Prevalence of periodontal disease, its association with systemic diseases and prevention

Periodontal diseases are prevalent both in developed and developing countries and affect about 20-50% of global population. High prevalence of periodontal disease in adolescents, adults, and older individuals makes it a public health concern. Several risk factors such as smoking, poor oral hygiene, diabetes, medication, age, hereditary, and stress are related to periodontal diseases. Robust evidence shows the association of periodontal diseases with systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes. Periodontal disease is likely to cause 19% increase in the risk of cardiovascular disease, and this increase in relative risk reaches to 44% among individuals aged 65 years and over. Type 2 diabetic individuals with severe form of periodontal disease have 3.2 times greater mortality risk compared with individuals with no or mild periodontitis. Periodontal therapy has been shown to improve glycemic control in type 2 diabetic subjects. Periodontitis is related to maternal infection, preterm birth, low birth weight, and preeclampsia. Oral disease prevention strategies should be incorporated in chronic systemic disease preventive initiatives to curtail the burden of disease in populations. The reduction in the incidence and prevalence of periodontal disease can reduce its associated systemic diseases and can also minimize their financial impact on the health-care systems. It is hoped that medical, dental practitioners, and other health-care professionals will get familiar with perio-systemic link and risk factors, and need to refer to the specialized dental or periodontal care.

[1]  P. Petersen,et al.  Strengthening the prevention of periodontal disease: the WHO approach. , 2005, Journal of periodontology.

[2]  C. Charles,et al.  The efficacy of an essential oil antiseptic mouthrinse vs. dental floss in controlling interproximal gingivitis: a comparative study. , 2003, Journal of the American Dental Association.

[3]  Lili Chen,et al.  Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis. , 2011, Internal medicine.

[4]  P. Eke,et al.  Prevalence of Periodontitis in Adults in the United States: 2009 and 2010 , 2012, Journal of dental research.

[5]  M. Leon,et al.  Periodontal disease associates with higher brain amyloid load in normal elderly , 2015, Neurobiology of Aging.

[6]  Regina M. Benjamin,et al.  Oral Health: The Silent Epidemic , 2010, Public health reports.

[7]  J. Vergnes,et al.  Periodontal diseases and cardiovascular events: meta-analysis of observational studies. , 2009, International dental journal.

[8]  R. Niederman Moderate quality evidence finds statistical benefit in oral health for powered over manual toothbrushes , 2014, Evidence-Based Dentistry.

[9]  K. Fenesy Periodontal disease: an overview for physicians. , 1998, The Mount Sinai journal of medicine, New York.

[10]  T. Tözüm,et al.  Effects of endogenous sex hormones on the periodontium--review of literature. , 2005, Australian dental journal.

[11]  D. Winn,et al.  Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss. , 2000, Journal of periodontology.

[12]  M. Newman,et al.  Clinical and antimicrobial effect of stannous fluoride on periodontitis. , 1981, Journal of clinical periodontology.

[13]  Robert L Hanson,et al.  Periodontal disease and mortality in type 2 diabetes. , 2005, Diabetes care.

[14]  G. Burmester,et al.  The association between rheumatoid arthritis and periodontal disease , 2010, Arthritis Research & Therapy.

[15]  Sarah M. Debrey,et al.  Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. , 2007, Journal of periodontology.

[16]  J. Albandar,et al.  Global epidemiology of periodontal diseases: an overview. , 2002, Periodontology 2000.

[17]  Chia-Hung Chiang,et al.  The association of tooth scaling and decreased cardiovascular disease: a nationwide population-based study. , 2012, The American journal of medicine.

[18]  H. Mythri,et al.  The efficacy of antiseptic mouth rinses in comparison with dental floss in controlling interproximal gingivitis , 2011, Journal of International Society of Preventive & Community Dentistry.

[19]  P Deep,et al.  Screening for common oral diseases. , 2000, Journal.

[20]  Howard C. Tenenbaum,et al.  Separating fact from fiction: use of high-level evidence from research syntheses to identify diseases and disorders associated with periodontal disease. , 2012, Journal.

[21]  M. Elkind,et al.  Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III , 2009, Journal of Neurology, Neurosurgery & Psychiatry.

[22]  E. Bouřa,et al.  The influence of sex hormones on proinflammatory cytokines in gingiva of periodontally healthy premenopausal women. , 2011, Journal of periodontal research.

[23]  J. Gunsolley A meta-analysis of six-month studies of antiplaque and antigingivitis agents. , 2006, Journal of the American Dental Association.

