Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect.

[1]  S. Cramer.  Marrow-Derived Mesenchymal Stromal Cells in the Treatment of Stroke , 2016 .

[2]  Y. Tabata,et al.  Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel. , 2014, Biomaterials.

[3]  Jiang Chang,et al.  Silicate bioceramics enhanced vascularization and osteogenesis through stimulating interactions between endothelia cells and bone marrow stromal cells. , 2014, Biomaterials.

[4]  J. Werkmeister,et al.  Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles. , 2014, Biomaterials.

[5]  Changsheng Liu,et al.  Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2. , 2014, Biomaterials.

[6]  Shaobing Zhou,et al.  Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid , 2014, Pharmaceutical Research.

[7]  Shaobing Zhou,et al.  Synergistic effect of released dexamethasone and surface nanoroughness on mesenchymal stem cell differentiation. , 2013, Biomaterials science.

[8]  W. Cui,et al.  Tendon healing and anti-adhesion properties of electrospun fibrous membranes containing bFGF loaded nanoparticles. , 2013, Biomaterials.

[9]  B. Ding,et al.  Biomimetic electrospun nanofibrous structures for tissue engineering. , 2013, Materials today.

[10]  Ralph Müller,et al.  Low dose BMP-2 treatment for bone repair using a PEGylated fibrinogen hydrogel matrix. , 2013, Biomaterials.

[11]  W. Tan,et al.  Effect of porosity on long-term degradation of poly (ε-caprolactone) scaffolds and their cellular response , 2013 .

[12]  Wenxin Wang,et al.  Encapsulation and 3D culture of human adipose-derived stem cells in an in-situ crosslinked hybrid hydrogel composed of PEG-based hyperbranched copolymer and hyaluronic acid , 2013, Stem Cell Research & Therapy.

[13]  Georg N Duda,et al.  Biomaterial delivery of morphogens to mimic the natural healing cascade in bone. , 2012, Advanced drug delivery reviews.

[14]  Shaobing Zhou,et al.  Modulating cellular behaviors through surface nanoroughness , 2012 .

[15]  Chaoyang Wang,et al.  Chitosan nanoparticles as particular emulsifier for preparation of novel pH-responsive Pickering emulsions and PLGA microcapsules , 2012 .

[16]  S. Ramakrishna,et al.  Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering. , 2012, Acta biomaterialia.

[17]  Ahmed O Elzoghby,et al.  Albumin-based nanoparticles as potential controlled release drug delivery systems. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[18]  C. Deng,et al.  TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation , 2012, International journal of biological sciences.

[19]  Cato T Laurencin,et al.  Bone tissue engineering: recent advances and challenges. , 2012, Critical reviews in biomedical engineering.

[20]  S. Tangl,et al.  The effect of BMP-2 on the osteoconductive properties of β-tricalcium phosphate in rat calvaria defects. , 2011, Biomaterials.

[21]  Shaobing Zhou,et al.  Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. , 2011, Biomaterials.

[22]  Eyal Zussman,et al.  Slow-release human recombinant bone morphogenetic protein-2 embedded within electrospun scaffolds for regeneration of bone defect: in vitro and in vivo evaluation. , 2011, Tissue engineering. Part A.

[23]  Yan Sun,et al.  Bioactive Electrospun Scaffolds Delivering Growth Factors and Genes for Tissue Engineering Applications , 2010, Pharmaceutical Research.

[24]  Nuno M Neves,et al.  Osteogenic induction of hBMSCs by electrospun scaffolds with dexamethasone release functionality. , 2010, Biomaterials.

[25]  Franz Jakob,et al.  Autocrine fibroblast growth factor 18 mediates dexamethasone‐induced osteogenic differentiation of murine mesenchymal stem cells , 2010, Journal of cellular physiology.

[26]  K. Popat,et al.  Bone tissue engineering: A review in bone biomimetics and drug delivery strategies , 2009, Biotechnology progress.

[27]  Hae-Won Kim,et al.  Electrospun materials as potential platforms for bone tissue engineering. , 2009, Advanced drug delivery reviews.

[28]  H. Uludaǧ,et al.  Pharmacokinetics and bone formation by BMP-2 entrapped in polyethylenimine-coated albumin nanoparticles. , 2009, Biomaterials.

[29]  A. Lendlein,et al.  Knowledge‐Based Approach towards Hydrolytic Degradation of Polymer‐Based Biomaterials , 2009, Advanced materials.

[30]  Michael J Yaszemski,et al.  Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. , 2009, Biomaterials.

