Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

[1]  Alberto Pupi,et al.  Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults , 2018, Neurology.

[2]  Emily C Turner,et al.  Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits , 2018, Aging cell.

[3]  Alzheimer’s Association 2018 Alzheimer's disease facts and figures , 2018, Alzheimer's & Dementia.

[4]  R. Canfield,et al.  Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double‐blind, controlled feeding study , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  L. Denner,et al.  Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease , 2017, Neurobiology of Aging.

[6]  J. Blusztajn,et al.  Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice , 2017, PloS one.

[7]  E. Mufson,et al.  Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring , 2017, Neuroscience.

[8]  Kara Dolinski,et al.  The BioGRID interaction database: 2017 update , 2016, Nucleic Acids Res..

[9]  P. Lewczuk,et al.  Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta , 2016, Journal of neurochemistry.

[10]  A. Caccamo,et al.  p62 improves AD-like pathology by increasing autophagy , 2016, Molecular Psychiatry.

[11]  A. Caccamo,et al.  Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease , 2016, Molecular Neurodegeneration.

[12]  Henning Hermjakob,et al.  The Reactome pathway Knowledgebase , 2015, Nucleic acids research.

[13]  Anushya Muruganujan,et al.  PANTHER version 10: expanded protein families and functions, and analysis tools , 2015, Nucleic Acids Res..

[14]  F. Sacks,et al.  MIND diet associated with reduced incidence of Alzheimer's disease , 2015, Alzheimer's & Dementia.

[15]  Liang Shen,et al.  Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses. , 2015, Journal of Alzheimer's disease : JAD.

[16]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[17]  E. Mufson,et al.  Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice , 2014, Neurobiology of Disease.

[18]  S. Merali,et al.  Homocysteine exacerbates β‐amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles , 2014, Annals of neurology.

[19]  M. Caudill,et al.  Maternal choline supplementation: a nutritional approach for improving offspring health? , 2014, Trends in Endocrinology & Metabolism.

[20]  I. Deary,et al.  Homocysteine, antioxidant micronutrients and late onset dementia , 2014, European Journal of Nutrition.

[21]  E. Mufson,et al.  Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome , 2013, Neurobiology of Disease.

[22]  L. Tan,et al.  Nutrition and the Risk of Alzheimer's Disease , 2013, BioMed research international.

[23]  Jing Wang,et al.  WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013 , 2013, Nucleic Acids Res..

[24]  L. Donner,et al.  Unusual Histologic Variant of a Low-Grade Fibromyxoid Sarcoma in a 3-Year-Old Boy with Complex Chromosomal Translocations Involving 7q34, 10q11.2, and 16p11.2 and Rearrangement of the FUS Gene , 2013, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[25]  C. Holmes,et al.  Microglial alterations in human Alzheimer's disease following Aβ42 immunization , 2011, Neuropathology and applied neurobiology.

[26]  Jia-min Zhuo,et al.  Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. , 2009, Current Alzheimer research.

[27]  M. Travisano,et al.  Methyl donor supplementation prevents transgenerational amplification of obesity , 2008, International Journal of Obesity.

[28]  Warren H. Meck,et al.  Developmental Periods of Choline Sensitivity Provide an Ontogenetic Mechanism for Regulating Memory Capacity and Age-Related Dementia , 2008, Frontiers in integrative neuroscience.

[29]  Henry Markram,et al.  A Novel Multiple Objective Optimization Framework for Constraining Conductance-Based Neuron Models by Experimental Data , 2007, Front. Neurosci..

[30]  N. Zawia,et al.  Environmental and dietary risk factors in Alzheimer’s disease , 2007, Expert review of neurotherapeutics.

[31]  K. Fuxe,et al.  Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease. , 2007, Journal of neural transmission.

[32]  M. Pappolla,et al.  Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels , 2006, Neurobiology of Disease.

[33]  R. Obeid,et al.  Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia , 2006, FEBS letters.

[34]  K. Fuxe,et al.  Aβ peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer’s disease , 2006, Journal of Neural Transmission.

[35]  Y. Terayama,et al.  Increase of total homocysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease. , 2005, Life sciences.

[36]  M. Katan,et al.  Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. , 2005, The American journal of clinical nutrition.

[37]  Joanna L. Jankowsky,et al.  Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase , 2004 .

[38]  J. Qiao,et al.  Homocysteine and Alzheimer's disease. , 1999, Nutrition reviews.

[39]  D. Borchelt,et al.  Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. , 2004, Human molecular genetics.

[40]  Robert A. Waterland,et al.  Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation , 2003, Molecular and Cellular Biology.

[41]  M. S. Morris Homocysteine and Alzheimer's disease , 2003, The Lancet Neurology.

[42]  W. Meck,et al.  Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan , 2003, Neuroscience & Biobehavioral Reviews.

[43]  M. Katan,et al.  Betaine supplementation lowers plasma homocysteine in healthy men and women. , 2003, The Journal of nutrition.

[44]  P. Ueland,et al.  Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. , 2003, Clinical chemistry.

[45]  M. Niculescu,et al.  Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. , 2002, The Journal of nutrition.

[46]  D. Ashline,et al.  Homocysteine potentiates β‐amyloid neurotoxicity: role of oxidative stress , 2001 .

[47]  D. Ashline,et al.  Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress. , 2001, Journal of neurochemistry.

[48]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[49]  Susumu Goto,et al.  KEGG: Kyoto Encyclopedia of Genes and Genomes , 2000, Nucleic Acids Res..

[50]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[51]  P. Ueland,et al.  Homocysteine in tissues of the mouse and rat. , 1984, The Journal of biological chemistry.