Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.
暂无分享,去创建一个
E. Susaki | H. Ueda | Y. Furukawa | S. Imoto | M. Nakanishi | M. Yanagisawa | K. Matsushima | N. Yoshida | A. Miyajima | S. Yamazaki | H. Ueno | S. Ueha | Satotaka Omori | Teh-Wei Wang | Yoshikazu Johmura | T. Kanai | Y. Nakano | Taketomo Kido | Takuya Nakajima | S. Shichino | M. Ozawa | K. Yokote | Soichiro Kumamoto | A. Nishiyama | T. Sakamoto | K. Yamaguchi | Seira Hatakeyama | Eigo Shimizu | K. Katayama | Yasuhiro Yamada | Kanako Iwasaki | C. Miyoshi | Hiromasa Funato | Takeharu Sakamoto | Hiroo Ueno | Atsuya Nishiyama
[1] D. Sheppard,et al. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung , 2020, bioRxiv.
[2] A. Miyajima,et al. Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction , 2020, Communications Biology.
[3] K. Wagner,et al. Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan. , 2020, Cell metabolism.
[4] Mary C. Regier,et al. A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives , 2020, bioRxiv.
[5] M. Koutsilieris,et al. The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis , 2020, Hepatology.
[6] R. Cardiff,et al. A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion , 2019, Nature Communications.
[7] U. Alon,et al. Senescent cell turnover slows with age providing an explanation for the Gompertz law , 2019, Nature Communications.
[8] S. D’Costa,et al. Controlled induction and targeted elimination of p16INK4a‐expressing chondrocytes in cartilage explant culture , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[9] Y. Saeys,et al. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche , 2019, Immunity.
[10] C. Schmitt,et al. Cellular Senescence: Defining a Path Forward , 2019, Cell.
[11] A. Feldstein,et al. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. , 2019, The Journal of clinical investigation.
[12] Ashley J. Schulte,et al. Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma , 2019, Molecular Cancer Research.
[13] Tomoyuki Mano,et al. Advanced CUBIC tissue clearing for whole-organ cell profiling , 2019, Nature Protocols.
[14] Jiandie D. Lin,et al. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. , 2019, Molecular cell.
[15] P. Fortina,et al. Single-Cell Genomics. , 2019, Clinical chemistry.
[16] S. Bonner-Weir,et al. Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. , 2019, Cell metabolism.
[17] Jiahuai Han,et al. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. , 2019, Journal of hepatology.
[18] A. Ransick,et al. Single Cell Profiling Reveals Sex, Lineage and Regional Diversity in the Mouse Kidney , 2019, bioRxiv.
[19] Angela Oliveira Pisco,et al. A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse , 2019, bioRxiv.
[20] O. Bischof,et al. AP-1 Imprints a Reversible Transcriptional Program of Senescent Cells , 2019, bioRxiv.
[21] J. Bonventre,et al. Cellular Senescence in the Kidney. , 2019, Journal of the American Society of Nephrology : JASN.
[22] Fabian J Theis,et al. PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells , 2019, Genome biology.
[23] J. Parker,et al. Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence , 2019, Proceedings of the National Academy of Sciences.
[24] K. Aird,et al. Jumonji C Demethylases in Cellular Senescence , 2018, Genes.
[25] J. Boeke,et al. LINE-1 derepression in senescent cells triggers interferon and inflammaging , 2018, Nature.
[26] D. Schuppan,et al. The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis , 2018, Nature Reviews Gastroenterology & Hepatology.
[27] K. Sakimura,et al. Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response , 2018, Front. Neurosci..
[28] Haruo Kasai,et al. Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. , 2018, Cell reports.
[29] A. van Oudenaarden,et al. Single-Cell Transcriptomics Meets Lineage Tracing. , 2018, Cell stem cell.
[30] D. Allison,et al. Senolytics Improve Physical Function and Increase Lifespan in Old Age , 2018, Nature Medicine.
[31] James C. Cummings,et al. Profiling of m6A RNA modifications identified an age‐associated regulation of AGO2 mRNA stability , 2018, Aging cell.
[32] Leland McInnes,et al. UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction , 2018, ArXiv.
[33] Fabian J Theis,et al. SCANPY: large-scale single-cell gene expression data analysis , 2018, Genome Biology.
[34] Kohei Miyazono,et al. Whole-Body Profiling of Cancer Metastasis with Single-Cell Resolution. , 2017, Cell reports.
[35] V. Korolchuk,et al. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing , 2017, The Journal of cell biology.
[36] Caroline L. Wilson,et al. Cellular senescence drives age-dependent hepatic steatosis , 2017, Nature Communications.
[37] Shenghui He,et al. Senescence in Health and Disease , 2017, Cell.
[38] S. Picelli. Single-cell RNA-sequencing: The future of genome biology is now , 2017, RNA biology.
[39] Wiggert A. van Cappellen,et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging , 2017, Cell.
[40] E. Laconi,et al. Aging promotes neoplastic disease through effects on the tissue microenvironment , 2016, Aging.
[41] G. Alexander,et al. Senescence in chronic liver disease: Is the future in aging? , 2016, Journal of hepatology.
[42] I. Manabe,et al. Macrophages in age-related chronic inflammatory diseases , 2016, npj Aging and Mechanisms of Disease.
