Mechanisms of TNFα regulation in uveitis: Focus on RNA-binding proteins

[1]  D. Copland,et al.  TNFR1 signalling is a critical checkpoint for developing macrophages that control of T‐cell proliferation , 2010, Immunology.

[2]  T. Nork,et al.  Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105. , 2010, Investigative ophthalmology & visual science.

[3]  Ying Chen,et al.  The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. , 2010, Investigative ophthalmology & visual science.

[4]  A. Joussen,et al.  Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization. , 2010, Investigative ophthalmology & visual science.

[5]  Sylvain Foissac,et al.  New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism , 2010, Nature.

[6]  Peter Scheurich,et al.  Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2. , 2010, Cellular signalling.

[7]  A. Dick,et al.  Fragile X‐related protein FXR1 controls post‐transcriptional suppression of lipopolysaccharide‐induced tumour necrosis factor‐α production by transforming growth factor‐β1 , 2010, The FEBS journal.

[8]  A. Dick,et al.  Immune mechanisms of intraocular inflammation , 2010 .

[9]  A. Dick,et al.  Clinical Review: Anti-TNFα Therapies in Uveitis: Perspective on 5 Years of Clinical Experience , 2009, Ocular immunology and inflammation.

[10]  M. Boulton,et al.  Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. , 2009, The American journal of pathology.

[11]  J. Forrester,et al.  Para-inflammation in the aging retina , 2009, Progress in Retinal and Eye Research.

[12]  A. Dick,et al.  TNFR1-Dependent Regulation of Myeloid Cell Function in Experimental Autoimmune Uveoretinitis1 , 2009, The Journal of Immunology.

[13]  P. Blackshear,et al.  Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-101 , 2009, The Journal of Immunology.

[14]  J. Kempen,et al.  Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study , 2009, BMJ : British Medical Journal.

[15]  J. Karakaya,et al.  Inflammatory mediators and posterior segment involvement in ocular Behçet disease , 2009, European journal of ophthalmology.

[16]  P. Sfikakis,et al.  Intravitreal administration of the anti-tumor necrosis factor agent infliximab for neovascular age-related macular degeneration. , 2009, American journal of ophthalmology.

[17]  E. Sasso,et al.  Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor. , 2009, Clinical immunology.

[18]  B. Ryffel,et al.  Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. , 2009, The Journal of infectious diseases.

[19]  D. Baltimore,et al.  The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules , 2009, Nature Immunology.

[20]  A. El-Remessy,et al.  Diabetic Retinopathy: Current Management and Experimental Therapeutic Targets , 2009, Pharmacotherapy.

[21]  A. Dick,et al.  Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. , 2008, Journal of autoimmunity.

[22]  E. Agardh,et al.  TNF-alpha is an independent serum marker for proliferative retinopathy in type 1 diabetic patients. , 2008, Journal of diabetes and its complications.

[23]  B. Frey,et al.  A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. , 2008, Genome research.

[24]  G. Stoecklin,et al.  Control of mRNA decay by phosphorylation of tristetraprolin. , 2008, Biochemical Society transactions.

[25]  H. Saya,et al.  Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells , 2008, The EMBO journal.

[26]  Raphael Nudelman,et al.  Drug Insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis , 2008, Nature Clinical Practice Rheumatology.

[27]  A. Yoshimura,et al.  Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis , 2008 .

[28]  J. Bradley,et al.  TNF‐mediated inflammatory disease , 2008, The Journal of pathology.

[29]  D. Radzioch,et al.  Posttranscriptional gene expression regulation in CpG-activated macrophages depends on FXR1P RNA-binding protein. , 2007, FEMS immunology and medical microbiology.

[30]  A. Dick,et al.  Biologics in the treatment of uveitis , 2007, Current opinion in ophthalmology.

[31]  Muller Fabbri,et al.  Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock1 , 2007, The Journal of Immunology.

[32]  S. Yamasaki,et al.  T-cell Intracellular Antigen-1 (TIA-1)-induced Translational Silencing Promotes the Decay of Selected mRNAs* , 2007, Journal of Biological Chemistry.

[33]  M. Rossol,et al.  Interaction between Transmembrane TNF and TNFR1/2 Mediates the Activation of Monocytes by Contact with T Cells1 , 2007, The Journal of Immunology.

[34]  L. Sandell,et al.  Nuclear Protein TIA-1 Regulates COL2A1 Alternative Splicing and Interacts with Precursor mRNA and Genomic DNA* , 2007, Journal of Biological Chemistry.

