Fibroblast growth factor signaling in skeletal development and disease

In this review, Ornitz and Marie examine progress made on understanding the functions of the fibroblast growth factor (FGF) signaling pathway during critical stages of skeletogenesis and explore the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans.

[1]  Xiaobin Han,et al.  Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23. , 2015, The Journal of Biological Chemistry.

[2]  A. Uitterlinden,et al.  A novel variant of FGFR3 causes proportionate short stature. , 2015, European journal of endocrinology.

[3]  H. Akiyama,et al.  The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth , 2015, Scientific Reports.

[4]  P. Matula,et al.  Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage. , 2015, Biochimica et biophysica acta.

[5]  Florent Elefteriou,et al.  FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation. , 2015, Human molecular genetics.

[6]  D. Rimoin,et al.  Neutral Endopeptidase-Resistant C-Type Natriuretic Peptide Variant Represents a New Therapeutic Approach for Treatment of Fibroblast Growth Factor Receptor 3–Related Dwarfism , 2015, The Journal of Pharmacology and Experimental Therapeutics.

[7]  Y. Mishina,et al.  BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse. , 2015, Developmental biology.

[8]  P. Marie Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies , 2015, Cellular and Molecular Life Sciences.

[9]  H. Akiyama,et al.  Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. , 2015, Human molecular genetics.

[10]  N. Itoh,et al.  The Fibroblast Growth Factor signaling pathway , 2015, Wiley interdisciplinary reviews. Developmental biology.

[11]  A. Lassar,et al.  A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation , 2015, Development.

[12]  A. Aylsworth,et al.  C-type natriuretic peptide plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasia. , 2015, Journal of Clinical Endocrinology and Metabolism.

[13]  K. Mori,et al.  Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene. , 2015, Endocrinology.

[14]  K. von der Mark,et al.  Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice , 2014, PLoS genetics.

[15]  T. Doetschman,et al.  Knockout of Nuclear High Molecular Weight FGF2 Isoforms in Mice Modulates Bone and Phosphate Homeostasis* , 2014, The Journal of Biological Chemistry.

[16]  F. Berenbaum,et al.  Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function. , 2014, Osteoarthritis and cartilage.

[17]  S. Chatterjee,et al.  Role of angiogenesis in bone repair. , 2014, Archives of biochemistry and biophysics.

[18]  D. Krakow,et al.  Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription. , 2014, Human molecular genetics.

[19]  H. Kronenberg,et al.  A Subset of Chondrogenic Cells Provides Early Mesenchymal Progenitors in Growing Bones , 2014, Nature Cell Biology.

[20]  S. Ikegawa,et al.  Statin treatment rescues FGFR3 skeletal dysplasia phenotypes , 2014, Nature.

[21]  S. Liang,et al.  SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters , 2014, PloS one.

[22]  A. Lassar,et al.  Fibroblast growth factor maintains chondrogenic potential of limb bud mesenchymal cells by modulating DNMT3A recruitment. , 2014, Cell reports.

[23]  Derrick J. Morton,et al.  Snail Promotes Epithelial Mesenchymal Transition in Breast Cancer Cells in Part via Activation of Nuclear ERK2 , 2014, PloS one.

[24]  Xiaobin Han,et al.  Osteocyte-Specific Deletion of Fgfr1 Suppresses FGF23 , 2014, PloS one.

[25]  Liu Yang,et al.  Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation , 2014, Proceedings of the National Academy of Sciences.

[26]  S. Antonarakis,et al.  A Novel Homozygous Mutation in FGFR3 Causes Tall Stature, Severe Lateral Tibial Deviation, Scoliosis, Hearing Impairment, Camptodactyly, and Arachnodactyly , 2014, Human mutation.

[27]  K. Moriyama,et al.  Therapeutic Effect of Nanogel-Based Delivery of Soluble FGFR2 with S252W Mutation on Craniosynostosis , 2014, PloS one.

[28]  K. White,et al.  Hypophosphatemic Rickets: Revealing Novel Control Points for Phosphate Homeostasis , 2014, Current Osteoporosis Reports.

[29]  C. Deng,et al.  FGFR3 induces degradation of BMP type I receptor to regulate skeletal development. , 2014, Biochimica et biophysica acta.

[30]  J. Esko,et al.  Demystifying heparan sulfate-protein interactions. , 2014, Annual review of biochemistry.

[31]  J. Richtsmeier,et al.  Morphological comparison of the craniofacial phenotypes of mouse models expressing the Apert FGFR2 S252W mutation in neural crest- or mesoderm-derived tissues. , 2014, Bone.

[32]  B. Olsen,et al.  Distinct VEGF Functions During Bone Development and Homeostasis , 2014, Archivum Immunologiae et Therapiae Experimentalis.

[33]  C. Deng,et al.  Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model , 2014, Developmental dynamics : an official publication of the American Association of Anatomists.

[34]  D. Chan,et al.  The chondrocytic journey in endochondral bone growth and skeletal dysplasia. , 2014, Birth defects research. Part C, Embryo today : reviews.

[35]  J. Richtsmeier,et al.  Craniofacial divergence by distinct prenatal growth patterns in Fgfr2 mutant mice , 2014, BMC Developmental Biology.

[36]  H. Bae,et al.  Prolyl Isomerase Pin1-mediated Conformational Change and Subnuclear Focal Accumulation of Runx2 Are Crucial for Fibroblast Growth Factor 2 (FGF2)-induced Osteoblast Differentiation* , 2014, The Journal of Biological Chemistry.