[43] L. Dassa,et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL , 2016, Nature Communications.
[44] M. Serrano,et al. Mitochondrial Damage Induces Senescence with a Twisted Arm. , 2016, Cell metabolism.
[45] A. Pezeshki,et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan , 2016, Nature.
[46] N. Sharpless,et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice , 2015, Nature Medicine.
[47] D. Baker,et al. Cellular senescence in aging and age-related disease: from mechanisms to therapy , 2015, Nature Medicine.
[48] A. Oudenaarden,et al. Design and Analysis of Single-Cell Sequencing Experiments , 2015, Cell.
[49] Clara Correia-Melo,et al. Mitochondria: Are they causal players in cellular senescence? , 2015, Biochimica et biophysica acta.
[50] N. Sharpless,et al. Forging a signature of in vivo senescence , 2015, Nature Reviews Cancer.
[51] C. Abbadie,et al. The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. , 2015, American journal of physiology. Cell physiology.
[52] S. Teichmann,et al. Computational and analytical challenges in single-cell transcriptomics , 2015, Nature Reviews Genetics.
[53] Kumar Sharma,et al. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development , 2014, Nature Medicine.
[54] H. Moch,et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. , 2014, Cancer cell.
[55] M. Nakanishi,et al. Necessary and sufficient role for a mitosis skip in senescence induction. , 2014, Molecular cell.
[56] M. Jacomy,et al. ForceAtlas2, a Continuous Graph Layout Algorithm for Handy Network Visualization Designed for the Gephi Software , 2014, PloS one.
[57] J. Deursen. The role of senescent cells in ageing , 2014, Nature.
[58] E. Susaki,et al. Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis , 2014, Cell.
[59] Masahira Hattori,et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome , 2013, Nature.
[60] T. Shlomi,et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence , 2013, Nature.
[61] Darjus F. Tschaharganeh,et al. Non-Cell-Autonomous Tumor Suppression by p53 , 2013, Cell.
[62] David B. Darr,et al. Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model , 2013, Cell.
[63] P. Rabinovitch,et al. mTOR is a key modulator of ageing and age-related disease , 2013, Nature.
[64] C. Tanaka,et al. An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis , 2013, International journal of experimental pathology.
[65] V. Dulić. Senescence regulation by mTOR. , 2013, Methods in molecular biology.
[66] O. Lesur,et al. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. , 2012, Seminars in immunology.
[67] Hiromitsu Araki,et al. GeneSetDB: A comprehensive meta-database, statistical and visualisation framework for gene set analysis , 2012, FEBS open bio.
[68] E. Pasquier,et al. Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16INK4a during immortalization , 2012, Oncogene.
[69] N. LeBrasseur,et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.
[70] D. Peeper,et al. The essence of senescence. , 2010, Genes & development.
[71] M. Jensen,et al. Fat tissue, aging, and cellular senescence , 2010, Aging cell.
[72] E. Haddad,et al. Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status , 2010, Aging cell.
[73] J. Campisi,et al. The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.
[74] I. Armando,et al. The regulation of proximal tubular salt transport in hypertension: an update , 2009, Current opinion in nephrology and hypertension.
[75] Masayuki Orimo,et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance , 2009, Nature Medicine.
[76] H. Saya,et al. Real-time in vivo imaging of p16Ink4a reveals cross talk with p53 , 2009, The Journal of cell biology.
[77] Matthieu Piel,et al. Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain , 2008, Science.
[78] S. Lowe,et al. Senescence of Activated Stellate Cells Limits Liver Fibrosis , 2008, Cell.
[79] Robert B. Russell,et al. SuperTarget and Matador: resources for exploring drug-target relationships , 2007, Nucleic Acids Res..
[80] J. Campisi,et al. Cellular senescence: when bad things happen to good cells , 2007, Nature Reviews Molecular Cell Biology.
[81] M. Blasco,et al. Cellular Senescence in Cancer and Aging , 2007, Cell.
[82] K. Rajewsky,et al. Excision of the Frt-flanked neoR cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination , 2007, Transgenic Research.
[83] I. Komuro,et al. Vascular Cell Senescence: Contribution to Atherosclerosis , 2007, Circulation research.
[84] I. Weissman,et al. Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands. , 2006, Developmental cell.
[85] M. Bennett,et al. Vascular smooth muscle cell senescence in atherosclerosis. , 2006, Cardiovascular research.
[86] D. Vestweber,et al. Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development , 2006 .
[87] Steffen Jung,et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration , 2005, Nature Methods.
[88] W. Reith,et al. Conditional gene targeting in macrophages and granulocytes using LysMcre mice , 1999, Transgenic Research.
[89] P. Bird,et al. A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock‐in mice , 2003, Genesis.
[90] R. DePinho,et al. p16(INK4a) and p53 deficiency cooperate in tumorigenesis. , 2002, Cancer research.
[91] H. Takano,et al. Senescent cells are resistant to death despite low Bcl-2 level , 2001, Mechanisms of Ageing and Development.
[92] Johannes Gerdes,et al. The Ki‐67 protein: From the known and the unknown , 2000, Journal of cellular physiology.
[93] O. Pereira-smith,et al. Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression , 1996, Science.
[94] F. Zindy,et al. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest , 1995, Cell.
[95] C Roskelley,et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.