论文信息 - Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant - 字舞流文

Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant

N. Sach | H. Zou | R. Kania | M. Edwards | T. Smeal | A. Brooun | A. Stewart | S. Bailey | M. Collins | Ya-li Deng | J. Kath | B. Burke | Justine L. Lam | P. Richardson | D. Dinh | Hieu Lam | T. Johnson | R. Hoffman | Lars D. Engstrom | Mctigue | Graham L. Smith | Wei Liu | Huichun Zhu | J. Cui | J. Hoffman | Jinjiang Zhu | P. Le | Mingying He | Qinhua Huang | J. Deal | Laura Lingardo | C. Palmer | Sergei L. Timofeevski