[37]  Bo Zhang,et al.  A Ser252Trp Mutation in Fibroblast Growth Factor Receptor 2 (FGFR2) Mimicking Human Apert Syndrome Reveals an Essential Role for FGF Signaling in the Regulation of Endochondral Bone Formation , 2014, PloS one.

[38]  J. Ladbury,et al.  Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion , 2014, Nature Structural &Molecular Biology.

[39]  A. Munnich,et al.  FGFR3 mutation causes abnormal membranous ossification in achondroplasia. , 2014, Human molecular genetics.

[40]  T. Cho,et al.  Overgrowth syndrome associated with a gain‐of‐function mutation of the natriuretic peptide receptor 2 (NPR2) gene , 2014, American journal of medical genetics. Part A.

[41]  A. Masuda,et al.  Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia , 2013, PloS one.

[42]  M. Sabbieti,et al.  FGF‐2 enhances Runx‐2/Smads nuclear localization in BMP‐2 canonical signaling in osteoblasts , 2013, Journal of cellular physiology.

[43]  A. Uitterlinden,et al.  An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. , 2013, Journal of Clinical Endocrinology and Metabolism.

[44]  Y. Le Marchand-Brustel,et al.  Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice , 2013, Science Translational Medicine.

[45]  M. Van Hul,et al.  Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration. , 2013, Birth defects research. Part C, Embryo today : reviews.

[46]  A. Harris,et al.  Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer , 2013, British Journal of Cancer.

[47]  Michael J. Sweredoski,et al.  Activation of p107 by Fibroblast Growth Factor, Which Is Essential for Chondrocyte Cell Cycle Exit, Is Mediated by the Protein Phosphatase 2A/B55α Holoenzyme , 2013, Molecular and Cellular Biology.

[48]  J. Boulanger,et al.  New evidence for positive selection helps explain the paternal age effect observed in achondroplasia , 2013, Human molecular genetics.

[49]  Atum M. Buo,et al.  The regulation of runt‐related transcription factor 2 by fibroblast growth factor‐2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  T. Gridley,et al.  Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[51]  M. Mohammadi,et al.  Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology. , 2013, Cold Spring Harbor perspectives in biology.

[52]  K. White,et al.  Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia. , 2013, Bone.

[53]  M. Hurley,et al.  Fibroblast growth factor-2, bone homeostasis and fracture repair. , 2013, Current pharmaceutical design.

[54]  M. Sabbieti,et al.  BMP-2 differentially modulates FGF-2 isoform effects in osteoblasts from newborn transgenic mice. , 2013, Endocrinology.

[55]  V. Kolupaeva,et al.  The B55α Regulatory Subunit of Protein Phosphatase 2A Mediates Fibroblast Growth Factor-Induced p107 Dephosphorylation and Growth Arrest in Chondrocytes , 2013, Molecular and Cellular Biology.

[56]  T. Kwon,et al.  Craniosynostosis-Associated Fgfr2C342Y Mutant Bone Marrow Stromal Cells Exhibit Cell Autonomous Abnormalities in Osteoblast Differentiation and Bone Formation , 2013, BioMed research international.

[57]  Kevin W. Eliceiri,et al.  The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis , 2013, Nature Cell Biology.

[58]  W. Sellers,et al.  Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23‐mediated hypophosphatemic rickets , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  L. Charles,et al.  Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[60]  Eryuan Liao FGF23 associated bone diseases , 2013, Frontiers of Medicine.

[61]  R. Carano,et al.  Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia , 2013, PloS one.

[62]  M. Mohammadi,et al.  Exploring mechanisms of FGF signalling through the lens of structural biology , 2013, Nature Reviews Molecular Cell Biology.

[63]  N. Hatch,et al.  Further Analysis of the Crouzon Mouse: Effects of the FGFR2C342Y Mutation Are Cranial Bone–Dependent , 2013, Calcified Tissue International.

[64]  S. Knight,et al.  Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis , 2013, Nature Genetics.

[65]  Liping Xiao,et al.  Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[66]  P. Marie,et al.  E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis , 2013, Cell Death and Disease.

[67]  A. Munnich,et al.  Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. , 2012, American journal of human genetics.

[68]  Di Chen,et al.  Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. , 2012, Arthritis and rheumatism.

[69]  C. Xian,et al.  Role of FGFs/FGFRs in skeletal development and bone regeneration , 2012, Journal of cellular physiology.

[70]  P. Hurlin,et al.  Disruption of a Sox9-β-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. , 2012, Human molecular genetics.

[71]  M. Longaker,et al.  Craniosynostosis , 2012, Organogenesis.

[72]  C. Deng,et al.  Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia. , 2012, Human molecular genetics.

[73]  S. Iseki,et al.  Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts , 2012, Journal of cellular physiology.

[74]  H. Kim,et al.  Investigating the Role of FGF18 in the Cultivation and Osteogenic Differentiation of Mesenchymal Stem Cells , 2012, PloS one.

[75]  J. Henderson,et al.  FGF18 augments osseointegration of intra-medullary implants in osteopenic FGFR3(-/-) mice. , 2012, European cells & materials.

[76]  A. Papadimitropoulos,et al.  Fibroblast Growth Factor‐2 Maintains a Niche‐Dependent Population of Self‐Renewing Highly Potent Non‐adherent Mesenchymal Progenitors Through FGFR2c , 2012, Stem cells.

[77]  M. Hutchison BDNF alters ERK/p38 MAPK activity ratios to promote differentiation in growth plate chondrocytes. , 2012, Molecular endocrinology.

[78]  A. Munnich,et al.  An activating Fgfr3 mutation affects trabecular bone formation via a paracrine mechanism during growth. , 2012, Human molecular genetics.

