Temporary Abolition of Pain in Man

In eight patients with intense chronic cutaneous pain, sensory nerves or roots. supplying the painful area were stimulated. Square-wave 0.1-millisecond pulses at 100 cycles per second were applied, and the voltage was raised until the patient reported tingling in the area. During this stimulation, pressure on previously sensitive areas failed to evoke pain. Four patients, who had diseases of their peripheral nerves, experienced relief of their pain for more than half an hour after stimulation for 2 minutes.

[1]  D. H. Barron,et al.  Intermittent conduction in the spinal cord , 1935, The Journal of physiology.

[2]  P. Wall,et al.  PRESYNAPTIC CONTROL OF IMPULSES AT THE FIRST CENTRAL SYNAPSE IN THE CUTANEOUS PATHWAY. , 1964, Progress in brain research.

[3]  P. Wall The origin of a spinal‐cord slow potential , 1962, Journal of Physiology.

[4]  P. Wall,et al.  Pain mechanisms: a new theory. , 1965, Science.