[35]  A. Dick,et al.  Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. , 2007, The American journal of pathology.

[36]  B. Ryffel,et al.  Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection , 2007, The Journal of Immunology.

[37]  J. M. Izquierdo,et al.  Two Isoforms of the T-cell Intracellular Antigen 1 (TIA-1) Splicing Factor Display Distinct Splicing Regulation Activities , 2007, Journal of Biological Chemistry.

[38]  M. Mochizuki,et al.  The Role of Soluble TNF Receptors for TNF-α in Uveitis , 2007 .

[39]  R. Nussenblatt,et al.  TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 , 2007, Nature Medicine.

[40]  J. Myśliwska,et al.  Serum TNF-Alpha Level Predicts Nonproliferative Diabetic Retinopathy in Children , 2007, Mediators of inflammation.

[41]  Kaleb M. Pauley,et al.  The role of GW/P-bodies in RNA processing and silencing , 2007, Journal of Cell Science.

[42]  R. Caspi,et al.  IL-23 and IL-17 in pathogenesis of experimental ocular autoimmunity: requirement for IL–23 may extend beyond its role in sustaining the IL-17 effector response (129.26) , 2007, The Journal of Immunology.

[43]  J. Steitz,et al.  AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2 , 2007, Cell.

[44]  M. Zheng,et al.  Tumor necrosis factor alpha and macrophages in the brain of herpes simplex virus type 1-infected BALB/c mice , 2006, Journal of NeuroVirology.

[45]  Lei Sun,et al.  Tristetraprolin (TTP)-14-3-3 Complex Formation Protects TTP from Dephosphorylation by Protein Phosphatase 2a and Stabilizes Tumor Necrosis Factor-α mRNA* , 2006, Journal of Biological Chemistry.

[46]  T. Huizinga,et al.  Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis. , 2006, Current opinion in investigational drugs.

[47]  P. Blackshear,et al.  Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity , 2006, European journal of immunology.

[48]  Hum Chung,et al.  Intraocular cytokine environment in active Behçet uveitis. , 2006, American journal of ophthalmology.

[49]  D. Baltimore,et al.  NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses , 2006, Proceedings of the National Academy of Sciences.

[50]  T. Lawrence,et al.  Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1 , 2006, The Journal of experimental medicine.

[51]  P. Blackshear,et al.  Interferons limit inflammatory responses by induction of tristetraprolin. , 2006, Blood.

[52]  L. Trümper,et al.  Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Matthew Brook,et al.  Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element , 2006, Molecular and Cellular Biology.

[54]  J. Mages,et al.  Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock , 2006, The Journal of experimental medicine.

[55]  A. Dick,et al.  A Selective Role for the TNF p55 Receptor in Autocrine Signaling following IFN-γ Stimulation in Experimental Autoimmune Uveoretinitis1 , 2005, The Journal of Immunology.

[56]  Jun Wang,et al.  Small-Molecule Inhibition of TNF-α , 2005, Science.

[57]  P. Blackshear,et al.  HuR as a negative posttranscriptional modulator in inflammation. , 2005, Molecular cell.

[58]  P. King,et al.  Novel DNA-binding properties of the RNA-binding protein TIAR , 2005, Nucleic acids research.

[59]  Rodolfo Marquez,et al.  The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1. , 2005, Immunity.

[60]  S. Lightman,et al.  Emerging approaches to the treatment of uveitis: patents of 2000 – 2004 , 2005, Expert opinion on therapeutic patents.

[61]  K. Pfeffer,et al.  The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games , 2005, Immunology.

[62]  Reto Guler,et al.  Contribution of transmembrane tumor necrosis factor to host defense against Mycobacterium bovis bacillus Calmette-guerin and Mycobacterium tuberculosis infections. , 2005, The American journal of pathology.

[63]  É. Khandjian,et al.  Fragile X-related Protein FXR1P Regulates Proinflammatory Cytokine Tumor Necrosis Factor Expression at the Post-transcriptional Level* , 2005, Journal of Biological Chemistry.

[64]  H. Hieronymus,et al.  A systems view of mRNP biology. , 2004, Genes & development.

[65]  P. Anderson,et al.  Stress granule assembly is mediated by prion-like aggregation of TIA-1. , 2004, Molecular biology of the cell.

[66]  M. Gorospe,et al.  AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. , 2004, The Journal of biological chemistry.