[79]  Lukas Balek,et al.  Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation , 2012, PloS one.

[80]  V. Lefebvre,et al.  Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. , 2012, Developmental cell.

[81]  K. Lyons,et al.  Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. , 2012, American journal of human genetics.

[82]  M. Longaker,et al.  A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect model. , 2012, Tissue engineering. Part A.

[83]  A. Wilkie,et al.  Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. , 2012, American journal of human genetics.

[84]  M. Laederich,et al.  FGFR3 targeting strategies for achondroplasia , 2012, Expert Reviews in Molecular Medicine.

[85]  L. Quarles,et al.  Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism , 2012, Nature Reviews Endocrinology.

[86]  W. Wilcox,et al.  Sixteen years and counting: The current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias , 2012, Human mutation.

[87]  Y. Gho,et al.  DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling , 2012, Nature Communications.

[88]  Fanxin Long,et al.  Building strong bones: molecular regulation of the osteoblast lineage , 2011, Nature Reviews Molecular Cell Biology.

[89]  M. Passos-Bueno,et al.  FGFR2 Mutation Confers a Less Drastic Gain of Function in Mesenchymal Stem Cells Than in Fibroblasts , 2011, Stem Cell Reviews and Reports.

[90]  J. Nyman,et al.  Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. , 2011, Human molecular genetics.

[91]  T. Doetschman,et al.  Fibroblast Growth Factor 2 Stimulation of Osteoblast Differentiation and Bone Formation Is Mediated by Modulation of the Wnt Signaling Pathway* , 2011, The Journal of Biological Chemistry.

[92]  Y. Matsuda,et al.  Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo. , 2011, Developmental cell.

[93]  K. Mikecz,et al.  Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes , 2011, Arthritis research & therapy.

[94]  Jian Q. Feng,et al.  Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[95]  D. Coutu,et al.  Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells. , 2011, Blood.

[96]  M. Longaker,et al.  Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair. , 2011, Tissue engineering. Part A.

[97]  Takashi Nakamura,et al.  Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways , 2011, Development.

[98]  A. Kawanami,et al.  Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[99]  Matthew D. Kwan,et al.  Chemical Control of FGF-2 Release for Promoting Calvarial Healing with Adipose Stem Cells* , 2011, The Journal of Biological Chemistry.

[100]  Jennifer Liu,et al.  Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes , 2011, Development.

[101]  I. Palmeirim,et al.  Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development. , 2010, The International journal of developmental biology.

[102]  Kozo Nakamura,et al.  A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo‐controlled trial , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[103]  E. Jabs,et al.  Genetic basis of potential therapeutic strategies for craniosynostosis , 2010, American journal of medical genetics. Part A.

[104]  K. Cailliau,et al.  Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation , 2010, FEBS letters.

[105]  P. Marie,et al.  Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis , 2010, Science Signaling.

[106]  M. Leigheb,et al.  Regulation of osteoblast and osteoclast functions by FGF‐6 , 2010, Journal of cellular physiology.

[107]  M. Tohyama,et al.  bFGF Regulates PI3-Kinase-Rac1-JNK Pathway and Promotes Fibroblast Migration in Wound Healing , 2010, PloS one.

[108]  Geert Carmeliet,et al.  Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. , 2010, Developmental cell.

[109]  P. Marie,et al.  Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: Implication of FGFR2 signaling , 2010, Journal of cellular biochemistry.

[110]  T. Doetschman,et al.  Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. , 2010, Bone.

[111]  Franz Jakob,et al.  Autocrine fibroblast growth factor 18 mediates dexamethasone‐induced osteogenic differentiation of murine mesenchymal stem cells , 2010, Journal of cellular physiology.

[112]  M. Longaker,et al.  Fgf-9 is required for angiogenesis and osteogenesis in long bone repair , 2010, Proceedings of the National Academy of Sciences.

[113]  M. Nagata,et al.  FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line. , 2010, Journal of Electron Microscopy.

[114]  C. Deng,et al.  The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development , 2010, Science Signaling.

[115]  J. Ringe,et al.  Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis. , 2010, Human molecular genetics.

[116]  Di Chen,et al.  Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. , 2010, Human molecular genetics.

[117]  J. Richtsmeier,et al.  Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice , 2010, BMC Developmental Biology.

[118]  Yue Shen,et al.  Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathway. , 2009, Biochemical and biophysical research communications.

[119]  H. Ryoo,et al.  FGF2-activated ERK Mitogen-activated Protein Kinase Enhances Runx2 Acetylation and Stabilization* , 2009, The Journal of Biological Chemistry.

[120]  R. Zeller,et al.  Vertebrate limb bud development: moving towards integrative analysis of organogenesis , 2009, Nature Reviews Genetics.

[121]  Daniel J. O'Connell,et al.  Temporomandibular joint formation requires two distinct hedgehog-dependent steps , 2009, Proceedings of the National Academy of Sciences.

[122]  A. Kawanami,et al.  Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis , 2009, Molecular and Cellular Biology.

[123]  A. Lindahl,et al.  Identification of a stem cell niche in the zone of Ranvier within the knee joint , 2009, Journal of anatomy.

[124]  Wei Huang,et al.  Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. , 2009, American journal of human genetics.

[125]  P. Pollock,et al.  Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix , 2009, Molecular and Cellular Biology.

[126]  G. Stein,et al.  The heparan sulfate proteoglycan (HSPG) glypican‐3 mediates commitment of MC3T3‐E1 cells toward osteogenesis , 2009, Journal of cellular physiology.

[127]  G. Stein,et al.  The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts , 2009, Journal of cellular biochemistry.

[128]  Christian Wiesmann,et al.  Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. , 2009, The Journal of clinical investigation.

