Toward Biphasic Computed Tomography (CT) Enteric Contrast: Material Classification of Luminal Bismuth and Mural Iodine in a Small-Bowel Phantom Using Dual-Energy CT

Objective To develop dual-energy computed tomography methods for identification of hyperenhancing, hypoenhancing, and nonenhancing small-bowel pathologies. Methods Small-bowel phantoms simulating varying patient sizes and polyp types (hyperenhancing, hypoenhancing, and nonenhancing) contained bismuth suspension in the lumen. Dual-energy CT was performed at 80/140 kV and 100/140 kV. Computed tomographic number ratios (CT numbers at low/high kilovoltage) were calculated. Two radiologists evaluated polyp detection and conspicuity using bismuth-only, iodine-only, iodine-overlay, and mixed-kilovoltage displays. Results Computed tomographic ratios for bismuth and iodine did not overlap. For hyperenhancing and nonenhancing polyps at 80/140 kV, iodine-overlay display yielded higher detection rate (96%, 94%) and conspicuity score (3.5, 3.1) than mixed-kilovoltage images (88%, 68%; 1.5, 2.7). Mixed-kV images performed slightly better for hypoenhancing polyps (92%, 3.4 vs. <80%, <2.9). Similar results were observed at 100/140kV. Conclusions Dual-energy CT and a bismuth-containing enteric contrast permitted simultaneous identification of hyperenhancing, hypoenhancing, and nonenhancing polyps over a range of patient sizes.