Complications of 90 Y Radioembolization Treatment for Liver Tumors

Abstract Y90 radioembolization has been demonstrated to be a safe and effective treatment for patients with HCC and for certain liver metastases, such as neuroendocrine tumors, uveal melanomas, and breast cancer. Although the procedure is relatively safe, the complications associated with radioembolization vary greatly in their locations, presentation, and severity. This review aims to discuss and increase awareness of the potential complications associated with radioembolization.

[1]  G. Johnson,et al.  Advances in Y-90 radioembolization for the treatment of hepatocellular carcinoma , 2022, Hepatoma Research.

[2]  G. Johnson,et al.  Recognizing and Managing Adverse Events in Y-90 Radioembolization , 2021, Seminars in Interventional Radiology.

[3]  H. Amthauer,et al.  Impact of Pharmaceutical Prophylaxis on Radiation-Induced Liver Disease Following Radioembolization , 2021, Cancers.

[4]  R. Salem,et al.  Yttrium‐90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study , 2021, Hepatology.

[5]  T. Baker,et al.  Safety and efficacy of repeat Y90 radioembolization to the same hepatic arterial territory. , 2021, The British journal of radiology.

[6]  J. Zucman‐Rossi,et al.  Hepatocellular carcinoma , 1998, Nature Reviews Disease Primers.

[7]  Selin Kesim,et al.  Unexpected radiation pneumonitis after SIRT with significant decrease in DLCO with internal radiation exposure: a case report , 2020, BMC Medical Imaging.

[8]  M. Feretis,et al.  Yttrium-90 radioembolization for unresectable hepatic metastases of breast cancer: A systematic review , 2020, World journal of gastrointestinal oncology.

[9]  W. Pabon-Ramos,et al.  Recognition and management of dermatologic complications from interventional radiology procedures. , 2019, Diagnostic and interventional imaging.

[10]  A. Villanueva.  Hepatocellular Carcinoma. , 2019, The New England journal of medicine.

[11]  S. Alzubaidi,et al.  History and Evolution of Yttrium-90 Radioembolization for Hepatocellular Carcinoma , 2019, Journal of clinical medicine.

[12]  O. M. Topçuoğlu,et al.  Safety of transarterial radioembolization with Yttrium-90 glass microspheres without cystic artery occlusion , 2019, La radiologia medica.

[13]  A. Berman,et al.  Radiation Pneumonitis: Old Problem, New Tricks , 2018, Cancers.

[14]  M. Abecassis,et al.  Radiation Segmentectomy: Potential Curative Therapy for Early Hepatocellular Carcinoma. , 2018, Radiology.

[15]  Weiping Wang,et al.  Yttrium-90 radioembolization for unresectable metastatic neuroendocrine liver tumor: A systematic review. , 2018, European journal of radiology.

[16]  R. Salem,et al.  90Y Radioembolization for Locally Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Long-Term Outcomes in a 185-Patient Cohort , 2017, The Journal of Nuclear Medicine.

[17]  B. Sangro,et al.  Prevention and treatment of complications of selective internal radiation therapy: Expert guidance and systematic review , 2017, Hepatology.

[18]  R. Salem,et al.  Erratum: Hepatic Radioembolization Complicated by Abscess. , 2017, Seminars in interventional radiology.

[19]  M. A. van den Bosch,et al.  Radioembolization-induced liver disease: a systematic review , 2017, European journal of gastroenterology & hepatology.

[20]  William H. Bisson,et al.  Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions , 2017, Cellular and molecular gastroenterology and hepatology.

[21]  Thomas G. Walker,et al.  Radioembolization of Hepatic Malignancies: Background, Quality Improvement Guidelines, and Future Directions. , 2017, Journal of vascular and interventional radiology : JVIR.

[22]  R. Decker,et al.  Radiation Pneumonitis. , 2017, Clinics in chest medicine.

[23]  S. Gananadha,et al.  Cholecystitis after yttrium-90 resin microsphere radioembolization treatment: Clinical and pathologic findings. , 2016, Asian journal of surgery.

[24]  Jun Li,et al.  Yttrium-90 Microsphere Brachytherapy for Liver Metastases From Uveal Melanoma: Clinical Outcomes and the Predictive Value of Fluorodeoxyglucose Positron Emission Tomography , 2016, American journal of clinical oncology.