[24]  V. E. Atabay,et al.  Obesity and oxidative stress in patients with different periodontal status: a case–control study , 2017, Journal of periodontal research.

[25]  I. Maes,et al.  [Effects of smoking on periodontal disease]. , 2009, Revue des maladies respiratoires.

[26]  A. Spiro,et al.  Tooth Loss and Periodontal Disease Predict Poor Cognitive Function in Older Men , 2010, Journal of the American Geriatrics Society.

[27]  Sang Gyu Lim,et al.  Association between insulin resistance and periodontitis in Korean adults. , 2014, Journal of clinical periodontology.

[28]  S. Fitzpatrick,et al.  The association between periodontal disease and cancer: a review of the literature. , 2010, Journal of dentistry.

[29]  G. Taylor,et al.  A prediction model for chronic kidney disease includes periodontal disease. , 2009, Journal of periodontology.

[30]  J. Gunsolley,et al.  Clinical efficacy of antimicrobial mouthrinses. , 2010, Journal of dentistry.

[31]  S. Barros,et al.  Histometric evaluation of the effect of nicotine administration on periodontal breakdown: an in vivo study. , 2001, Journal of periodontal research.

[32]  M. Laine Effect of pregnancy on periodontal and dental health , 2002, Acta odontologica Scandinavica.

[33]  J. Jones,et al.  Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. , 2003, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[34]  M. R. Guglielmetti,et al.  Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. , 2013, Journal of clinical periodontology.

[35]  Benjamin W Chaffee,et al.  Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. , 2010, Journal of periodontology.

[36]  J. Radford Is weight gain associated with the incidence of periodontitis? A systematic review and meta-analysis , 2015, BDJ.

[37]  J. M. A. Silla,et al.  Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature. , 2008 .

[38]  Abhijit N Gurav Periodontitis and Insulin Resistance: Casual or Causal Relationship? , 2012, Diabetes & metabolism journal.

[39]  D. Kinane,et al.  Periodontal manifestations of systemic disease. , 2001, Australian dental journal.

[40]  P. Papapanou,et al.  Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes--systematic review. , 2013, Journal of clinical periodontology.

[41]  J. Bergstrom Smoking rate and periodontal disease prevalence: 40-year trends in Sweden 1970-2010. , 2014, Journal of clinical periodontology.

[42]  S. Segerstrom,et al.  Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. , 2004, Psychological bulletin.

[43]  O. Erel,et al.  Oxidative Stress and Periodontal Disease in Obesity , 2016, Medicine.

[44]  J. A. McGuire,et al.  Adjunctive benefit of an essential oil-containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. , 2004, Journal of the American Dental Association.

[45]  P. Axelsson Current role of pharmaceuticals in prevention of caries and periodontal disease. , 1993, International dental journal.

[46]  P. Preshaw,et al.  Diabetes and periodontal disease: a two-way relationship , 2014, BDJ.

[47]  Thomas Dietrich,et al.  Periodontitis in systemic rheumatic diseases , 2009, Nature Reviews Rheumatology.

[48]  J. Ryu,et al.  Risk assessment for clinical attachment loss of periodontal tissue in Korean adults , 2011, The journal of advanced prosthodontics.

[49]  R. Jacobs,et al.  Salivary stress markers, stress, and periodontitis: a pilot study. , 2011, Journal of periodontology.

[50]  A. Vissink,et al.  Periodontal disease and decreased kidney function in Japanese elderly. , 2012, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[51]  M. Brecx,et al.  Stress and periodontal disease. , 2007, International journal of dental hygiene.

[52]  J S Brown,et al.  Oral biofilms, periodontitis and pulmonary infections. , 2007, Oral diseases.

[53]  R. Genco,et al.  Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. , 2013, Journal of periodontology.

[54]  E. Ioannidou,et al.  Periodontitis associated with chronic kidney disease among Mexican Americans. , 2013, Journal of public health dentistry.

[55]  G. Casazza,et al.  Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials. , 2009, American journal of obstetrics and gynecology.

[56]  M. Trevisan,et al.  Dietary vitamin C and the risk for periodontal disease. , 2000, Journal of periodontology.

[57]  Paula J Moynihan,et al.  The role of diet and nutrition in the etiology and prevention of oral diseases. , 2005, Bulletin of the World Health Organization.

[58]  Rongwei Fu,et al.  Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis , 2008, Journal of General Internal Medicine.