[129]  Joseph Schlessinger,et al.  FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma. , 2009, The Journal of clinical investigation.

[130]  C. Deng,et al.  Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. , 2009, Developmental biology.

[131]  T. Doetschman,et al.  Endogenous FGF‐2 is critically important in PTH anabolic effects on bone , 2009, Journal of cellular physiology.

[132]  M. Nagata,et al.  A local bone anabolic effect of rhFGF2-impregnated gelatin hydrogel by promoting cell proliferation and coordinating osteoblastic differentiation. , 2009, Bone.

[133]  D. Ornitz,et al.  Fibroblast growth factor expression during skeletal fracture healing in mice , 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

[134]  K. Moriyama,et al.  Fibroblast Growth Factor Receptor 2 Promotes Osteogenic Differentiation in Mesenchymal Cells via ERK1/2 and Protein Kinase C Signaling* , 2009, Journal of Biological Chemistry.

[135]  M. Longaker,et al.  Differential FGF Ligands and FGF Receptors Expression Pattern in Frontal and Parietal Calvarial Bones , 2009, Cells Tissues Organs.

[136]  Gillian M Morriss-Kay,et al.  Skeletal analysis of the Fgfr3P244R mouse, a genetic model for the Muenke craniosynostosis syndrome , 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

[137]  A. Munnich,et al.  Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia. , 2009, Biochimica et biophysica acta.

[138]  T. Doetschman,et al.  Exported 18-kDa Isoform of Fibroblast Growth Factor-2 Is a Critical Determinant of Bone Mass in Mice* , 2009, Journal of Biological Chemistry.

[139]  Makoto Taiji,et al.  FGF9 monomer/dimer equilibrium regulates extracellular matrix affinity and tissue diffusion , 2009, Nature Genetics.

[140]  L. Thompson,et al.  Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage , 2008, PloS one.

[141]  E. Wardelmann,et al.  Sustained Platelet-Derived Growth Factor Receptor α Signaling in Osteoblasts Results in Craniosynostosis by Overactivating the Phospholipase C-γ Pathway , 2008, Molecular and Cellular Biology.

[142]  E. Laplantine,et al.  PP2A-Mediated Dephosphorylation of p107 Plays a Critical Role in Chondrocyte Cell Cycle Arrest by FGF , 2008, PloS one.

[143]  A. Kawanami,et al.  FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. , 2008, Human molecular genetics.

[144]  R. Nusse,et al.  Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development , 2008, Development.

[145]  Su-jin Kim,et al.  Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways. , 2008, Stem cells and development.

[146]  M. Kuro-o Endocrine FGFs and Klothos: emerging concepts , 2008, Trends in Endocrinology & Metabolism.

[147]  J. Elisseeff,et al.  The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model. , 2008, Bone.

[148]  A. Sanjay,et al.  FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. , 2008, Bone.

[149]  Y. Giudicelli,et al.  Increased achondroplasia mutation frequency with advanced age and evidence for G1138A mosaicism in human testis biopsies. , 2008, Fertility and sterility.

[150]  D. Ambrosetti,et al.  Fibroblast Growth Factor Signaling Uses Multiple Mechanisms To Inhibit Wnt-Induced Transcription in Osteoblasts , 2008, Molecular and Cellular Biology.

[151]  P. Marie,et al.  Transcription factors controlling osteoblastogenesis. , 2008, Archives of biochemistry and biophysics.

[152]  G. Martin,et al.  Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning , 2008, Nature.

[153]  T. Doetschman,et al.  Reduced expression and function of bone morphogenetic protein‐2 in bones of Fgf2 null mice , 2008, Journal of cellular biochemistry.

[154]  A. Lichtler,et al.  Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones. , 2008, Developmental biology.

[155]  Xiaoling Xu,et al.  A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis. , 2008, Bone.

[156]  D. Ornitz,et al.  FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis , 2008, Development.

[157]  L. Thompson,et al.  STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes , 2008, Journal of Cell Science.

[158]  M. Sabbieti,et al.  Anti‐apoptotic Bcl‐2 enhancing requires FGF‐2/FGF receptor 1 binding in mouse osteoblasts , 2008, Journal of cellular physiology.

[159]  Miguel Manzanares,et al.  Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. , 2007, Developmental cell.

[160]  A. Wilkie Cancer drugs to treat birth defects , 2007, Nature Genetics.

[161]  X. Coumoul,et al.  RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis , 2007, Nature Genetics.

[162]  B. Hallgrímsson,et al.  Inactivation of Pten in Osteo‐Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[163]  H. Moriya,et al.  Effects of a Single Percutaneous Injection of Basic Fibroblast Growth Factor on the Healing of a Closed Femoral Shaft Fracture in the Rat , 2007, Calcified Tissue International.

[164]  D. Ornitz,et al.  FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. , 2007, Developmental biology.

[165]  R. Ravazzolo,et al.  Overexpression of the C‐type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation , 2007, Human mutation.

[166]  R. Serra,et al.  C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and – independent pathways , 2007, BMC Developmental Biology.

[167]  V. P. Eswarakumar,et al.  Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3 , 2007, Proceedings of the National Academy of Sciences.

[168]  S. Takai,et al.  Negative Regulation by p70 S6 Kinase of FGF‐2–Stimulated VEGF Release Through Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase in Osteoblasts , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[169]  J. Baron,et al.  Fibroblast growth factor expression in the postnatal growth plate. , 2007, Bone.

[170]  D. Ornitz,et al.  FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. , 2007, Developmental biology.