[31]  J. Fischer,et al.  Dexamethasone modulates BMP‐2 effects on mesenchymal stem cells in vitro , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[32]  W. Lu,et al.  Development and evaluation of novel itraconazole-loaded intravenous nanoparticles. , 2008, International journal of pharmaceutics.

[33]  R. Zernicke,et al.  Preparation of BMP-2 Containing Bovine Serum Albumin (BSA) Nanoparticles Stabilized by Polymer Coating , 2008, Pharmaceutical Research.

[34]  D. Bikiaris,et al.  Chitosan nanoparticles loaded with dorzolamide and pramipexole , 2008 .

[35]  R. Lenkinski,et al.  Choline Autoradiography of Human Prostate Cancer Xenograft: Effect of Castration , 2008, Molecular Imaging.

[36]  R. Lenkinski,et al.  Humoral Bone Morphogenetic Protein 2 Is Sufficient for Inducing Breast Cancer Microcalcification , 2008, Molecular imaging.

[37]  H. Jennissen,et al.  Polyethylenimine‐coated albumin nanoparticles for BMP‐2 delivery , 2008, Biotechnology progress.

[38]  Koichi Matsuo,et al.  Osteoclast-osteoblast communication. , 2008, Archives of biochemistry and biophysics.

[39]  Molly M. Stevens,et al.  Biomaterials for bone tissue engineering , 2008 .

[40]  K. Omura,et al.  Effects of continuous dexamethasone treatment on differentiation capabilities of bone marrow-derived mesenchymal cells. , 2007, Bone.

[41]  O. Barbier,et al.  Bone allografts: What they can offer and what they cannot. , 2007, The Journal of bone and joint surgery. British volume.

[42]  S. Mann,et al.  An ex vivo model for chondrogenesis and osteogenesis. , 2007, Biomaterials.

[43]  E. Langenfeld,et al.  Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5 , 2006, Oncogene.

[44]  Julian R Jones,et al.  Hierarchical porous materials for tissue engineering , 2006, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[45]  Y. Tabata,et al.  Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate. , 2005, Biomaterials.

[46]  C. Remuñán-López,et al.  Microencapsulated chitosan nanoparticles for lung protein delivery. , 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[47]  S. Hollister.  Porous scaffold design for tissue engineering , 2005, Nature materials.

[48]  R. Bizios,et al.  Engineering bone: challenges and obstacles , 2005, Journal of cellular and molecular medicine.

[49]  Yasuhiko Tabata,et al.  Collagenous matrices as release carriers of exogenous growth factors. , 2004, Biomaterials.

[50]  Hwal Suh,et al.  Sustained release of ascorbate-2-phosphate and dexamethasone from porous PLGA scaffolds for bone tissue engineering using mesenchymal stem cells. , 2003, Biomaterials.

[51]  Roland Baron,et al.  BMP‐2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[52]  Hua Yang,et al.  Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. , 2003, Biomaterials.

[53]  T. Park,et al.  Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. , 2003, Biomaterials.

[54]  Patrick Soon-Shiong,et al.  Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[55]  L G Griffith,et al.  Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. , 2001, Tissue engineering.

[56]  A. Skoultchi,et al.  Coordinating cell proliferation and differentiation. , 2001, Current opinion in genetics & development.

[57]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[58]  K. Burg,et al.  Biomaterial developments for bone tissue engineering. , 2000, Biomaterials.

[59]  M. Kumegawa,et al.  Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts. , 2000, Bone.

[60]  A. Meunier,et al.  Tissue-engineered bone regeneration , 2000, Nature Biotechnology.

[61]  E. Burger,et al.  Bone morphogenetic proteins in human bone regeneration. , 2000, European journal of endocrinology.

[62]  Kohei Miyazono,et al.  TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.

[63]  K. Chihara,et al.  Dexamethasone Stimulates Osteoclast‐like Cell Formation by Directly Acting on Hemopoietic Blast Cells and Enhances Osteoclast‐like Cell Formation Stimulated by Parathyroid Hormone and Prostaglandin E2 , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[64]  S. Bruder,et al.  Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro , 1997, Journal of cellular biochemistry.

[65]  F. Piquard,et al.  Safety and efficacy of a new transpulmonary echo contrast agent in echocardiographic studies in patients. , 1993, Journal of the American College of Cardiology.

[66]  P. Speiser,et al.  Nanoparticles--a new colloidal drug delivery system. , 1978, Pharmaceutica acta Helvetiae.