3D integration in biochips: New proposed architectures for 3D applications in ATDA based digital microfluidic biochips

Digital microfluidic biochip (DMFB), a latest invention in lab-on-a-chip devices integrates electronics with biology for development of customized miniature devices intended for new application areas namely clinical diagnostics and detection, DNA analysis, point-of-care applications and so on. All-Terrain droplet actuation (ATDA) based biochips have (has) recently been emerged as the new variant in DMFB devices for application in 3D domain. In this work, we explored the possibility of design optimization followed by development of design automation techniques specifically applicable in 3D biochips. We consider the advantages and issues involved in development and application of 3D based design. Accordingly we demonstrated few prescheduled bioassay execution in both 2D and 3D domain and the following enhancement in the route performance.

[1]  Yves Fouillet,et al.  3D droplet displacement in microfluidic systems by electrostatic actuation , 2007 .

[2]  Fei Su,et al.  Computer-Aided Design and Test for Digital Microfluidics , 2007, IEEE Design & Test of Computers.

[3]  Christian Druon,et al.  Plateforme saw dédiée à la microfluidique discrète pour applications biologiques , 2004 .

[4]  Jean Berthier,et al.  Microdrops and digital microfluidics , 2008 .

[5]  Chang-Jin Kim,et al.  Addressable micro liquid handling by electric control of surface tension , 2001, Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090).

[6]  Philippe Dubois,et al.  Actuation potentials and capillary forces in electrowetting based microsystems , 2007 .

[7]  3D Droplet Actuation in Digital Microfluidics Devices , 2007, TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference.

[8]  Richard B. Fair,et al.  Digital microfluidics: is a true lab-on-a-chip possible? , 2007 .

[9]  Sigurd Wagner,et al.  Thermocapillary actuation of droplets on chemically patterned surfaces by programmable microheater arrays , 2003 .

[10]  Mohamed Abdelgawad,et al.  All-terrain droplet actuation. , 2008, Lab on a chip.

[11]  M. Shanahan,et al.  Drop Motion on an Inclined Plane and Evaluation of Hydrophobia Treatments to Glass , 1995 .

[12]  R. Fair,et al.  Electrowetting-based actuation of liquid droplets for microfluidic applications , 2000 .

[13]  F. Brochard,et al.  Motions of droplets on solid surfaces induced by chemical or thermal gradients , 1989 .

[14]  J. McLaughlin,et al.  Experiments on the motion of drops on a horizontal solid surface due to a wettability gradient. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[15]  Krishnendu Chakrabarty,et al.  Design automation methods and tools for microfluidics-based biochips , 2006 .

[16]  Peter R. C. Gascoyne,et al.  Dielectrophoresis-based sample handling in general-purpose programmable diagnostic instruments , 2004, Proceedings of the IEEE.

[17]  S. Cho,et al.  Towards digital microfluidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation , 2002, Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266).

[18]  Shih-Kang Fan,et al.  3D Droplet Transportation by EWOD Actuations on Flexible Polymer Films , 2005 .

[19]  Fei Su,et al.  Digital Microfluidic Biochips - Synthesis, Testing, and Reconfiguration Techniques , 2006 .

[20]  W. Sierpinski,et al.  Sur le probléme des courbes gauches en Topologie , 2022 .