[25]  R. Madan,et al.  Radiation induced liver disease: A clinical update. , 2016, Journal of the Egyptian National Cancer Institute.

[26]  R. Gaba.  Planning Arteriography for Yttrium-90 Microsphere Radioembolization , 2015, Seminars in Interventional Radiology.

[27]  F. Fischbach,et al.  Prophylactic Embolization of the Cystic Artery Prior to Radioembolization of Liver Malignancies—An Evaluation of Necessity , 2015, Cardiovascular and Interventional Radiology.

[28]  R. Salem,et al.  Side Effects of Yttrium-90 Radioembolization , 2014, Front. Oncol..

[29]  S. Kalva,et al.  Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer , 2014, Front. Oncol..

[30]  Jasmin A. Tiro,et al.  Therapeutic delays lead to worse survival among patients with hepatocellular carcinoma. , 2013, Journal of the National Comprehensive Cancer Network : JNCCN.

[31]  D. Sze,et al.  Prophylactic topically applied ice to prevent cutaneous complications of nontarget chemoembolization and radioembolization. , 2013, Journal of vascular and interventional radiology : JVIR.

[32]  N. Veloso,et al.  Gastroduodenal ulceration following liver radioembolization with yttrium-90 , 2013, Endoscopy.

[33]  R. Salem,et al.  Radiation pneumonitis following yttrium-90 radioembolization: case report and literature review. , 2012, Journal of vascular and interventional radiology : JVIR.

[34]  N. Pavlakis,et al.  Radioembolization versus standard care of hepatic metastases: comparative retrospective cohort study of survival outcomes and adverse events in salvage patients. , 2012, Journal of vascular and interventional radiology : JVIR.

[35]  R. Hickey,et al.  Hepatic radioembolization complicated by radiation cholecystitis. , 2011, Seminars in interventional radiology.

[36]  J. Machac,et al.  Gastroduodenal Ulceration Associated with Radioembolization for the Treatment of Hepatic Tumors: An Institutional Experience and Review of the Literature , 2010, Digestive Diseases and Sciences.

[37]  M. Mulcahy,et al.  Hepatic Abscess After Yttrium-90 Radioembolization for Islet-Cell Tumor Hepatic Metastasis , 2010, CardioVascular and Interventional Radiology.

[38]  M. Mulcahy,et al.  Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature review. , 2009, Journal of vascular and interventional radiology : JVIR.

[39]  P. Chow,et al.  Radiation dermatitis following radioembolization for hepatocellular carcinoma: a case for prophylactic embolization of a patent falciform artery. , 2009, Journal of vascular and interventional radiology : JVIR.

[40]  M. Mulcahy,et al.  Incidence of Radiation Pneumonitis After Hepatic Intra-Arterial Radiotherapy With Yttrium-90 Microspheres Assuming Uniform Lung Distribution , 2008, American journal of clinical oncology.

[41]  B. Sangro,et al.  Liver disease induced by radioembolization of liver tumors , 2008, Cancer.

[42]  N. Petrelli,et al.  The Toxicity of Liver Directed Yttrium-90 Microspheres in Primary and Metastatic Liver Tumors , 2008, Cancer investigation.

[43]  M. Mulcahy,et al.  Radiation dose limits and liver toxicities resulting from multiple yttrium-90 radioembolization treatments for hepatocellular carcinoma. , 2007, Journal of vascular and interventional radiology : JVIR.

[44]  R. Murthy,et al.  Gastrointestinal complications associated with hepatic arterial Yttrium-90 microsphere therapy. , 2007, Journal of vascular and interventional radiology : JVIR.

[45]  B. Sangro,et al.  Gastroduodenal Injury After Radioembolization of Hepatic Tumors , 2007, The American Journal of Gastroenterology.

[46]  O. Matsui,et al.  Extrahepatic Blood Supply to Hepatocellular Carcinoma: Angiographic Demonstration and Transcatheter Arterial Chemoembolization , 2006, CardioVascular and Interventional Radiology.

[47]  W. Lau,et al.  Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. , 1995, International journal of radiation oncology, biology, physics.