[171]  G. Stein,et al.  Heparan sulfate regulates the anabolic activity of MC3T3‐E1 preosteoblast cells by induction of Runx2 , 2007, Journal of cellular physiology.

[172]  Martina I Reinhold,et al.  Direct Interactions of Runx2 and Canonical Wnt Signaling Induce FGF18* , 2006, Journal of Biological Chemistry.

[173]  K. Okawa,et al.  Klotho converts canonical FGF receptor into a specific receptor for FGF23 , 2006, Nature.

[174]  V. P. Eswarakumar,et al.  Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis , 2006, Proceedings of the National Academy of Sciences.

[175]  M. Bamshad,et al.  A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome. , 2006, American journal of human genetics.

[176]  A. Oberbauer,et al.  Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 3. , 2006, Journal of animal science.

[177]  R. Behringer,et al.  Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. , 2006, Genes & development.

[178]  C. Lengner,et al.  Networks and hubs for the transcriptional control of osteoblastogenesis , 2006, Reviews in Endocrine and Metabolic Disorders.

[179]  M. Cunningham,et al.  Intracellular Retention, Degradation, and Signaling of Glycosylation-deficient FGFR2 and Craniosynostosis Syndrome-associated FGFR2C278F* , 2006, Journal of Biological Chemistry.

[180]  J. Partanen,et al.  Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. , 2006, Developmental biology.

[181]  G. Morriss-Kay,et al.  A model for the pharmacological treatment of crouzon syndrome. , 2006, Neurosurgery.

[182]  Riccardo Priore,et al.  Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes , 2006, Journal of cellular physiology.

[183]  D. Ornitz,et al.  Inhibition or Activation of Apert Syndrome FGFR2 (S252W) Signaling by Specific Glycosaminoglycans* , 2006, Journal of Biological Chemistry.

[184]  K. Rosenblatt,et al.  Regulation of Fibroblast Growth Factor-23 Signaling by Klotho* , 2006, Journal of Biological Chemistry.

[185]  Cristina M Furdui,et al.  Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction. , 2006, Molecular cell.

[186]  N. Cockett,et al.  A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep. , 2006, Animal genetics.

[187]  Ivan Dikic,et al.  The Cbl interactome and its functions , 2005, Nature Reviews Molecular Cell Biology.

[188]  J. Samarut,et al.  Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis. , 2005, Endocrinology.

[189]  M. Hurley,et al.  FGF and FGFR signaling in chondrodysplasias and craniosynostosis , 2005, Journal of cellular biochemistry.

[190]  C. Deng,et al.  FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis , 2005, Development.

[191]  T. Doetschman,et al.  Cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 is mediated by the MAPK cascade. , 2005, American journal of physiology. Heart and circulatory physiology.

[192]  Jamie M. Verheyden,et al.  Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning , 2005, Development.

[193]  J. Casal,et al.  Targeting the Extracellular Domain of Fibroblast Growth Factor Receptor 3 with Human Single-Chain Fv Antibodies Inhibits Bladder Carcinoma Cell Line Proliferation , 2005, Clinical Cancer Research.

[194]  Fan Yang,et al.  Abnormalities in cartilage and bone development in the Apert syndrome FGFR2+/S252W mouse , 2005, Development.

[195]  X. Coumoul,et al.  Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference , 2005, Nucleic acids research.

[196]  K. Nakao,et al.  Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells. , 2005, Bone.

[197]  P. Marie,et al.  A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome. , 2005, Human molecular genetics.

[198]  Toshihisa Komori,et al.  Runx2 regulates FGF2‐induced Bmp2 expression during cranial bone development , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[199]  C. Deng,et al.  Roles of FGF signaling in skeletal development and human genetic diseases. , 2005, Frontiers in bioscience : a journal and virtual library.

[200]  G. McVean,et al.  Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[201]  T. Tsuji,et al.  A Loss-of-Function Mutation in Natriuretic Peptide Receptor 2 (Npr2) Gene Is Responsible for Disproportionate Dwarfism in cn/cn Mouse* , 2005, Journal of Biological Chemistry.

[202]  D. Ovchinnikov,et al.  Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[203]  D. Ambrosetti,et al.  Mechanisms underlying differential responses to FGF signaling. , 2005, Cytokine & growth factor reviews.

[204]  D. Ornitz,et al.  FGF signaling in the developing endochondral skeleton. , 2005, Cytokine & growth factor reviews.

[205]  V. P. Eswarakumar,et al.  Cellular signaling by fibroblast growth factor receptors. , 2005, Cytokine & growth factor reviews.

[206]  D. Ambrosetti,et al.  Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation , 2005, The Journal of cell biology.

[207]  P. Marie,et al.  Cbl-mediated ubiquitination of α5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation , 2005, Journal of Cell Science.

[208]  Hiroyuki Nakaya,et al.  Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice. , 2005, Bone.

[209]  R. Kirschner,et al.  Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. , 2005, Bone.

[210]  K. White,et al.  Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. , 2005, American journal of human genetics.

[211]  S. Volinia,et al.  P253R fibroblast growth factor receptor‐2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation , 2005, Journal of cellular physiology.

[212]  K. Moriyama,et al.  A Soluble Form of Fibroblast Growth Factor Receptor 2 (FGFR2) with S252W Mutation Acts as an Efficient Inhibitor for the Enhanced Osteoblastic Differentiation Caused by FGFR2 Activation in Apert Syndrome* , 2004, Journal of Biological Chemistry.

[213]  Zhixiang Liao,et al.  FGF18 Represses Noggin Expression and Is Induced by Calcineurin* , 2004, Journal of Biological Chemistry.