[67]  J. Forrester,et al.  The role of tumour necrosis factor (TNF-α) in experimental autoimmune uveoretinitis (EAU) , 2004, Progress in Retinal and Eye Research.

[68]  Silvia Kirchner,et al.  Effect of different tumor necrosis factor (TNF) reactive agents on reverse signaling of membrane integrated TNF in monocytes. , 2004, Cytokine.

[69]  A. Ammit,et al.  IL-17A augments TNF-alpha-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. , 2004, The Journal of allergy and clinical immunology.

[70]  Ulrich Schraermeyer,et al.  A central role for inflammation in the pathogenesis of diabetic retinopathy , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[71]  B. Oostra,et al.  Characterization of Fxr1 in Danio rerio; a simple vertebrate model to study costamere development , 2004, Journal of Experimental Biology.

[72]  T. Tuschl,et al.  Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. , 2004, Molecular cell.

[73]  Brigitte Bogert,et al.  The fragile X-related Gene Affects the Crawling Behavior of Drosophila Larvae by Regulating the mRNA Level of the DEG/ENaC Protein Pickpocket1 , 2004, Current Biology.

[74]  J. Forrester,et al.  Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis. , 2004, Archives of ophthalmology.

[75]  Xi He,et al.  LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way , 2004, Development.

[76]  P. Anderson,et al.  MK2‐induced tristetraprolin:14‐3‐3 complexes prevent stress granule association and ARE‐mRNA decay , 2004, The EMBO journal.

[77]  J. Shabanowitz,et al.  MAPKAP Kinase 2 Phosphorylates Tristetraprolin on in Vivo Sites Including Ser178, a Site Required for 14-3-3 Binding* , 2004, Journal of Biological Chemistry.

[78]  A. Dick,et al.  Systemic CD4+ T cell phenotype and activation status in intermediate uveitis , 2004, British Journal of Ophthalmology.

[79]  P. Blackshear,et al.  Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor α, cyclooxygenase 2, and inflammatory arthritis , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[80]  K. Hashimoto,et al.  Absence of tumour necrosis factor facilitates primary and recurrent herpes simplex virus-1 infections. , 2004, The Journal of general virology.

[81]  Daniela C. Zarnescu,et al.  Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway , 2004, Nature Neuroscience.

[82]  S. Ceman,et al.  Phosphorylation influences the translation state of FMRP-associated polyribosomes. , 2003, Human molecular genetics.

[83]  Kotaro Suzuki,et al.  IL-4–Stat6 Signaling Induces Tristetraprolin Expression and Inhibits TNF-α Production in Mast Cells , 2003, The Journal of experimental medicine.

[84]  M. Hatzoglou,et al.  Chronic Ethanol Exposure Increases the Binding of HuR to the TNFα 3′-Untranslated Region in Macrophages* , 2003, Journal of Biological Chemistry.

[85]  Shyamasree Datta,et al.  TGFβ inhibits LPS-induced chemokine mRNA stabilization , 2003 .

[86]  K. Ogawa,et al.  Transcriptional Regulation of Tristetraprolin by Transforming Growth Factor-β in Human T Cells* , 2003, Journal of Biological Chemistry.

[87]  M. Magnasco,et al.  Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. , 2003, Genome research.

[88]  Damien Chaussabel,et al.  Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. , 2003, Blood.

[89]  J. Dean,et al.  Post‐transcriptional regulation of gene expression by mitogen‐activated protein kinase p38 , 2003, FEBS letters.

[90]  J. Forrester,et al.  Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis. , 2003, Investigative ophthalmology & visual science.

[91]  G. Stoecklin,et al.  A Constitutive Decay Element Promotes Tumor Necrosis Factor Alpha mRNA Degradation via an AU-Rich Element-Independent Pathway , 2003, Molecular and Cellular Biology.

[92]  J. Valcárcel,et al.  The splicing regulator TIA‐1 interacts with U1‐C to promote U1 snRNP recruitment to 5′ splice sites , 2002, The EMBO journal.

[93]  Peter Scheurich,et al.  Control of Receptor-induced Signaling Complex Formation by the Kinetics of Ligand/Receptor Interaction* , 2002, The Journal of Biological Chemistry.

[94]  É. Khandjian,et al.  Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression. , 2002, Human molecular genetics.

[95]  P. Anderson,et al.  Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. , 2002, Biochemical Society transactions.

[96]  J. Forrester,et al.  Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. , 2002, The American journal of pathology.

[97]  A. Caudy,et al.  Fragile X-related protein and VIG associate with the RNA interference machinery. , 2002, Genes & development.

