuropathologica.

[26]  Taichiro Tomida,et al.  NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation , 2003, The EMBO journal.

[27]  Boris Barbour,et al.  Functional antigen-independent synapses formed between T cells and dendritic cells , 2001, Nature Immunology.

[28]  Roland Martin,et al.  Dendritic cells signal T cells in the absence of exogenous antigen , 2001, Nature Immunology.

[29]  E. Bröcker,et al.  Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. , 2000, Immunity.

[30]  R. Hockett,et al.  Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function. , 1999, Immunity.

[31]  P. McMenamin,et al.  Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations , 1999, The Journal of comparative neurology.

[32]  K. Arai,et al.  Signalling into the T-cell nucleus: NFAT regulation. , 1998, Cellular signalling.

[33]  T. Kanda,et al.  Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells , 1998, Current Biology.

[34]  E. Price,et al.  Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 , 1996, Nature.

[35]  P. Hogan,et al.  T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1 , 1996, Molecular and cellular biology.

[36]  G. Crabtree,et al.  Identification of a putative regulator of early T cell activation genes. , 1988, Science.

[37]  F. Moolten Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. , 1986, Cancer research.