Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography.

[1]  Peter Boesiger,et al.  Quantitative 1H MRS of the human brain in vivo based on the simulation phantom calibration strategy , 1998, Magnetic resonance in medicine.

[2]  P F Renshaw,et al.  A technique for detecting GABA in the human brain with PRESS localization and optimized refocusing spectral editing radiofrequency pulses , 1996, Magnetic resonance in medicine.

[3]  R. Mattson,et al.  Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose , 1996, Neurology.

[4]  I. Savic,et al.  Cortical Benzodiazepine Receptor Changes are Related to Frequency of Partial Seizures: A Positron Emission Tomography Study , 1996, Epilepsia.

[5]  R. Mattson,et al.  The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy , 1996, Annals of neurology.

[6]  K. Behar,et al.  Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy , 1995, Acta neurologica Scandinavica. Supplementum.

[7]  L. Medina-Kauwe,et al.  gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. , 1995, Comparative biochemistry and physiology. Part A, Physiology.

[8]  L Cinotti,et al.  Parameter and index images of benzodiazepine receptor concentration in the brain. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  R. Mattson,et al.  Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain , 1995, Epilepsia.

[10]  D R Fish,et al.  Benzodiazepine‐GABAA Receptors in Idiopathic Generalized Epilepsy Measured with [11C]Flumazenil and Positron Emission Tomography , 1995, Epilepsia.

[11]  K. Behar,et al.  Analysis of macromolecule resonances in 1H NMR spectra of human brain , 1994, Magnetic resonance in medicine.

[12]  K. Behar,et al.  Measurement of GABA following GABA‐transaminase inhibition by gabaculine: A 1H and 31P NMR spectroscopic study of rat brain in vivo , 1994, Magnetic resonance in medicine.

[13]  R. Mattson,et al.  Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. Wilman,et al.  In Vivo NMR Detection Strategies for γ-Aminobutyric Acid, Utilizing Proton Spectroscopy and Coherence-Pathway Filtering with Gradients , 1993 .

[15]  A. Sabers,et al.  Pharmacology of vigabatrin. , 1992, Pharmacology & toxicology.

[16]  A. Richens Pharmacology and Clinical Pharmacology of Vigabatrin , 1991, Journal of child neurology.

[17]  D E Kuhl,et al.  Compartmental Analysis of [11C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  G. Blomqvist,et al.  Cortical Benzodiazepine Receptor Binding in Patients with Generalized and Partial Epilepsy , 1990, Epilepsia.

[19]  P. D. De Deyn,et al.  Epilepsy and the GABA-hypothesis a brief review and some examples. , 1990, Acta neurologica Belgica.

[20]  P. Schechter,et al.  Clinical pharmacology of vigabatrin. , 1989, British journal of clinical pharmacology.

[21]  G. Mckinnon,et al.  A one‐shot lactate‐editing sequence for localized whole‐body spectroscopy , 1988, Magnetic resonance in medicine.

[22]  P. Bosiger,et al.  Localized double‐quantum filter and correlation spectroscopy experiments , 1988, Magnetic resonance in medicine.

[23]  R G Shulman,et al.  1H homonuclear editing of rat brain using semiselective pulses. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[24]  D Comar,et al.  Kinetics and displacement of [11C]RO 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography. , 1985, European journal of pharmacology.

[25]  G. Bartholini GABA receptor agonists: Pharmacological spectrum and therapeutic actions , 1985, Medicinal research reviews.

[26]  D Comar,et al.  Synthesis of ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo [1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography. , 1984, The International journal of applied radiation and isotopes.

[27]  A. Sjoerdsma,et al.  Biochemical and clinical effects of γ‐vinyl GABA in patients with epilepsy , 1984, Neurology.

[28]  Richard R. Ernst,et al.  Product operator formalism for the description of NMR pulse experiments , 1984 .

[29]  J. Richards,et al.  Agonist and antagonist benzodiazepine receptor interaction in vitro , 1981, Nature.