A cosmetic ‘anti-ageing’ product improves photoaged skin: a double-blind, randomized controlled trial

Summary Background Very few over‐the‐counter cosmetic ‘anti‐ageing’ products have been subjected to a rigorous double‐blind, vehicle‐controlled trial of efficacy. Previously we have shown that application of a cosmetic ‘anti‐ageing’ product to photoaged skin under occlusion for 12 days can stimulate the deposition of fibrillin‐1. This observation infers potential to repair and perhaps clinically improve photoaged skin.

[1]  S. Seité,et al.  Clinical, biometric and structural evaluation of the long‐term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin , 2008, Experimental dermatology.

[2]  J. Lademann,et al.  Infrared radiation-induced matrix metalloproteinase in human skin: implications for protection. , 2008, The Journal of investigative dermatology.

[3]  A V Rawlings,et al.  Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo , 2008, The British journal of dermatology.

[4]  Hsien-Cheh Chang,et al.  Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin , 2008, Archives of Dermatological Research.

[5]  C. Puglia,et al.  In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols. , 2008, Journal of cosmetic science.

[6]  R. Watson,et al.  Repair of photoaged dermal matrix by topical application of a cosmetic ‘antiageing’ product , 2007, The British journal of dermatology.

[7]  N. Sadick,et al.  Modulation of gene expression as a new skin anti-aging strategy. , 2007, Journal of drugs in dermatology : JDD.

[8]  R Bazin,et al.  Equivalence of face and volar forearm for the testing of moisturizing and firming effect of cosmetics in hydration and biomechanical studies , 2006, International journal of cosmetic science.

[9]  C. Griffiths,et al.  Retinoic acid receptor α expression and cutaneous ageing , 2004, Mechanisms of Ageing and Development.

[10]  J. Varani,et al.  All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture. , 2004, The American journal of pathology.

[11]  C. Griffiths,et al.  Retinoic acid receptor alpha expression and cutaneous ageing. , 2004, Mechanisms of ageing and development.

[12]  J. Voorhees,et al.  Matrix Metalloproteinase‐1 is the Major Collagenolytic Enzyme Responsible for Collagen Damage in UV‐irradiated Human Skin ¶ , 2003, Photochemistry and photobiology.

[13]  Hassan Zahouani,et al.  Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double‐blind study vs. placebo , 2003, Experimental dermatology.

[14]  J. Chung,et al.  Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. , 2001, The Journal of investigative dermatology.

[15]  C. Griffiths.  The role of retinoids in the prevention and repair of aged and photoaged skin , 2001, Clincal and Experimental Dermatology.

[16]  S. Kang,et al.  A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents. , 2001, The Journal of investigative dermatology.

[17]  J. Chung,et al.  Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. , 2000, The Journal of investigative dermatology.

[18]  C. Griffiths,et al.  Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction. , 1999, The Journal of investigative dermatology.

[19]  J. Voorhees,et al.  Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid. , 1999 .

[20]  C. Griffiths,et al.  Clinical features of photodamaged human skin are associated with a reduction in collagen VII , 1997, The British journal of dermatology.

[21]  T. Hamilton,et al.  Reduced type I and type III procollagens in photodamaged adult human skin. , 1995, The Journal of investigative dermatology.

[22]  T. Hamilton,et al.  Topical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial. , 1994, Journal of the American Academy of Dermatology.

[23]  T. Hamilton,et al.  Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid) , 1993, The New England journal of medicine.

[24]  J. Voorhees,et al.  Topical retinoic acid for photoaging: clinical response and underlying mechanisms. , 1993, Skin pharmacology : the official journal of the Skin Pharmacology Society.

[25]  T. Hamilton,et al.  A photonumeric scale for the assessment of cutaneous photodamage. , 1992, Archives of dermatology.

[26]  T. Hamilton,et al.  Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. , 1992, The New England journal of medicine.

[27]  G. M. Ridder,et al.  Age, sunlight, and facial skin: a histologic and quantitative study. , 1991, Journal of the American Academy of Dermatology.

[28]  T. Hamilton,et al.  Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin. , 1990, Journal of the American Academy of Dermatology.

[29]  T. Hamilton,et al.  Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils. A preliminary report. , 1990, JAMA.

[30]  T. Hamilton,et al.  Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. , 1988, JAMA.

[31]  R. Lavker,et al.  Aged skin: a study by light, transmission electron, and scanning electron microscopy. , 1987, The Journal of investigative dermatology.

[32]  A M Kligman,et al.  Topical tretinoin for photoaged skin. , 1986, Journal of the American Academy of Dermatology.

[33]  R. Timpl,et al.  Immunochemistry of elastotic material in sun-damaged skin. , 1986, The Journal of investigative dermatology.

[34]  I. Braverman,et al.  Studies in cutaneous aging: I. The elastic fiber network. , 1982, The Journal of investigative dermatology.

[35]  E. Davidson,et al.  Alterations in human dermal connective tissue with age and chronic sun damage. , 1962, The Journal of investigative dermatology.