Conservation of protein interaction network in evolution.

A functional analysis of protein fold interaction suggested that structural fold families have gradually acquired more diverse interacting partners while maintaining central biochemical interactions and functions. This means that the protein interaction network (map) maintains its robust architecture due to the functional constraints associated with the interactions.

[1]  Jong H. Park,et al.  Mapping protein family interactions: intramolecular and intermolecular protein family interaction repertoires in the PDB and yeast. , 2001, Journal of molecular biology.

[2]  Rolf Apweiler,et al.  The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 , 2000, Nucleic Acids Res..

[3]  Neil D. Rawlings,et al.  [2] Families of serine peptidases , 1994, Methods in Enzymology.

[4]  G. Farber,et al.  The structure and evolution of a/β barrel proteins , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  Z. X. Wang,et al.  How many fold types of protein are there in nature? , 1996, Proteins.

[6]  C. Chothia.  One thousand families for the molecular biologist , 1992, Nature.

[7]  C. Chothia,et al.  Intermediate sequences increase the detection of homology between sequences. , 1997, Journal of molecular biology.

[8]  Janet M. Thornton,et al.  Protein domain superfolds and superfamilies , 1994 .

[9]  C. Zhang,et al.  Relations of the numbers of protein sequences, families and folds. , 1997, Protein engineering.

[10]  N N Alexandrov,et al.  Biological meaning, statistical significance, and classification of local spatial similarities in nonhomologous proteins , 1994, Protein science : a publication of the Protein Society.

[11]  Chris Sander,et al.  Removing near-neighbour redundancy from large protein sequence collections , 1998, Bioinform..

[12]  T. Hunter,et al.  The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1 , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  A G Murzin,et al.  SCOP: a structural classification of proteins database for the investigation of sequences and structures. , 1995, Journal of molecular biology.