For an actual visible light communication system, it is necessary to consider the uniformity of indoor illumination. Most of the existing optimization schemes, however, do not consider the effect of the first reflected light, and do not conform to the practical application conventions, which increases the actual cost and the complexity of system construction. In this paper, considering the first reflected light and based on the conventional layout model and the classic indoor visible light communication model, a scheme using the parameter Q to determine the optimal layout of channel quality is proposed. We determined the layout, and then carried out a simulation. For comparison, the normal layout and the optimal layout of illumination were also simulated. The simulation results show that the illuminance distributions of the three layouts meet the standards of the International Organization for Standardization. The optimal layout of channel quality in the signal-to-noise ratio distribution, maximum delay spread distribution, and impulse response is obviously better than the optimal layout of illumination. In particular, the effective area percentage of the optimal layout of channel quality is increased by 0.32% and 6.08% to 88.80% as compared with the normal layout’s 88.48% and the optimal layout of illumination’s 82.72%. However, compared with the normal layout, the advantages are not very prominent.