Circuit-Based Models of Biomolecular System Dynamics

Methods from the field of electrical engineering have been used for the modeling and analysis of biological systems. In this work we exploit parallels between electrical and biological circuits for simulation of biomolecular processes and systems. We review the development of BioXyce, an electrical circuit-based systems biology simulation platform, and demonstrate its use in simulating intracellular biochemical pathways. We present simulation results for metabolic pathways and eukaryotic signal transduction pathways important in host immune response.

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