[214]  J. Lemonnier,et al.  Cbl-mediated Degradation of Lyn and Fyn Induced by Constitutive Fibroblast Growth Factor Receptor-2 Activation Supports Osteoblast Differentiation* , 2004, Journal of Biological Chemistry.

[215]  Gillian M Morriss-Kay,et al.  A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[216]  O. Fromigué,et al.  Growth factors and bone formation in osteoporosis: roles for fibroblast growth factor and transforming growth factor beta. , 2004, Current pharmaceutical design.

[217]  E. Nishida,et al.  Sef is a spatial regulator for Ras/MAP kinase signaling. , 2004, Developmental cell.

[218]  Walter Birchmeier,et al.  The Docking Protein Gab1 Is an Essential Component of an Indirect Mechanism for Fibroblast Growth Factor Stimulation of the Phosphatidylinositol 3-Kinase/Akt Antiapoptotic Pathway , 2004, Molecular and Cellular Biology.

[219]  Liping Xiao,et al.  Stat1 Controls Postnatal Bone Formation by Regulating Fibroblast Growth Factor Signaling in Osteoblasts* , 2004, Journal of Biological Chemistry.

[220]  Ken-ichi Inoue,et al.  Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. , 2004, Genes & development.

[221]  Michael Tsang,et al.  Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway , 2004, Science's STKE.

[222]  S. Murakami,et al.  Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. , 2004, Genes & development.

[223]  E. Laplantine,et al.  Activation of the ERK1/2 and p38 Mitogen-activated Protein Kinase Pathways Mediates Fibroblast Growth Factor-induced Growth Arrest of Chondrocytes* , 2004, Journal of Biological Chemistry.

[224]  D. Goltzman,et al.  Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. , 2003, Human molecular genetics.

[225]  G. McVean,et al.  Evidence for Selective Advantage of Pathogenic FGFR2 Mutations in the Male Germ Line , 2003, Science.

[226]  C. Deng,et al.  A Ser250Trp substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis , 2003 .

[227]  Hiroyuki Tanaka,et al.  Efficacy of growth hormone therapy for patients with skeletal dysplasia , 2003, Journal of Bone and Mineral Metabolism.

[228]  E. Olson,et al.  Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth , 2003, Development.

[229]  D. Rice,et al.  Fgfr mRNA isoforms in craniofacial bone development. , 2003, Bone.

[230]  E. Laplantine,et al.  A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation , 2003, The Journal of cell biology.

[231]  T. Doetschman,et al.  Impaired Osteoclast Formation in Bone Marrow Cultures of Fgf2 Null Mice in Response to Parathyroid Hormone* , 2003, Journal of Biological Chemistry.

[232]  Stephen M Warren,et al.  Age-related Changes in the Biomolecular Mechanisms of Clvarial Osteoblast Biology Affect Fibroblast Growth Factor-2 Signaling and Osteogenesis* , 2003, Journal of Biological Chemistry.

[233]  Zhengliang L. Wu,et al.  The Involvement of Heparan Sulfate (HS) in FGF1/HS/FGFR1 Signaling Complex* , 2003, The Journal of Biological Chemistry.

[234]  M. Longaker,et al.  The BMP antagonist noggin regulates cranial suture fusion , 2003, Nature.

[235]  Wei Wang,et al.  Fibroblast Growth Factors Lead to Increased Msx2 Expression and Fusion in Calvarial Sutures , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[236]  H. Ryoo,et al.  The Protein Kinase C Pathway Plays a Central Role in the Fibroblast Growth Factor-stimulated Expression and Transactivation Activity of Runx2* , 2003, The Journal of Biological Chemistry.

[237]  Marie-Christine Chaboissier,et al.  The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. , 2002, Genes & development.

[238]  E. Nishida,et al.  Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway , 2002, Nature Cell Biology.

[239]  G. Xiao,et al.  Fibroblast Growth Factor 2 Induction of the Osteocalcin Gene Requires MAPK Activity and Phosphorylation of the Osteoblast Transcription Factor, Cbfa1/Runx2* , 2002, The Journal of Biological Chemistry.

[240]  E. Laplantine,et al.  FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest , 2002, The Journal of cell biology.

[241]  M. Pines,et al.  The IIIc alternative of Fgfr2 is a positive regulator of bone formation. , 2002, Development.

[242]  P. Marie,et al.  FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. , 2002, Genes & development.

[243]  I. Lax,et al.  FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[244]  Ola Nilsson,et al.  The role of the resting zone in growth plate chondrogenesis. , 2002, Endocrinology.

[245]  N. Itoh,et al.  FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. , 2002, Genes & development.

[246]  D. Ornitz,et al.  Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. , 2002, Genes & development.

[247]  Kozo Nakamura,et al.  Regulation of Osteoblast, Chondrocyte, and Osteoclast Functions by Fibroblast Growth Factor (FGF)-18 in Comparison with FGF-2 and FGF-10* , 2002, The Journal of Biological Chemistry.

[248]  A. Copp,et al.  Blocking endogenous FGF-2 activity prevents cranial osteogenesis. , 2002, Developmental biology.

[249]  R. Hayward,et al.  From genotype to phenotype: the differential expression of FGF, FGFR, and TGFbeta genes characterizes human cranioskeletal development and reflects clinical presentation in FGFR syndromes. , 2001, Plastic and reconstructive surgery.

[250]  Kozo Nakamura,et al.  Regulation of Osteoclast Differentiation by Fibroblast Growth Factor 2: Stimulation of Receptor Activator of Nuclear Factor κB Ligand/Osteoclast Differentiation Factor Expression in Osteoblasts and Inhibition of Macrophage Colony‐Stimulating Factor Function in Osteoclast Precursors , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[251]  Q. Wang,et al.  Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains. , 2001, Development.