[59]  S. Barros,et al.  Exploring the relationship between periodontal disease and pregnancy complications. , 2006, Journal of the American Dental Association.

[60]  J. Wactawski‐Wende,et al.  Chronic periodontitis and the risk of tongue cancer. , 2007, Archives of otolaryngology--head & neck surgery.

[61]  H. Hwang,et al.  Associations Between Periodontitis and Chronic Obstructive Pulmonary Disease: The 2010 to 2012 Korean National Health and Nutrition Examination Survey. , 2016, Journal of periodontology.

[62]  G. Koch,et al.  Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. , 1994, Journal of periodontology.

[63]  N. Donos,et al.  Chlorhexidine Substantivity on Salivary Flora and Plaque-Like Biofilm: An In Situ Model , 2013, PloS one.

[64]  J. Kreth,et al.  Influence of a model human defensive peroxidase system on oral streptococcal antagonism. , 2009, Microbiology.

[65]  Bruno G. Loos,et al.  Effect of Periodontal Treatment on Glycemic Control of Diabetic Patients , 2010, Diabetes Care.

[66]  G. K. Johnson,et al.  Cigarette smoking and the periodontal patient. , 2004, Journal of periodontology.

[67]  P. Preshaw,et al.  Periodontitis: oral complication of diabetes. , 2013, Endocrinology and metabolism clinics of North America.

[68]  E. Giovannucci,et al.  Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. , 2008, The Lancet. Oncology.

[69]  S. Jamelli,et al.  Maternal periodontitis as a risk factor for prematurity , 2012, Pediatrics international : official journal of the Japan Pediatric Society.

[70]  W. Grant Disparities in Periodontitis Prevalence among Chronic Kidney Disease Patients , 2012, Journal of dental research.

[71]  F. Hughes,et al.  The prevalence of periodontal disease in a Romano-British population c. 200-400 AD , 2014, BDJ.

[72]  F. Fernández‐Avilés,et al.  European workshop in periodontal health and cardiovascular disease—scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature , 2010 .

[73]  M. Moss,et al.  Diabetes and tooth loss: an analysis of data from the National Health and Nutrition Examination Survey, 2003-2004. , 2013, Journal of the American Dental Association.

[74]  E. L. Mortensen,et al.  Periodontal inflammation in relation to cognitive function in an older adult Danish population. , 2012, Journal of Alzheimer's disease : JAD.

[75]  D. Locker,et al.  Epidemiology of periodontal disease among older adults: a review. , 1998, Periodontology 2000.

[76]  S. Tomar,et al.  Smoking-attributable periodontitis in the United States: findings from NHANES III. National Health and Nutrition Examination Survey. , 2000, Journal of periodontology.

[77]  W. Borgnakke,et al.  Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. , 2013, Journal of periodontology.

[78]  P Axelsson,et al.  On the prevention of caries and periodontal disease. Results of a 15-year longitudinal study in adults. , 1991, Journal of clinical periodontology.

[79]  Mark Hamer,et al.  Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey , 2010, BDJ.

[80]  Chia-Hung Chen,et al.  Risk of Periodontal Diseases in Patients With Chronic Obstructive Pulmonary Disease , 2015, Medicine.

[81]  M. Barker,et al.  Anti-gingivitis effects of a novel 0.454% stabilized stannous fluoride dentifrice relative to a positive control. , 2012, American journal of dentistry.

[82]  J. Lash,et al.  Periodontal disease, chronic kidney disease and mortality: results from the third national health and nutrition examination survey , 2015, BMC Nephrology.

[83]  C. Scully,et al.  Drug effects on salivary glands: dry mouth. , 2003, Oral diseases.

[84]  P. Bartold,et al.  Inter-relationships between rheumatoid arthritis and periodontal disease. A review. , 2003, Journal of clinical periodontology.

[85]  B. Heitmann,et al.  The Association Between Periodontal Disease and Overweight and Obesity : A Systematic Review , 2015 .

[86]  J. Strauss,et al.  Cognitive impairment in older adults and oral health considerations: treatment and management. , 2014, Dental clinics of North America.

[87]  P. Hodge,et al.  Smoking cessation and periodontal health – a missed opportunity? , 2009, Evidence-Based Dentistry.

[88]  J. Albandar Global risk factors and risk indicators for periodontal diseases. , 2002, Periodontology 2000.

[89]  G. Colditz,et al.  Post-menopausal hormone use and tooth loss: a prospective study. , 1996, Journal of the American Dental Association.