[98]  M. Siomi,et al.  A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. , 2002, Genes & development.

[99]  J. Forrester,et al.  Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. , 2002, Investigative ophthalmology & visual science.

[100]  M. Yaffe,et al.  Cytoplasmic Localization of Tristetraprolin Involves 14-3-3-dependent and -independent Mechanisms* , 2002, The Journal of Biological Chemistry.

[101]  M. Feldmann,et al.  Development of anti-TNF therapy for rheumatoid arthritis , 2002, Nature Reviews Immunology.

[102]  R. Guler,et al.  Transmembrane TNF Induces an Efficient Cell-Mediated Immunity and Resistance to Mycobacterium bovis Bacillus Calmette-Guérin Infection in the Absence of Secreted TNF and Lymphotoxin-α1 , 2002, The Journal of Immunology.

[103]  G. Kollias,et al.  MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels* , 2002, The Journal of Biological Chemistry.

[104]  E. Lander,et al.  Human macrophage activation programs induced by bacterial pathogens , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[105]  P. Blackshear Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover. , 2001, Biochemical Society transactions.

[106]  D. Nelson,et al.  Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2. , 2001, Genomics.

[107]  J. Darnell,et al.  Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function , 2001, Cell.

[108]  J. Darnell,et al.  Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome , 2001, Cell.

[109]  J. Ting,et al.  TNFα promotes proliferation of oligodendrocyte progenitors and remyelination , 2001, Nature Neuroscience.

[110]  P. Blackshear,et al.  Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. , 2001, Blood.

[111]  Joseph Keane,et al.  Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent , 2001 .

[112]  J. Cyster,et al.  Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. , 2001, Immunity.

[113]  K. Mahtani,et al.  Mitogen-Activated Protein Kinase p38 Controls the Expression and Posttranslational Modification of Tristetraprolin, a Regulator of Tumor Necrosis Factor Alpha mRNA Stability , 2001, Molecular and Cellular Biology.

[114]  E. Collantes Estévez,et al.  Aqueous Humor and Serum Tumor Necrosis Factor-α in Clinical Uveitis , 2001, Ophthalmic Research.

[115]  G. Stoecklin,et al.  Mitogen-Activated Protein Kinase Phosphatidylinositol 3-Kinase and p 38 Interleukin-3 mRNA Turnover by Parallel and Independent Regulation of , 2001 .

[116]  S. Warren,et al.  The fragile X mental retardation protein inhibits translation via interacting with mRNA. , 2001, Nucleic acids research.

[117]  A. Ostareck-Lederer,et al.  Evidence that fragile X mental retardation protein is a negative regulator of translation. , 2001, Human molecular genetics.

[118]  K. Mahtani,et al.  The 3′ Untranslated Region of Tumor Necrosis Factor Alpha mRNA Is a Target of the mRNA-Stabilizing Factor HuR , 2001, Molecular and Cellular Biology.

[119]  Takahiko Horiuchi,et al.  Outside-to-Inside Signal Through the Membrane TNF-α Induces E-Selectin (CD62E) Expression on Activated Human CD4+ T Cells1 , 2001, The Journal of Immunology.

[120]  J. Valcárcel,et al.  The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. , 2000, Molecular cell.

[121]  J. Saklatvala,et al.  Regulation of tumour necrosis factor α mRNA stability by the mitogen‐activated protein kinase p38 signalling cascade , 2000, FEBS letters.

[122]  J. Stévenin,et al.  The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site , 2000, Molecular and Cellular Biology.

[123]  P. Anderson,et al.  TIA‐1 is a translational silencer that selectively regulates the expression of TNF‐α , 2000 .

[124]  Gary Brewer,et al.  Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade , 2000, Molecular and Cellular Biology.

[125]  G. Firestein,et al.  Expression and function of wingless and frizzled homologs in rheumatoid arthritis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[126]  J. Cyster,et al.  Tumor necrosis factor: a master-regulator of leukocyte movement. , 2000, Immunology today.

[127]  Wei Li,et al.  RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2α to the Assembly of Mammalian Stress Granules , 1999, The Journal of cell biology.

[128]  J D Gottsch,et al.  Oxidative damage and age-related macular degeneration. , 1999, Molecular vision.

[129]  Jonathan A. Cooper,et al.  Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways , 1999, Molecular and Cellular Biology.

[130]  Klaus Resch,et al.  The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism , 1999, The EMBO journal.