[252]  G. Segre,et al.  Fibroblast Growth Factor Inhibits Chondrocytic Growth through Induction of p21 and Subsequent Inactivation of Cyclin E-Cdk2* , 2001, The Journal of Biological Chemistry.

[253]  M. Mohammadi,et al.  Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[254]  C. Deng,et al.  Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. , 2001, Human molecular genetics.

[255]  J. Lemonnier,et al.  Role of N‐Cadherin and Protein Kinase C in Osteoblast Gene Activation Induced by the S252W Fibroblast Growth Factor Receptor 2 Mutation in Apert Craniosynostosis , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[256]  J. Lemonnier,et al.  Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1. , 2001, The American journal of pathology.

[257]  J. Lemonnier,et al.  Increased Expression of Protein Kinase Cα, Interleukin‐1α, and RhoA Guanosine 5′‐Triphosphatase in Osteoblasts Expressing the Ser252Trp Fibroblast Growth Factor 2 Apert Mutation: Identification by Analysis of Complementary DNA Microarray , 2001 .

[258]  D. Ornitz,et al.  Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[259]  C. Deng,et al.  A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. , 2001, Human molecular genetics.

[260]  G. Waksman,et al.  Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[261]  L A Opperman,et al.  Cranial sutures as intramembranous bone growth sites , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

[262]  S. Rosengren,et al.  Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype. , 2000, American journal of human genetics.

[263]  B. Trueb,et al.  Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. , 2000, Genomics.

[264]  J. Schlessinger Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[265]  Kozo Nakamura,et al.  Fibroblast Growth Factor (FGF)-2 Directly Stimulates Mature Osteoclast Function through Activation of FGF Receptor 1 and p42/p44 MAP Kinase* , 2000, The Journal of Biological Chemistry.

[266]  C. Deng,et al.  A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. , 2000, Human molecular genetics.

[267]  C. Deng,et al.  A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. , 2000, Human molecular genetics.

[268]  C. Basilico,et al.  Signaling by Fibroblast Growth Factors (Fgf) and Fibroblast Growth Factor Receptor 2 (Fgfr2)–Activating Mutations Blocks Mineralization and Induces Apoptosis in Osteoblasts , 2000, The Journal of cell biology.

[269]  D. Rice,et al.  Integration of FGF and TWIST in calvarial bone and suture development. , 2000, Development.

[270]  M. Ito,et al.  Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. , 2000, The Journal of clinical investigation.

[271]  Kozo Nakamura,et al.  Direct and Indirect Actions of Fibroblast Growth Factor 2 on Osteoclastic Bone Resorption in Cultures , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[272]  S. Murakami,et al.  Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[273]  Z. Vajo,et al.  The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. , 2000, Endocrine reviews.

[274]  B. Hall,et al.  All for one and one for all: condensations and the initiation of skeletal development. , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[275]  A. Hasharoni,et al.  Fibroblast growth factor receptor-3 as a marker for precartilaginous stem cells. , 1999, Clinical orthopaedics and related research.

[276]  D. Rice,et al.  Apoptosis in murine calvarial bone and suture development. , 1999, European journal of oral sciences.

[277]  M. Bamshad,et al.  Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. , 1999, American journal of medical genetics.

[278]  D. Levy,et al.  FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. , 1999, Genes & development.

[279]  M. Sabbieti,et al.  Parathyroid Hormone Regulates the Expression of Fibroblast Growth Factor‐2 mRNA and Fibroblast Growth Factor Receptor mRNA in Osteoblastic Cells , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[280]  Richard R. Behringer,et al.  Sox9 is required for cartilage formation , 1999, Nature Genetics.

[281]  D. Givol,et al.  A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[282]  P. Marie,et al.  Differential expression of fibroblast growth factor receptor-1, -2, and -3 and syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro. , 1999, Bone.

[283]  D. Donoghue,et al.  A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene. , 1999, American journal of human genetics.

[284]  P. Marie,et al.  Alterations of matrix- and cell-associated proteoglycans inhibit osteogenesis and growth response to fibroblast growth factor-2 in cultured rat mandibular condyle and calvaria , 1999, Cell and Tissue Research.

[285]  D. Ornitz,et al.  Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. , 1998, Development.

[286]  A. Munnich,et al.  Spatio-temporal expression of FGFR 1, 2 and 3 genes during human embryo-fetal ossification , 1998, Mechanisms of Development.

[287]  A. Munnich,et al.  Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. , 1998, American journal of human genetics.

[288]  W. Wilcox,et al.  Platyspondylic lethal skeletal dysplasia, San Diego type, is caused by FGFR3 mutations. , 1999, American journal of medical genetics.

[289]  J. Buckwalter,et al.  Changes in cell, matrix compartment, and fibrillar collagen volumes between growth‐plate zones , 1998, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[290]  Hiroshi Fukuda,et al.  Recombinant Human Basic Fibroblast Growth Factor Accelerates Fracture Healing by Enhancing Callus Remodeling in Experimental Dog Tibial Fracture , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[291]  M. Muda,et al.  Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. , 1998, Science.

[292]  A. Munnich,et al.  Fibroblast Growth Factor Receptor 3 Mutations Promote Apoptosis but Do Not Alter Chondrocyte Proliferation in Thanatophoric Dysplasia* , 1998, The Journal of Biological Chemistry.

[293]  D. Rice,et al.  FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. , 1998, Development.

[294]  M. Kool,et al.  Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. , 1998, The Journal of clinical investigation.

