Source memory impairment in patients with frontal lobe lesions

In two experiments, we investigated memory for recently learned facts and memory for the source of the facts (i.e. where and when the facts were learned) in patients with frontal lobe lesions, age-matched elderly control subjects, and younger subjects. In both experiments, patients with frontal lobe lesions recalled as many facts as their age-matched subjects and the younger subjects, but they frequently attributed facts to incorrect sources. In the second experiment, both patients with frontal lobe lesions and their age-matched subjects committed more source errors than younger subjects. These findings suggest that the frontal lobes may play a special role in associating facts to the context in which they were learned. The results are also discussed in the light of the source memory impairment that occurs in amnesic patients.

[1]  Michael Petrides,et al.  Behavioural effects of frontal-lobe lesions in man , 1984, Trends in Neurosciences.

[2]  D. Schacter.  Memory, amnesia, and frontal lobe dysfunction , 1987, Psychobiology.

[3]  Daniel L. Schacter,et al.  Retrieval without Recollection: An Experimental Analysis of Source Amnesia , 1984 .

[4]  L. Squire.  Comparisons between forms of amnesia: some deficits are unique to Korsakoff's syndrome. , 1982, Journal of experimental psychology. Learning, memory, and cognition.

[5]  L. Nadel,et al.  Anterograde amnesia and memory for temporal order , 1981, Neuropsychologia.

[6]  D. Neary,et al.  Long term memory for famous voices in amnesic and normal subjects , 1980, Neuropsychologia.

[7]  E. Tulving.  Elements of episodic memory , 1983 .

[8]  J. Fuster.  The prefrontal cortex, mediator of cross-temporal contingencies. , 1985, Human neurobiology.

[9]  L R Squire,et al.  A neuropsychological study of fact memory and source amnesia. , 1987, Journal of experimental psychology. Learning, memory, and cognition.

[10]  L. Squire.  Memory and Brain , 1987 .

[11]  Brenda Milner,et al.  Differential effects of frontal-lobe lesions on cognitive estimation and spatial memory , 1984, Neuropsychologia.

[12]  Felicia A. Huppert,et al.  Recognition Memory in Amnesic Patients: Effect of Temporal Context and Familiarity of Material , 1976, Cortex.

[13]  K. Poeck,et al.  The influence of stretched speech presentation on token test performance of aphasic and right brain damaged patients , 1981, Neuropsychologia.

[14]  P. R. Meudell,et al.  Regency and Frequency Judgements in Alcoholic Amnesics and Normal People with Poor Memory , 1985, Cortex.

[15]  T. Salthouse.  Adult cognition : an experimental psychology of human aging / Timothy A. Salthouse , 1982 .

[16]  Characterizing amnesic patients for neurobehavioral study. , 1986 .

[17]  L. Squire,et al.  Cognitive impairment following frontal lobe damage and its relevance to human amnesia. , 1989 .

[18]  Raymond P. Kesner,et al.  Dissociation of item and order spatial memory in rats following medial prefrontal cortex lesions , 1987, Neuropsychologia.

[19]  Louis Narens,et al.  Norms of 300 general-information questions: Accuracy of recall, latency of recall, and feeling-of-knowing ratings. , 1980 .

[20]  E. Tulving,et al.  Episodic and semantic memory , 1972 .

[21]  F. Craik,et al.  Age differences in memory for item and source information. , 1987, Canadian journal of psychology.

[22]  Felicia A. Huppert,et al.  The Role of Trace Strength in Recency and Frequency Judgements by Amnesic and Control Subjects , 1978, The Quarterly journal of experimental psychology.

[23]  R. Church,et al.  Attention and the frontal cortex as examined by simultaneous temporal processing , 1988, Neuropsychologia.

[24]  M. Mishkin,et al.  Non-spatial memory after selective prefrontal lesions in monkeys , 1978, Brain Research.

[25]  Bruce T Volpe,et al.  Temporal order judgments with amnesia , 1982, Brain and Cognition.

[26]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[27]  F. J. Evans,et al.  Two types of posthypnotic amnesia: recall amnesia and source amnesia. , 1966, The International journal of clinical and experimental hypnosis.

[28]  L. Squire,et al.  Korsakoff's syndrome: radiological (CT) findings and neuropsychological correlates , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[29]  E. A. Berg,et al.  A simple objective technique for measuring flexibility in thinking. , 1948, The Journal of general psychology.

[30]  A. Pickering,et al.  Is Organic Amnesia Caused by a Selective Deficit in Remembering Contextual Information? , 1985, Cortex.

[31]  B. Milner,et al.  Frontal lobes and the temporal organization of memory. , 1985, Human neurobiology.