[131]  D. Paty,et al.  TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study , 1999, Neurology.

[132]  S. Lightman,et al.  Increased CD4+ expression and decreased IL-10 in the anterior chamber in idiopathic uveitis. , 1999, Investigative ophthalmology & visual science.

[133]  J. Noseworthy,et al.  Targeting immunotherapy in multiple sclerosis , 1999, Neurology.

[134]  D. Nelson,et al.  Alternative splicing in the murine and human FXR1 genes. , 1999, Genomics.

[135]  M. Gaestel,et al.  MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis , 1999, Nature Cell Biology.

[136]  P. Blackshear,et al.  Necrosis Factor Alpha Mrna Deadenylation and Destabilization of Tumor Au-rich Elements and Promotes the Evidence That Tristetraprolin Binds To , 1999 .

[137]  J. Katz,et al.  In Autoimmune Diabetes the Transition from Benign to Pernicious Insulitis Requires an Islet Cell Response to Tumor Necrosis Factor α , 1999, The Journal of experimental medicine.

[138]  G. Hirose,et al.  Binding of neuronal ELAV‐like proteins to the uridine‐rich sequence in the 3′‐untranslated region of tumor necrosis factor‐α messenger RNA , 1999, FEBS letters.

[139]  N. Rooijen,et al.  Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system. , 1999, Journal of immunology.

[140]  M. Pasparakis,et al.  TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein‐induced experimental autoimmune encephalomyelitis , 1999, European journal of immunology.

[141]  G. Kollias,et al.  Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. , 1999, Immunity.

[142]  P. Ward,et al.  In vitro and in vivo dependency of chemokine generation on C5a and TNF-alpha. , 1999, Journal of immunology.

[143]  K. Frei,et al.  Severity of symptoms and demyelination in MOG‐induced EAE depends on TNFR1 , 1999, European journal of immunology.

[144]  Georges Huez,et al.  Identification of TIAR as a Protein Binding to the Translational Regulatory AU-rich Element of Tumor Necrosis Factor α mRNA* , 1999, The Journal of Biological Chemistry.

[145]  J. Steitz,et al.  HNS, a nuclear-cytoplasmic shuttling sequence in HuR. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[146]  U. Atasoy,et al.  ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. , 1998, Journal of cell science.

[147]  P. Hodgkin,et al.  Generation of Splenic Follicular Structure and B Cell Movement in Tumor Necrosis Factor–deficient Mice , 1998, The Journal of experimental medicine.

[148]  P. Blackshear,et al.  Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin , 1998 .

[149]  J. Steitz,et al.  Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs , 1998, The EMBO journal.

[150]  A. Dick,et al.  Neutralizing TNF-alpha activity modulates T-cell phenotype and function in experimental autoimmune uveoretinitis. , 1998, Journal of autoimmunity.

[151]  J. Pollard,et al.  Challenging Cytokine Redundancy: Inflammatory Cell Movement and Clinical Course of Experimental Autoimmune Encephalomyelitis Are Normal in Lymphotoxin-deficient, but Not Tumor Necrosis Factor–deficient, Mice , 1998, The Journal of experimental medicine.

[152]  R. Ransohoff,et al.  Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation? , 1998, Trends in Neurosciences.

[153]  J. Forrester,et al.  Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats. , 1998, Current eye research.

[154]  P. Scheurich,et al.  Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1 , 1998, European journal of immunology.

[155]  J. Pollard,et al.  Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting , 1997, The Journal of experimental medicine.

[156]  S. McColl,et al.  Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. , 1997, Journal of immunology.

[157]  C. Ambrose,et al.  Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes. , 1997, Journal of immunology.

[158]  H. Boehmer,et al.  Lymphotoxins: from cytotoxicity to lymphoid organogenesis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[159]  J. Keene,et al.  Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. , 1997, American journal of human genetics.

[160]  G. Kollias,et al.  Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[161]  G. Kollias,et al.  Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling , 1997, The Journal of experimental medicine.

[162]  K. Okumura,et al.  Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin‐12 , 1997, European journal of immunology.

[163]  Nicole Nelson,et al.  A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells , 1997, Nature.

[164]  G. Kollias,et al.  Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response , 1996, The Journal of experimental medicine.

[165]  P. Anderson,et al.  Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. , 1996, Nucleic acids research.

[166]  C. Chan,et al.  Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. , 1996, Journal of immunology.

[167]  S. Warren,et al.  The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. , 1996, Human molecular genetics.

[168]  J. Forrester,et al.  Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina , 1996, European journal of immunology.

