LINDSAY Virtual Human: Multi-scale, Agent-based, and Interactive

We are developing LINDSAY Virtual Human, a 3-dimensional, interactive computer model of male and female anatomy and physiology. LINDSAY is designed to be used for medical education. One key characteristic of LINDSAY is the integration of computational models across a range of spatial and temporal scales. We simulate physiological processes in an integrative fashion: from the body level to the level of organs, tissues, cells, and sub-cellular structures. For use in the classroom, we have built LINDSAY Presenter, a 3D slide-based visualization and exploration environment that presents different scenarios within the simulated human body. We are developing LINDSAY Composer to create complex scenes for demonstration, exploration and investigation of physiological scenarios. At LINDSAY Composer′s core is a graphical programming environment, which facilitates the composition of complex, interactive educational modules around the human body.

[1]  Sam Malek,et al.  Improving Availability in Large, Distributed Component-Based Systems Via Redeployment , 2005, Component Deployment.

[2]  Murali Sitaraman,et al.  Foundations of component-based systems , 2000 .

[3]  Christian Jacob,et al.  Biomolecular swarms – an agent-based model of the lactose operon , 2004, Natural Computing.

[4]  C. Sensen,et al.  Advanced Imaging in Biology and Medicine , 2009 .

[5]  Christian Jacob,et al.  Swarms and Genes: Exploring λ - Switch Gene Regulation through Swarm Intelligence , 2006, 2006 IEEE International Conference on Evolutionary Computation.

[6]  Mary Shaw,et al.  Component-based software engineering and the issue of trust , 2000, Proceedings of the 2000 International Conference on Software Engineering. ICSE 2000 the New Millennium.

[7]  Guy Theraulaz,et al.  Self-Organization in Biological Systems , 2001, Princeton studies in complexity.

[8]  P. Hunter,et al.  Integration from proteins to organs: the Physiome Project , 2003, Nature Reviews Molecular Cell Biology.

[9]  Takuro Tamura,et al.  BodyParts3D: 3D structure database for anatomical concepts , 2008, Nucleic Acids Res..

[10]  Robert H. Anderson,et al.  Visible Human Projects Special Issue , 2006, Clinical anatomy.

[11]  Marco Dorigo,et al.  Swarm intelligence: from natural to artificial systems , 1999 .

[12]  I. Yazdanbod,et al.  An Agent-Based Simulation of Blood Coagulation Processes , 2011 .

[13]  Michael J. Ackerman,et al.  From Data to Knowledge - the Visible Human Project® Continues , 2001, MedInfo.

[14]  Steven Johnson,et al.  Emergence: The Connected Lives of Ants, Brains, Cities, and Software , 2001 .

[15]  Dawn C. Walker,et al.  The virtual cellça candidate co-ordinator for ‘middle-out’ modelling of biological systems , 2009 .

[16]  Mike Holcombe,et al.  Formal agent-based modelling of intracellular chemical interactions. , 2006, Bio Systems.

[17]  COMPONENT-BASED SOFTWARE PRODUCT LINE ENGINEERING , 2013 .

[18]  Eyal de Lara,et al.  Puppeteer: component-based adaptation for mobile computing , 2000, OPSR.

[19]  George N. Reeke,et al.  BOOK REVIEW: "SELF-ORGANIZATION IN BIOLOGICAL SYSTEMS" BY S. CAMAZINE, J. DENEUBOURG, N. R. FRANKS, J. SNEYD, G. THERAULAZ AND E. BONABEAU , 2002 .

[20]  Daniel A. Tietze.  A framework for developing component based cooperative applications , 2001 .

[21]  Bernd Brügge,et al.  Design of a component-based augmented reality framework , 2001, Proceedings IEEE and ACM International Symposium on Augmented Reality.

[22]  Scott M. Lewandowski,et al.  Frameworks for component-based client/server computing , 1998, CSUR.

[23]  Christian Jacob,et al.  Transcription and evolution of a virtual bacteria culture , 2003, The 2003 Congress on Evolutionary Computation, 2003. CEC '03..

[24]  Timothy Davison,et al.  Component-based networking for simulations in medical education , 2010, The IEEE symposium on Computers and Communications.

[26]  Stephen Wolfram,et al.  A New Kind of Science , 2003, Artificial Life.

[27]  Frédéric Guidec,et al.  Cooperative Component-Based Software Deployment in Wireless Ad Hoc Networks , 2005, Component Deployment.

[28]  M. F. Seifert,et al.  Special issue on Visible Human Projects , 2006 .

[29]  Christoph Wilhelm Sensen,et al.  CAVEman, An Object-Oriented Model of the Human Body , 2009 .

[30]  Karl-Erik Årzén,et al.  A Component-Based Approach to the Design of Networked Control Systems , 2007, Eur. J. Control.