[295]  P. Marie,et al.  The Effects of Fibroblast Growth Factor‐2 on Human Neonatal Calvaria Osteoblastic Cells Are Differentiation Stage Specific , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[296]  D. Bar-Sagi,et al.  A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway , 1997, Cell.

[297]  Xin-Yuan Fu,et al.  Activation of Statl by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism , 1997, Nature.

[298]  Philip R. Cohen,et al.  FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2. , 1996, The EMBO journal.

[299]  R. Weinberg,et al.  Shared role of the pRB-related p130 and p107 proteins in limb development. , 1996, Genes & development.

[300]  D. Ornitz,et al.  Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia , 1996, Nature Genetics.

[301]  A. Munnich,et al.  Common mutations in the fibroblast growth factor receptor 3 (FGFR 3) gene account for achondroplasia, hypochondroplasia, and thanatophoric dwarfism. , 1996, American journal of medical genetics.

[302]  Gary W. Harding,et al.  Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3 , 1996, Nature Genetics.

[303]  P. Leder,et al.  Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth , 1996, Cell.

[304]  P. Maher,et al.  Distribution of Fibroblast Growth Factor (FGF)-2 and FGF Receptor-1 Messenger RNA Expression and Protein Presence in the Mid-Trimester Human Fetus , 1996, Pediatric Research.

[305]  B. Olwin,et al.  Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[306]  M. Hurley,et al.  Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. , 1995, The Journal of clinical investigation.

[307]  D. Rimoin,et al.  Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3 , 1995, Nature Genetics.

[308]  D. Church,et al.  Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia , 1994, Cell.

[309]  S. Werner,et al.  Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. , 1993, Developmental biology.

[310]  Y. Yarden,et al.  Developmental expression of two murine fibroblast growth factor receptors, flg and bek. , 1991, Development.

[311]  E B Hunziker,et al.  Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats. , 1989, The Journal of physiology.

[312]  B. Kream,et al.  In situ hybridization analysis of the expression of the type II collagen gene in the developing chicken limb bud. , 1988, Collagen and related research.

[313]  K.,et al.  Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth. , 1987, The Journal of bone and joint surgery. American volume.

[314]  D. Gospodarowicz,et al.  Fibroblast growth factor , 1986, Molecular and Cellular Endocrinology.

[315]  W. Kulyk,et al.  Collagen gene expression during limb cartilage differentiation , 1986, The Journal of cell biology.

[316]  P. Krejcí The paradox of FGFR3 signaling in skeletal dysplasia: why chondrocytes growth arrest while other cells over proliferate. , 2014, Mutation research. Reviews in mutation research.

[317]  D. Ornitz,et al.  Development of the endochondral skeleton. , 2013, Cold Spring Harbor perspectives in biology.

[318]  S. Murakami,et al.  FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation , 2011, Journal of Bone and Mineral Metabolism.

[319]  D. Rice,et al.  Locate, condense, differentiate, grow and confront: developmental mechanisms controlling intramembranous bone and suture formation and function. , 2008, Frontiers of oral biology.

[320]  P. Marie,et al.  Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts. , 2008, Frontiers of oral biology.

[321]  M. Hajihosseini Fibroblast growth factor signaling in cranial suture development and pathogenesis. , 2008, Frontiers of oral biology.

[322]  T. Doetschman,et al.  The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling. , 2007, Journal of molecular and cellular cardiology.

[323]  小牧 宏和 Repair of segmental bone defects in rabbit tibiae using a complex of β-tricalcium phosphate, type 1 collagen, and fibroblast growth factor-2 , 2007 .

[324]  A. Moon,et al.  Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes. , 2006, Developmental cell.

[325]  M. Longaker,et al.  Cranial suture biology. , 2005, Current topics in developmental biology.

[326]  O. Fromigué,et al.  Apoptosis in membranous bone formation: role of fibroblast growth factor and bone morphogenetic protein signaling. , 2005, Critical reviews in eukaryotic gene expression.

[327]  K. Nakao,et al.  Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway , 2004, Nature Medicine.

[328]  A. Munnich,et al.  Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias. , 2004, Bone.

[329]  山本 博充 Runx2 and Runx3 are essential for chondrocyte maturation and Runx2 regulates limb growth through induction of Indian hedgehog , 2004 .

[330]  C. Clevenger Signal transduction. , 2003, Breast disease.

[331]  Yukihide Iwamoto,et al.  Effects of FGF-2 on metaphyseal fracture repair in rabbit tibiae , 2003, Journal of Bone and Mineral Metabolism.

[332]  C. Deng,et al.  A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. , 2003, Bone.

[333]  G. Xiao,et al.  Fibroblast Growth Factor 2 Induction of the Osteocalcin Gene Requires MAPK Activity and Phosphorylation of the Osteoblast Transcription Factor , Cbfa 1 / Runx 2 * , 2002 .

[334]  T. Kuroda,et al.  Immunohistochemical localization of fibroblast growth factor receptors in the rat mandibular condylar cartilage and tibial cartilage , 1999, Journal of Bone and Mineral Metabolism.

[335]  J. Massagué TGF-beta signal transduction. , 1998, Annual review of biochemistry.

[336]  A. Munnich,et al.  Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome. , 1998, The Journal of clinical investigation.

[337]  I. Kaitila,et al.  A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia , 1995, Nature Genetics.

[338]  J. Schlessinger,et al.  Signaling by Receptor Tyrosine Kinases , 1993 .

[339]  S. Werner,et al.  Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. , 1992, Development.

[340]  W. Börner,et al.  [Thyroid hormones]. , 1974, Die Medizinische Welt.

[341]  This article cites 117 articles, 43 of which can be accessed free at: , 2022 .