[169]  B. Haynes,et al.  A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. , 1996, Immunity.

[170]  Anne Wright,et al.  Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein (*) , 1996, The Journal of Biological Chemistry.

[171]  L. Dember,et al.  Individual RNA Recognition Motifs of TIA-1 and TIAR Have Different RNA Binding Specificities (*) , 1996, The Journal of Biological Chemistry.

[172]  George Kollias,et al.  The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor , 1995, Cell.

[173]  C. Y. Chen,et al.  AU-rich elements: characterization and importance in mRNA degradation. , 1995, Trends in biochemical sciences.

[174]  S. Nedospasov,et al.  Lipopolysaccharide-induced expression of TNF-alpha gene in the macrophage cell line ANA-1 is regulated at the level of transcription processivity. , 1995, Journal of immunology.

[175]  R. Nussbaum,et al.  FXR1, an autosomal homolog of the fragile X mental retardation gene. , 1995, The EMBO journal.

[176]  P. Good A conserved family of elav-like genes in vertebrates. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[177]  C. Disteche,et al.  Intron-exon organization and chromosomal localization of the human TIA-1 gene. , 1994, Journal of immunology.

[178]  J. Keene,et al.  Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[179]  G. Kaplan,et al.  Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation , 1993, The Journal of experimental medicine.

[180]  Y. Vodovotz,et al.  Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. , 1992, The Journal of biological chemistry.

[181]  M. Streuli,et al.  Identification and functional characterization of a TIA-1-related nucleolysin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[182]  R. Nussenblatt Proctor Lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. , 1991, Investigative ophthalmology & visual science.

[183]  Paul Anderson,et al.  A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells , 1991, Cell.

[184]  J. Henson,et al.  HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal , 1991, Cell.

[185]  B. Beutler,et al.  Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions. , 1991, Journal of immunology.

[186]  L. Lau,et al.  A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. , 1990, The Journal of biological chemistry.

[187]  F. Dautry,et al.  RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2 , 1990, Molecular and cellular biology.

[188]  R. Clark,et al.  An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis , 1990, The Journal of experimental medicine.

[189]  Jiahuai Han,et al.  Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level [published erratum appears in J Exp Med 1990 Mar 1;171(3):971-2] , 1990, The Journal of experimental medicine.

[190]  S. Zuckerman,et al.  Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression. , 1989, Journal of immunology.

[191]  Luis Carrasco,et al.  Human gamma interferon and tumor necrosis factor exert a synergistic blockade on the replication of herpes simplex virus , 1989, Journal of virology.

[192]  J. Rosenbaum,et al.  Ocular inflammatory effects of intravitreally-injected tumor necrosis factor. , 1988, The American journal of pathology.

[193]  G. Shaw,et al.  A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation , 1986, Cell.

[194]  B. Beutler,et al.  Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. , 1986, Science.

[195]  B. Beutler,et al.  Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[196]  I. Gery,et al.  T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. , 1986, Journal of immunology.

[197]  L. Old,et al.  Tumor necrosis factor (TNF). , 1985, Science.

[198]  B. Beutler,et al.  Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. , 1985, Science.

[199]  J. Myśliwska,et al.  The role of vascular endothelial growth factor, tumor necrosis factor alpha and interleukin-6 in pathogenesis of diabetic retinopathy. , 2008, Diabetes research and clinical practice.

[200]  J. Forrester,et al.  Anti-TNFalpha therapy modulates the phenotype of peripheral blood CD4+ T cells in patients with posterior segment intraocular inflammation. , 2004, Investigative ophthalmology & visual science.

[201]  Stephen T Warren,et al.  A decade of molecular studies of fragile X syndrome. , 2002, Annual review of neuroscience.

[202]  Tala Bakheet,et al.  ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins , 2001, Nucleic Acids Res..

[203]  M. Gaestel,et al.  Kotlyarov, A. et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat. Cell Biol. 1, 94-97 , 1999 .

[204]  M. Ni,et al.  LIPOSOME-ENCAPSULATED CLODRONATE RETARDS THE DEVELOPMENT OF EXPERIMENTAL AUTOIMMUNE UVEITIS , 1998 .

[205]  P. Vassalli,et al.  The pathophysiology of tumor necrosis factors. , 1992, Annual review of immunology.

[206]  D. Falke,et al.  In vivo protective effect of tumour necrosis factor alpha against experimental infection with herpes simplex virus type 1. , 1991, The Journal of general virology.